STRINGSTRING
TP53BP1 TP53BP1 RAD50 RAD50 SLF1 SLF1 LOC105713780 LOC105713780 BRCA1 BRCA1 MRE11 MRE11 HELB HELB EXO1 EXO1 RPA3 RPA3 RBBP8 RBBP8 MCPH1 MCPH1 CHEK2 CHEK2 RAD1 RAD1 RPA1 RPA1 ATM ATM HUS1 HUS1 RAD9B RAD9B RAD52 RAD52 EXD2 EXD2 TOP3A TOP3A RECQL4 RECQL4 RFWD3 RFWD3 LOC105717573 LOC105717573 FANCM FANCM ATR ATR BRCA2 BRCA2 BRIP1 BRIP1 RAD51D RAD51D RAD9A RAD9A PIF1 PIF1 RECQL5 RECQL5 ENSANAP00000017921 ENSANAP00000017921 BARD1 BARD1 LOC105731879 LOC105731879 RAD51C RAD51C RAD17 RAD17 ENSANAP00000020274 ENSANAP00000020274 XRCC2 XRCC2 XRCC3 XRCC3 ZRANB3 ZRANB3 ANKRD12 ANKRD12 ATRIP ATRIP RPA4 RPA4 TOPBP1 TOPBP1 TDRD3 TDRD3 RMI2 RMI2 DMC1 DMC1 TOP3B TOP3B FBH1 FBH1 WRN WRN MEIOB MEIOB ENSANAP00000034595 ENSANAP00000034595 SMARCAL1 SMARCAL1 NBN NBN RHNO1 RHNO1 ENSANAP00000039680 ENSANAP00000039680 CLSPN CLSPN ENSANAP00000040885 ENSANAP00000040885 RAD51B RAD51B RAD51 RAD51 BLM BLM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53BP1Tumor protein p53 binding protein 1. (1971 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1039 aa)
LOC105713780RPA_C domain-containing protein. (274 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1827 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (642 aa)
HELBDNA helicase B. (1184 aa)
EXO1Exonuclease 1. (848 aa)
RPA3Replication protein A3. (134 aa)
RBBP8Uncharacterized protein. (898 aa)
MCPH1Microcephalin 1. (858 aa)
CHEK2Checkpoint kinase 2. (589 aa)
RAD1RAD1 checkpoint DNA exonuclease. (242 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (415 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
RECQL4RecQ like helicase 4. (1208 aa)
RFWD3Ring finger and WD repeat domain 3. (771 aa)
LOC105717573Uncharacterized protein. (319 aa)
FANCMFA complementation group M. (2047 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2642 aa)
BRCA2BRCA2 DNA repair associated. (3404 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1252 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (327 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (412 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (678 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa)
ENSANAP00000017921RPA_C domain-containing protein. (232 aa)
BARD1BRCA1 associated RING domain 1. (769 aa)
LOC105731879RPA_C domain-containing protein. (256 aa)
RAD51CRAD51 paralog C. (367 aa)
RAD17RAD17 checkpoint clamp loader component. (705 aa)
ENSANAP00000020274Uncharacterized protein. (552 aa)
XRCC2X-ray repair cross complementing 2. (295 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (398 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1120 aa)
ANKRD12Ankyrin repeat domain 12. (2057 aa)
ATRIPATR interacting protein. (790 aa)
RPA4Replication protein A4. (233 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1522 aa)
TDRD3Tudor domain containing 3. (727 aa)
RMI2Uncharacterized protein. (136 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (338 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
FBH1F-box DNA helicase 1. (1078 aa)
WRNWRN RecQ like helicase. (1386 aa)
MEIOBMeiosis specific with OB-fold. (447 aa)
ENSANAP00000034595SAE2 domain-containing protein. (96 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (957 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (744 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (239 aa)
ENSANAP00000039680Uncharacterized protein. (120 aa)
CLSPNClaspin. (1353 aa)
ENSANAP00000040885Uncharacterized protein. (237 aa)
RAD51BRAD51 paralog B. (426 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
BLMBLM RecQ like helicase. (1415 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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