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LOC105717180 LOC105717180 SMARCAL1 SMARCAL1 NSMCE2 NSMCE2 LOC105713213 LOC105713213 TELO2 TELO2 NBN NBN DNA2 DNA2 STN1 STN1 BLM BLM PARP3 PARP3 RAD51 RAD51 INO80E INO80E RAD50 RAD50 RUVBL2 RUVBL2 UCHL5 UCHL5 DCLRE1B DCLRE1B TERF2 TERF2 XRCC6 XRCC6 PCNA PCNA ZNF365 ZNF365 ZSCAN4 ZSCAN4 POT1 POT1 NOP10 NOP10 CTC1 CTC1 RAD51C RAD51C TERF2IP TERF2IP WRAP53 WRAP53 SMC5 SMC5 RFC1 RFC1 PIF1 PIF1 TPRKB TPRKB SLX4 SLX4 ENSANAP00000015646 ENSANAP00000015646 BRCA2 BRCA2 ATR ATR TFPT TFPT RIF1 RIF1 ZBTB48 ZBTB48 INO80B INO80B RECQL4 RECQL4 UPF1 UPF1 HUS1 HUS1 ATM ATM LOC110567027 LOC110567027 RPA1 RPA1 NHP2 NHP2 DCLRE1A DCLRE1A DKC1 DKC1 FBXO4 FBXO4 GAR1 GAR1 TINF2 TINF2 NFRKB NFRKB RPA3 RPA3 LTO1 LTO1 CCNE2 CCNE2 EXO1 EXO1 CCNE1 CCNE1 LOC105732929 LOC105732929 RTEL1 RTEL1 ACTL6A ACTL6A MCRS1 MCRS1 XRCC5 XRCC5 LOC105721688 LOC105721688 ACTR8 ACTR8 XRCC3 XRCC3 PRKDC PRKDC LOC105708097 LOC105708097 SHLD1 SHLD1 TEP1 TEP1 MAD2L2 MAD2L2 ERCC1 ERCC1 INO80D INO80D ERCC4 ERCC4 APEX1 APEX1 SLX1A SLX1A ZNF827 ZNF827 ENSANAP00000025382 ENSANAP00000025382 LOC105727318 LOC105727318 ENSANAP00000027418 ENSANAP00000027418 XRCC4 XRCC4 TERT TERT SMC6 SMC6 INO80 INO80 RUVBL1 RUVBL1 PARP1 PARP1 WRN WRN SP100 SP100 ACD ACD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105717180Uncharacterized protein; Belongs to the CGI121/TPRKB family. (100 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (957 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa)
LOC105713213SAP domain-containing protein. (561 aa)
TELO2Telomere maintenance 2. (940 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (744 aa)
DNA2DNA replication helicase/nuclease 2. (936 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
BLMBLM RecQ like helicase. (1415 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
INO80EINO80 complex subunit E. (244 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (477 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (362 aa)
DCLRE1BDNA cross-link repair 1B. (531 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (534 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ZNF365Zinc finger protein 365. (408 aa)
ZSCAN4Zinc finger and SCAN domain containing 4. (433 aa)
POT1Protection of telomeres 1. (648 aa)
NOP10Uncharacterized protein. (64 aa)
CTC1CST telomere replication complex component 1. (1214 aa)
RAD51CRAD51 paralog C. (367 aa)
TERF2IPTERF2 interacting protein. (399 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
SMC5SMC_N domain-containing protein. (1102 aa)
RFC1Replication factor C subunit 1. (1136 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (678 aa)
TPRKBTP53RK binding protein; Belongs to the CGI121/TPRKB family. (167 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1804 aa)
ENSANAP00000015646Ku_C domain-containing protein. (263 aa)
BRCA2BRCA2 DNA repair associated. (3404 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2642 aa)
TFPTTCF3 fusion partner. (253 aa)
RIF1Replication timing regulatory factor 1. (2468 aa)
ZBTB48Zinc finger and BTB domain containing 48. (687 aa)
INO80BPAPA-1 domain-containing protein. (356 aa)
RECQL4RecQ like helicase 4. (1208 aa)
UPF1UPF1 RNA helicase and ATPase. (1092 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
LOC110567027SAP domain-containing protein. (565 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
DCLRE1ADNA cross-link repair 1A. (848 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
FBXO4F-box protein 4. (390 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (248 aa)
TINF2TERF1 interacting nuclear factor 2. (449 aa)
NFRKBNuclear factor related to kappaB binding protein. (1324 aa)
RPA3Replication protein A3. (134 aa)
LTO1LTO1 maturation factor of ABCE1. (189 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
EXO1Exonuclease 1. (848 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
LOC105732929SAP domain-containing protein. (557 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1325 aa)
ACTL6AActin like 6A; Belongs to the actin family. (363 aa)
MCRS1Microspherule protein 1. (475 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
LOC105721688Cyclin_C domain-containing protein; Belongs to the cyclin family. (384 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (398 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4076 aa)
LOC105708097G-patch domain-containing protein. (305 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
TEP1Telomerase associated protein 1. (2623 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (224 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (303 aa)
INO80DINO80 complex subunit D. (1027 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
ZNF827Zinc finger protein 827. (1114 aa)
ENSANAP00000025382Uncharacterized protein. (67 aa)
LOC105727318H/ACA ribonucleoprotein complex subunit 3. (64 aa)
ENSANAP00000027418Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1095 aa)
SMC6Structural maintenance of chromosomes 6. (1097 aa)
INO80INO80 complex ATPase subunit. (1557 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
PARP1Poly [ADP-ribose] polymerase. (1040 aa)
WRNWRN RecQ like helicase. (1386 aa)
SP100SP100 nuclear antigen. (867 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (502 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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