STRINGSTRING
SH3GL3 SH3GL3 SERPINA5 SERPINA5 LYZL4 LYZL4 FAM170B FAM170B TBXA2R TBXA2R ARC ARC RAB2B RAB2B ENSANAP00000003122 ENSANAP00000003122 VPS13B VPS13B MFGE8 MFGE8 DLD DLD CAV2 CAV2 GOLGA1 GOLGA1 CALCR CALCR TSSK3 TSSK3 C7orf61 C7orf61 TEX101 TEX101 GNAT3 GNAT3 CAPN11 CAPN11 PRSS55 PRSS55 POMT1 POMT1 CCDC136 CCDC136 HEXB HEXB ENKUR ENKUR SPACA1 SPACA1 RCBTB2 RCBTB2 SPAG17 SPAG17 CXADR CXADR BSG BSG TBC1D21 TBC1D21 FLOT2 FLOT2 HYAL3 HYAL3 ENSANAP00000012634 ENSANAP00000012634 PCSK4 PCSK4 TMEM190 TMEM190 ZPBP ZPBP ENSANAP00000013499 ENSANAP00000013499 IQCF5 IQCF5 ENSANAP00000013904 ENSANAP00000013904 SPATA16 SPATA16 CD46 CD46 NOTCH1 NOTCH1 TCP11 TCP11 NCF2 NCF2 LRGUK LRGUK PRSS37 PRSS37 SPAG9 SPAG9 SPACA6 SPACA6 CFAP65 CFAP65 TMPRSS12 TMPRSS12 SPAG8 SPAG8 CATSPER3 CATSPER3 SV2B SV2B SPAM1 SPAM1 IZUMO1 IZUMO1 MROH2B MROH2B ENSANAP00000020173 ENSANAP00000020173 SPACA7 SPACA7 CLK3 CLK3 PLA1A PLA1A CAV1 CAV1 ENSANAP00000021305 ENSANAP00000021305 SPATA1 SPATA1 TMEM95 TMEM95 ITGA1 ITGA1 ENSANAP00000022343 ENSANAP00000022343 TRIP11 TRIP11 GLIPR1L1 GLIPR1L1 TSSK4 TSSK4 KNL1 KNL1 ENSANAP00000023720 ENSANAP00000023720 ADAM15 ADAM15 STK31 STK31 AKAP3 AKAP3 CTNNA1 CTNNA1 SPESP1 SPESP1 CCDC189 CCDC189 BMF BMF SPAG6 SPAG6 IQUB IQUB PPFIA3 PPFIA3 SYT8 SYT8 ENSANAP00000029149 ENSANAP00000029149 TEKT3 TEKT3 CRCP CRCP SCNN1A SCNN1A ENSANAP00000029484 ENSANAP00000029484 PLA2G10 PLA2G10 ACRBP ACRBP CYLC1 CYLC1 ENSANAP00000030329 ENSANAP00000030329 CEP131 CEP131 SPACA9 SPACA9 LOC105733239 LOC105733239 LOC105713215 LOC105713215 IQCF1 IQCF1 DPEP3 DPEP3 ENSANAP00000033145 ENSANAP00000033145 LOXL1 LOXL1 LYZL6 LYZL6 MORN2 MORN2 FABP9 FABP9 ATP6V0A2 ATP6V0A2 ENSANAP00000034166 ENSANAP00000034166 TRIM36 TRIM36 SPACA3 SPACA3 RAB2A RAB2A TMEM225 TMEM225 ENSANAP00000036701 ENSANAP00000036701 ZPBP2 ZPBP2 SEPTIN14 SEPTIN14 VEZT VEZT RACGAP1 RACGAP1 SNAPIN SNAPIN TEX22 TEX22 KIAA1210 KIAA1210 ACR ACR ARSA ARSA CSNK2A2 CSNK2A2 DKKL1 DKKL1 ABHD2 ABHD2 IFT20 IFT20 IL4I1 IL4I1 SPINK2 SPINK2 CATSPER4 CATSPER4 RND2 RND2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
SERPINA5Serpin family A member 5; Belongs to the serpin family. (400 aa)
LYZL4Lysozyme like 4; Belongs to the glycosyl hydrolase 22 family. (146 aa)
FAM170BFamily with sequence similarity 170 member B. (284 aa)
TBXA2RThromboxane A2 receptor. (357 aa)
ARCActivity regulated cytoskeleton associated protein. (398 aa)
RAB2BRAB2B, member RAS oncogene family. (216 aa)
ENSANAP00000003122Uncharacterized protein. (207 aa)
VPS13BVacuolar protein sorting 13 homolog B. (4030 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (387 aa)
DLDDihydrolipoyl dehydrogenase. (531 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
GOLGA1Golgin A1. (767 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (474 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
C7orf61Chromosome 7 open reading frame 61. (161 aa)
TEX101Testis expressed 101. (262 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
CAPN11Calpain 11; Belongs to the peptidase C2 family. (717 aa)
PRSS55Serine protease 55; Belongs to the peptidase S1 family. (353 aa)
POMT1Protein O-mannosyltransferase 1. (737 aa)
CCDC136Coiled-coil domain containing 136. (1145 aa)
HEXBBeta-hexosaminidase. (528 aa)
ENKUREnkurin domain-containing protein. (256 aa)
SPACA1Sperm acrosome associated 1. (296 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
SPAG17Sperm associated antigen 17. (2217 aa)
CXADRCXADR Ig-like cell adhesion molecule. (354 aa)
BSGBasigin (Ok blood group). (385 aa)
TBC1D21TBC1 domain family member 21. (336 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (483 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
ENSANAP00000012634WAP domain-containing protein. (77 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (736 aa)
TMEM190Transmembrane protein 190. (176 aa)
ZPBPZona pellucida binding protein. (350 aa)
ENSANAP00000013499ACTL7A_N domain-containing protein; Belongs to the actin family. (442 aa)
IQCF5IQ motif containing F5. (148 aa)
ENSANAP00000013904Peptidase S1 domain-containing protein. (152 aa)
SPATA16Spermatogenesis associated 16. (570 aa)
CD46Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (326 aa)
NOTCH1Notch receptor 1. (2527 aa)
TCP11T-complex 11. (501 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
LRGUKLeucine rich repeats and guanylate kinase domain containing. (828 aa)
PRSS37Serine protease 37. (235 aa)
SPAG9Sperm associated antigen 9. (1338 aa)
SPACA6Sperm acrosome associated 6. (324 aa)
CFAP65Cilia and flagella associated protein 65. (1907 aa)
TMPRSS12Transmembrane serine protease 12. (243 aa)
SPAG8Sperm associated antigen 8. (452 aa)
CATSPER3Cation channel sperm associated 3. (397 aa)
SV2BSynaptic vesicle glycoprotein 2B. (683 aa)
SPAM1Hyaluronidase. (512 aa)
IZUMO1Izumo sperm-egg fusion 1. (358 aa)
MROH2BMaestro heat like repeat family member 2B. (958 aa)
ENSANAP00000020173Uncharacterized protein. (180 aa)
SPACA7Sperm acrosome associated 7. (193 aa)
CLK3CDC like kinase 3. (638 aa)
PLA1APhospholipase A1 member A. (456 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSANAP00000021305Uncharacterized protein. (69 aa)
SPATA1Spermatogenesis associated 1. (387 aa)
TMEM95Transmembrane protein 95. (184 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1090 aa)
ENSANAP00000022343Uncharacterized protein. (406 aa)
TRIP11Thyroid hormone receptor interactor 11. (1980 aa)
GLIPR1L1GLIPR1 like 1; Belongs to the CRISP family. (241 aa)
TSSK4Testis specific serine kinase 4. (339 aa)
KNL1Kinetochore scaffold 1. (2118 aa)
ENSANAP00000023720Uncharacterized protein. (108 aa)
ADAM15ADAM metallopeptidase domain 15. (875 aa)
STK31Serine/threonine kinase 31. (1019 aa)
AKAP3A-kinase anchoring protein 3. (856 aa)
CTNNA1Catenin alpha 1. (945 aa)
SPESP1Sperm equatorial segment protein 1. (369 aa)
CCDC189Coiled-coil domain containing 189. (336 aa)
BMFBcl2 modifying factor. (184 aa)
SPAG6Sperm associated antigen 6. (484 aa)
IQUBIQ motif and ubiquitin domain containing. (791 aa)
PPFIA3PTPRF interacting protein alpha 3. (1250 aa)
SYT8Synaptotagmin 8. (392 aa)
ENSANAP00000029149Uncharacterized protein. (150 aa)
TEKT3Tektin 3. (490 aa)
CRCPCGRP receptor component. (148 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (726 aa)
ENSANAP00000029484Uncharacterized protein. (182 aa)
PLA2G10Phospholipase A(2). (165 aa)
ACRBPAcrosin binding protein. (533 aa)
CYLC1Cylicin_N domain-containing protein. (68 aa)
ENSANAP00000030329GRIP domain-containing protein. (402 aa)
CEP131Centrosomal protein 131. (1083 aa)
SPACA9Sperm acrosome associated 9. (226 aa)
LOC105733239Uncharacterized protein. (916 aa)
LOC105713215Uncharacterized protein. (277 aa)
IQCF1IQ motif containing F1. (205 aa)
DPEP3Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (476 aa)
ENSANAP00000033145Enkurin domain-containing protein. (204 aa)
LOXL1Lysyl oxidase like 1. (578 aa)
LYZL6Lysozyme like 6; Belongs to the glycosyl hydrolase 22 family. (148 aa)
MORN2MORN repeat containing 2. (79 aa)
FABP9Fatty acid binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (802 aa)
ENSANAP00000034166Nudix hydrolase domain-containing protein; Belongs to the Nudix hydrolase family. (173 aa)
TRIM36Tripartite motif containing 36. (738 aa)
SPACA3Sperm acrosome associated 3; Belongs to the glycosyl hydrolase 22 family. (211 aa)
RAB2ARAB2A, member RAS oncogene family. (212 aa)
TMEM225Transmembrane protein 225. (227 aa)
ENSANAP00000036701GRIP domain-containing protein. (1606 aa)
ZPBP2Zona pellucida binding protein 2. (337 aa)
SEPTIN14Septin 14; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (397 aa)
VEZTVezatin, adherens junctions transmembrane protein. (781 aa)
RACGAP1Rac GTPase activating protein 1. (594 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
TEX22Testis expressed 22. (152 aa)
KIAA1210KIAA1210. (1643 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (413 aa)
ARSAArylsulfatase A. (594 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
DKKL1Dickkopf like acrosomal protein 1. (241 aa)
ABHD2Abhydrolase domain containing 2. (442 aa)
IFT20Intraflagellar transport 20. (158 aa)
IL4I1Amine oxidase. (590 aa)
SPINK2Uncharacterized protein. (88 aa)
CATSPER4Cation channel sperm associated 4. (469 aa)
RND2Rho family GTPase 2. (227 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: low (12%) [HD]