STRINGSTRING
SERPINA5 SERPINA5 FAM170B FAM170B VPS13B VPS13B MFGE8 MFGE8 CAV2 CAV2 TEX101 TEX101 CCDC136 CCDC136 SPACA1 SPACA1 BSG BSG FLOT2 FLOT2 HYAL3 HYAL3 PCSK4 PCSK4 TMEM190 TMEM190 ZPBP ZPBP CD46 CD46 SPACA6 SPACA6 IZUMO1 IZUMO1 ENSANAP00000020173 ENSANAP00000020173 PLA1A PLA1A CAV1 CAV1 TMEM95 TMEM95 TRIP11 TRIP11 TEKT3 TEKT3 ACRBP ACRBP ENSANAP00000030329 ENSANAP00000030329 SPACA3 SPACA3 TMEM225 TMEM225 ENSANAP00000036701 ENSANAP00000036701 RND2 RND2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINA5Serpin family A member 5; Belongs to the serpin family. (400 aa)
FAM170BFamily with sequence similarity 170 member B. (284 aa)
VPS13BVacuolar protein sorting 13 homolog B. (4030 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (387 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
TEX101Testis expressed 101. (262 aa)
CCDC136Coiled-coil domain containing 136. (1145 aa)
SPACA1Sperm acrosome associated 1. (296 aa)
BSGBasigin (Ok blood group). (385 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (483 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (736 aa)
TMEM190Transmembrane protein 190. (176 aa)
ZPBPZona pellucida binding protein. (350 aa)
CD46Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (326 aa)
SPACA6Sperm acrosome associated 6. (324 aa)
IZUMO1Izumo sperm-egg fusion 1. (358 aa)
ENSANAP00000020173Uncharacterized protein. (180 aa)
PLA1APhospholipase A1 member A. (456 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
TMEM95Transmembrane protein 95. (184 aa)
TRIP11Thyroid hormone receptor interactor 11. (1980 aa)
TEKT3Tektin 3. (490 aa)
ACRBPAcrosin binding protein. (533 aa)
ENSANAP00000030329GRIP domain-containing protein. (402 aa)
SPACA3Sperm acrosome associated 3; Belongs to the glycosyl hydrolase 22 family. (211 aa)
TMEM225Transmembrane protein 225. (227 aa)
ENSANAP00000036701GRIP domain-containing protein. (1606 aa)
RND2Rho family GTPase 2. (227 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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