STRINGSTRING
SMURF1 SMURF1 CLN6 CLN6 UBQLN2 UBQLN2 ENSANAP00000026961 ENSANAP00000026961 ZFYVE26 ZFYVE26 ARFIP2 ARFIP2 UBXN2A UBXN2A ATG9A ATG9A VIPAS39 VIPAS39 RAB19 RAB19 ARL8A ARL8A ULK1 ULK1 WIPI2 WIPI2 ENSANAP00000025583 ENSANAP00000025583 BAG3 BAG3 ATP6V0C ATP6V0C ATP6V1F ATP6V1F MTOR MTOR ACPP ACPP CLN8 CLN8 ENSANAP00000024413 ENSANAP00000024413 ENSANAP00000024008 ENSANAP00000024008 RAB7A RAB7A IRGM IRGM GRN GRN LOC105714402 LOC105714402 ATG16L2 ATG16L2 ENSANAP00000000340 ENSANAP00000000340 ENSANAP00000038942 ENSANAP00000038942 LRRK2 LRRK2 ATP6AP2 ATP6AP2 ENSANAP00000039107 ENSANAP00000039107 ATG2A ATG2A LYST LYST STING1 STING1 ATF2 ATF2 ATP6V0B ATP6V0B AMBRA1 AMBRA1 ENSANAP00000040580 ENSANAP00000040580 MBTPS1 MBTPS1 LAMTOR1 LAMTOR1 CORO1A CORO1A BECN1 BECN1 ENSANAP00000042290 ENSANAP00000042290 CXorf21 CXorf21 HOOK2 HOOK2 ENSANAP00000000821 ENSANAP00000000821 LOC105714403 LOC105714403 ATP6V1H ATP6V1H VPS33A VPS33A TMEM106B TMEM106B WIPI1 WIPI1 LOC105714732 LOC105714732 LOC105732615 LOC105732615 ENSANAP00000002889 ENSANAP00000002889 PIK3C2B PIK3C2B LOC105717178 LOC105717178 SYT7 SYT7 HOOK3 HOOK3 RAB7B RAB7B LAPTM5 LAPTM5 RAB1A RAB1A RAB20 RAB20 ARL8B ARL8B TPP1 TPP1 ATG4B ATG4B MAP1LC3C MAP1LC3C RB1CC1 RB1CC1 VPS16 VPS16 TMEM165 TMEM165 WDR45B WDR45B GABARAPL2 GABARAPL2 EXT1 EXT1 MAP1LC3A MAP1LC3A HEXB HEXB ATP10B ATP10B TPCN2 TPCN2 CLVS2 CLVS2 ATP13A2 ATP13A2 VMP1 VMP1 SYNPO2 SYNPO2 ENSANAP00000009192 ENSANAP00000009192 RUFY4 RUFY4 ULK2 ULK2 ATG5 ATG5 SRPX SRPX VPS18 VPS18 PACS2 PACS2 ENSANAP00000010068 ENSANAP00000010068 CHMP4B CHMP4B ATG12 ATG12 VPS4A VPS4A NAGPA NAGPA MYO7A MYO7A P2RX7 P2RX7 TRAPPC8 TRAPPC8 STBD1 STBD1 RAB34 RAB34 CCDC115 CCDC115 LOC105707715 LOC105707715 ATG14 ATG14 ENSANAP00000013578 ENSANAP00000013578 ENSANAP00000013693 ENSANAP00000013693 GNPTAB GNPTAB CHMP4C CHMP4C LAPTM4A LAPTM4A TMEM199 TMEM199 ATP2A2 ATP2A2 ATG9B ATG9B MFN2 MFN2 ATG3 ATG3 LOC105716563-2 LOC105716563-2 VPS11 VPS11 MAP1LC3B MAP1LC3B FIG4 FIG4 PSEN1 PSEN1 PPT1 PPT1 TMEM41B TMEM41B ZKSCAN3 ZKSCAN3 CHMP2A CHMP2A ATG101 ATG101 CLN5 CLN5 ATG4D ATG4D RAB23 RAB23 VPS33B VPS33B RAB33B RAB33B LOC105726358 LOC105726358 ENSANAP00000020140 ENSANAP00000020140 KIAA1324 KIAA1324 ARSB ARSB GBA GBA ENSANAP00000022830 ENSANAP00000022830 LOC105731273 LOC105731273 CHMP5 CHMP5 WDR45 WDR45 NAGLU NAGLU ATG13 ATG13 STX17 STX17 LRBA LRBA SNAPIN SNAPIN TP53INP2 TP53INP2 NSFL1C NSFL1C CLVS1 CLVS1 MFSD8 MFSD8 ATP6AP1 ATP6AP1 ATG2B ATG2B TFEB TFEB AP3B1 AP3B1 PIK3C3 PIK3C3 RAB43 RAB43 ATG16L1 ATG16L1 FAM160A2 FAM160A2 RNASEK RNASEK ENSANAP00000035554 ENSANAP00000035554 RASEF RASEF MAN2A1 MAN2A1 VPS35 VPS35 TMEM130 TMEM130 PIKFYVE PIKFYVE STX12 STX12 UBXN2B UBXN2B HPS4 HPS4 ENSANAP00000033645 ENSANAP00000033645 TP53INP1 TP53INP1 SPG11 SPG11 TMEM9 TMEM9 ULK3 ULK3 ABCA1 ABCA1 HOOK1 HOOK1 PLA2G5 PLA2G5 ENSANAP00000030027 ENSANAP00000030027 ACP2 ACP2 RAB39A RAB39A TMEM175 TMEM175 AKTIP AKTIP CLN3 CLN3 AP4M1 AP4M1 ACP4 ACP4 EPM2A EPM2A ENSANAP00000028641 ENSANAP00000028641 TCIRG1 TCIRG1 ENSANAP00000028254 ENSANAP00000028254
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMURF1E3 ubiquitin-protein ligase. (757 aa)
CLN6CLN6 transmembrane ER protein. (341 aa)
UBQLN2Ubiquilin 2. (624 aa)
ENSANAP00000026961Uncharacterized protein. (236 aa)
ZFYVE26Zinc finger FYVE-type containing 26. (2506 aa)
ARFIP2ADP ribosylation factor interacting protein 2. (373 aa)
UBXN2AUBX domain protein 2A. (297 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (866 aa)
VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (488 aa)
RAB19RAB19, member RAS oncogene family. (217 aa)
ARL8AADP ribosylation factor like GTPase 8A; Belongs to the small GTPase superfamily. Arf family. (186 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1040 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (456 aa)
ENSANAP00000025583Uncharacterized protein. (192 aa)
BAG3BCL2 associated athanogene 3. (575 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ACPPAcid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (418 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
ENSANAP00000024413Uncharacterized protein. (298 aa)
ENSANAP00000024008Uncharacterized protein. (137 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
IRGMImmunity related GTPase M. (188 aa)
GRNGranulin precursor. (592 aa)
LOC105714402Uncharacterized protein. (110 aa)
ATG16L2Autophagy related 16 like 2. (623 aa)
ENSANAP00000000340Uncharacterized protein. (114 aa)
ENSANAP00000038942Uncharacterized protein. (48 aa)
LRRK2Leucine rich repeat kinase 2. (2515 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
ENSANAP00000039107Uncharacterized protein. (70 aa)
ATG2AAutophagy related 2A. (1966 aa)
LYSTLysosomal trafficking regulator. (3802 aa)
STING1Transmembrane protein 173. (327 aa)
ATF2Activating transcription factor 2. (287 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (252 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1289 aa)
ENSANAP00000040580Uncharacterized protein. (302 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1052 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
BECN1Beclin 1. (453 aa)
ENSANAP00000042290Uncharacterized protein. (189 aa)
CXorf21Chromosome X open reading frame 21. (298 aa)
HOOK2Hook microtubule tethering protein 2. (717 aa)
ENSANAP00000000821Uncharacterized protein. (278 aa)
LOC105714403ER membrane protein complex subunit 6. (110 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (475 aa)
VPS33AUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (576 aa)
TMEM106BTransmembrane protein 106B. (274 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (434 aa)
LOC105714732V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (112 aa)
LOC105732615Uncharacterized protein. (234 aa)
ENSANAP00000002889Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (746 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1633 aa)
LOC105717178V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
SYT7Synaptotagmin 7. (686 aa)
HOOK3Calponin-homology (CH) domain-containing protein. (718 aa)
RAB7BRAB7B, member RAS oncogene family. (202 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
RAB1AUncharacterized protein. (205 aa)
RAB20RAB20, member RAS oncogene family. (222 aa)
ARL8BADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (244 aa)
TPP1Tripeptidyl peptidase 1. (572 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (147 aa)
RB1CC1RB1 inducible coiled-coil 1. (1562 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
TMEM165GDT1 family protein. (324 aa)
WDR45BWD repeat domain 45B. (344 aa)
GABARAPL2Uncharacterized protein. (117 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (124 aa)
HEXBBeta-hexosaminidase. (528 aa)
ATP10BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1521 aa)
TPCN2Two pore segment channel 2. (752 aa)
CLVS2Clavesin 2. (327 aa)
ATP13A2ATPase cation transporting 13A2. (1094 aa)
VMP1Vacuole membrane protein 1. (446 aa)
SYNPO2Synaptopodin 2. (1265 aa)
ENSANAP00000009192Uncharacterized protein. (103 aa)
RUFY4RUN and FYVE domain containing 4. (600 aa)
ULK2Unc-51 like autophagy activating kinase 2. (593 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
SRPXSushi repeat containing protein X-linked. (463 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (973 aa)
PACS2Phosphofurin acidic cluster sorting protein 2. (888 aa)
ENSANAP00000010068Calponin-homology (CH) domain-containing protein. (716 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (492 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (515 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2210 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
TRAPPC8Trafficking protein particle complex 8. (1437 aa)
STBD1Starch binding domain 1. (332 aa)
RAB34RAB34, member RAS oncogene family. (268 aa)
CCDC115Coiled-coil domain containing 115. (180 aa)
LOC105707715Uncharacterized protein. (407 aa)
ATG14Autophagy related 14. (492 aa)
ENSANAP00000013578Uncharacterized protein. (221 aa)
ENSANAP00000013693Uncharacterized protein. (110 aa)
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1198 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
LAPTM4AUncharacterized protein. (191 aa)
TMEM199Transmembrane protein 199. (208 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (923 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
ATG3Autophagy-related protein 3. (288 aa)
LOC105716563-2Beta-hexosaminidase. (541 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
MAP1LC3BUncharacterized protein. (128 aa)
FIG4FIG4 phosphoinositide 5-phosphatase. (907 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
PPT1Palmitoyl-protein thioesterase 1. (306 aa)
TMEM41BTransmembrane protein 41B. (243 aa)
ZKSCAN3Zinc finger with KRAB and SCAN domains 3. (538 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
ATG101Autophagy related 101. (218 aa)
CLN5Uncharacterized protein. (397 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (442 aa)
RAB23Uncharacterized protein. (237 aa)
VPS33BUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (611 aa)
RAB33BRAB33B, member RAS oncogene family. (229 aa)
LOC105726358Uncharacterized protein. (202 aa)
ENSANAP00000020140Uncharacterized protein. (67 aa)
KIAA1324KIAA1324. (1016 aa)
ARSBArylsulfatase B. (534 aa)
GBAGlucosylceramidase. (529 aa)
ENSANAP00000022830Autophagy-related protein 3. (282 aa)
LOC105731273Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (672 aa)
CHMP5Uncharacterized protein. (219 aa)
WDR45Uncharacterized protein. (360 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (742 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
LRBALPS responsive beige-like anchor protein. (2850 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
NSFL1CNSFL1 cofactor. (372 aa)
CLVS1Clavesin 1. (354 aa)
MFSD8Major facilitator superfamily domain containing 8. (518 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (466 aa)
ATG2BAutophagy related 2B. (2078 aa)
TFEBTranscription factor EB. (554 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (892 aa)
RAB43RAB43, member RAS oncogene family. (212 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
FAM160A2Family with sequence similarity 160 member A2. (972 aa)
RNASEKRibonuclease K. (137 aa)
ENSANAP00000035554Uncharacterized protein. (151 aa)
RASEFRAS and EF-hand domain containing. (740 aa)
MAN2A1Alpha-mannosidase. (1144 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (803 aa)
TMEM130Transmembrane protein 130. (435 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
UBXN2BUBX domain protein 2B. (318 aa)
HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (708 aa)
ENSANAP00000033645Autophagy_N domain-containing protein. (132 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (214 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2437 aa)
TMEM9Transmembrane protein 9. (183 aa)
ULK3Unc-51 like kinase 3. (481 aa)
ABCA1ATP binding cassette subfamily A member 1. (2220 aa)
HOOK1Hook microtubule tethering protein 1. (730 aa)
PLA2G5Phospholipase A(2). (138 aa)
ENSANAP00000030027Uncharacterized protein. (621 aa)
ACP2Acid phosphatase 2, lysosomal; Belongs to the histidine acid phosphatase family. (423 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
TMEM175Transmembrane protein 175. (494 aa)
AKTIPAKT interacting protein. (293 aa)
CLN3Battenin. (422 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
ACP4Acid phosphatase 4; Belongs to the histidine acid phosphatase family. (428 aa)
EPM2AEPM2A glucan phosphatase, laforin. (330 aa)
ENSANAP00000028641Uncharacterized protein. (177 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (828 aa)
ENSANAP00000028254Uncharacterized protein. (57 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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