Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABRAXAS1 | ATM | ENSANAP00000037859 | ENSANAP00000011320 | Abraxas 1, BRCA1 A complex subunit. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.640 |
| ABRAXAS1 | BABAM1 | ENSANAP00000037859 | ENSANAP00000021207 | Abraxas 1, BRCA1 A complex subunit. | BRISC and BRCA1 A complex member 1. | 0.997 |
| ABRAXAS1 | BABAM2 | ENSANAP00000037859 | ENSANAP00000024142 | Abraxas 1, BRCA1 A complex subunit. | BRISC and BRCA1 A complex member 2. | 0.995 |
| ABRAXAS1 | BARD1 | ENSANAP00000037859 | ENSANAP00000018263 | Abraxas 1, BRCA1 A complex subunit. | BRCA1 associated RING domain 1. | 0.990 |
| ABRAXAS1 | BRCA1 | ENSANAP00000037859 | ENSANAP00000004329 | Abraxas 1, BRCA1 A complex subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.997 |
| ABRAXAS1 | BRCC3 | ENSANAP00000037859 | ENSANAP00000014002 | Abraxas 1, BRCA1 A complex subunit. | BRCA1/BRCA2-containing complex subunit 3. | 0.998 |
| ABRAXAS1 | CHEK2 | ENSANAP00000037859 | ENSANAP00000007104 | Abraxas 1, BRCA1 A complex subunit. | Checkpoint kinase 2. | 0.634 |
| ABRAXAS1 | NABP2 | ENSANAP00000037859 | ENSANAP00000005253 | Abraxas 1, BRCA1 A complex subunit. | Nucleic acid binding protein 2. | 0.686 |
| ABRAXAS1 | PAXIP1 | ENSANAP00000037859 | ENSANAP00000024881 | Abraxas 1, BRCA1 A complex subunit. | PAX interacting protein 1. | 0.607 |
| ABRAXAS1 | RNF168 | ENSANAP00000037859 | ENSANAP00000027700 | Abraxas 1, BRCA1 A complex subunit. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.796 |
| ABRAXAS1 | RNF8 | ENSANAP00000037859 | ENSANAP00000028451 | Abraxas 1, BRCA1 A complex subunit. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.653 |
| ABRAXAS1 | TP53BP1 | ENSANAP00000037859 | ENSANAP00000001388 | Abraxas 1, BRCA1 A complex subunit. | Tumor protein p53 binding protein 1. | 0.619 |
| ABRAXAS1 | UIMC1 | ENSANAP00000037859 | ENSANAP00000012531 | Abraxas 1, BRCA1 A complex subunit. | Ubiquitin interaction motif containing 1. | 0.992 |
| ATM | ABRAXAS1 | ENSANAP00000011320 | ENSANAP00000037859 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Abraxas 1, BRCA1 A complex subunit. | 0.640 |
| ATM | ATR | ENSANAP00000011320 | ENSANAP00000015001 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.999 |
| ATM | BABAM1 | ENSANAP00000011320 | ENSANAP00000021207 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRISC and BRCA1 A complex member 1. | 0.620 |
| ATM | BABAM2 | ENSANAP00000011320 | ENSANAP00000024142 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRISC and BRCA1 A complex member 2. | 0.671 |
| ATM | BARD1 | ENSANAP00000011320 | ENSANAP00000018263 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCA1 associated RING domain 1. | 0.992 |
| ATM | BCL2 | ENSANAP00000011320 | ENSANAP00000030335 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BCL2 apoptosis regulator. | 0.409 |
| ATM | BLM | ENSANAP00000011320 | ENSANAP00000042251 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BLM RecQ like helicase. | 0.959 |
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