STRINGSTRING
FOXP1 FOXP1 IQSEC1 IQSEC1 PROX1 PROX1 ROCK2 ROCK2 TSTA3 TSTA3 GATA2 GATA2 FGF18 FGF18 MAP2K3 MAP2K3 RREB1 RREB1 CLASP2 CLASP2 SRPX2 SRPX2 NUS1 NUS1 EPB41L4B EPB41L4B GRN GRN BMPR2 BMPR2 HYAL1 HYAL1 ENSANAP00000023981 ENSANAP00000023981 MAP4K4 MAP4K4 ANXA1 ANXA1 ABL1 ABL1 FGF1 FGF1 WNT5A WNT5A MTOR MTOR FLT4 FLT4 PRKD2 PRKD2 GATA3 GATA3 TEK TEK RRAS RRAS ITGA3 ITGA3 SP1 SP1 PIK3CD PIK3CD AKT3 AKT3 SASH1 SASH1 PLK2 PLK2 ENSANAP00000028003 ENSANAP00000028003 HMOX1 HMOX1 MMP9 MMP9 TGFB2 TGFB2 KDR KDR ATP5F1B ATP5F1B DOCK5 DOCK5 PRKD1 PRKD1 WNT7A WNT7A ANGPT4 ANGPT4 RIN2 RIN2 DOCK1 DOCK1 SRC SRC NRP2 NRP2 PRKCA PRKCA ADAM9 ADAM9 AAMP AAMP PTK2B PTK2B NRP1 NRP1 LOC105728839 LOC105728839 SCARB1 SCARB1 ITGB1BP1 ITGB1BP1 BCAS3 BCAS3 PIK3CG PIK3CG JCAD JCAD EMC10 EMC10 FGF7 FGF7 TGFB1 TGFB1 BMP4 BMP4 SIRT1 SIRT1 RAB25 RAB25 PDGFB PDGFB PLCG1 PLCG1 CCBE1 CCBE1 ZNF580 ZNF580 IFNG IFNG ZC3H12A ZC3H12A THBS1 THBS1 ARF6 ARF6 HIF1A HIF1A PPM1F PPM1F RHOB RHOB AMOT AMOT PDPK1 PDPK1 VIL1 VIL1 ATP5F1A ATP5F1A ADGRA2 ADGRA2 RTN4 RTN4 CTSH CTSH ENSANAP00000006063 ENSANAP00000006063 ENSANAP00000006275 ENSANAP00000006275 HDAC6 HDAC6 SEMA5A SEMA5A CALR CALR FGFR1 FGFR1 AGT AGT TDGF1 TDGF1 SPARC SPARC HAS2 HAS2 PIK3CB PIK3CB EPB41L5 EPB41L5 VEGFA VEGFA ENSANAP00000009176 ENSANAP00000009176 LGMN LGMN NOS3 NOS3 BCAR1 BCAR1 ANGPT1 ANGPT1 VEGFC VEGFC TACR1 TACR1 HDAC9 HDAC9 ENSANAP00000039148 ENSANAP00000039148 FGF16 FGF16 ADAM17 ADAM17 FOXC2 FOXC2 FGF2 FGF2 ATOH8 ATOH8 RHOJ RHOJ HSPB1 HSPB1 CIB1 CIB1 FGF10 FGF10 MET MET ENSANAP00000009960 ENSANAP00000009960 BSG BSG IRS2 IRS2 ALOX12 ALOX12 SOX9 SOX9 LOC105712414 LOC105712414 NFE2L2 NFE2L2 PTGS2 PTGS2 CAPN7 CAPN7 ETS1 ETS1 ENSANAP00000013254 ENSANAP00000013254 PRKCE PRKCE PLCG2 PLCG2 PLPP3 PLPP3 MAPRE2 MAPRE2 SMOC2 SMOC2 ANXA3 ANXA3 HBEGF HBEGF MAP3K3 MAP3K3 CLASP1 CLASP1 ITGA2 ITGA2 GPLD1 GPLD1 TGFBR2 TGFBR2 ENPP2 ENPP2 GLIPR2 GLIPR2 ITGB3 ITGB3 AKT1 AKT1 HDAC7 HDAC7 P2RX4 P2RX4 CD40 CD40 EGF EGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXP1Forkhead box P1. (693 aa)
IQSEC1IQ motif and Sec7 domain 1. (1115 aa)
PROX1Prospero homeobox 1. (737 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
TSTA3Epimerase domain-containing protein. (377 aa)
GATA2GATA binding protein 2. (470 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (392 aa)
RREB1Ras responsive element binding protein 1. (1736 aa)
CLASP2Uncharacterized protein. (1515 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
NUS1Uncharacterized protein. (293 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (903 aa)
GRNGranulin precursor. (592 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
HYAL1Hyaluronidase. (450 aa)
ENSANAP00000023981Epimerase domain-containing protein. (273 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1329 aa)
ANXA1Annexin. (346 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
PRKD2Protein kinase D2. (755 aa)
GATA3GATA binding protein 3. (409 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
RRASRAS related. (218 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1040 aa)
SP1Sp1 transcription factor. (779 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SASH1SAM and SH3 domain containing 1. (1221 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
ENSANAP00000028003SH3 domain-containing protein. (787 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (544 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1861 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (863 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ANGPT4Angiopoietin 4. (498 aa)
RIN2Ras and Rab interactor 2. (941 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1865 aa)
SRCTyrosine-protein kinase. (542 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ADAM9ADAM metallopeptidase domain 9. (820 aa)
AAMPAngio associated migratory cell protein. (434 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
LOC105728839Uncharacterized protein. (819 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (551 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (914 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
JCADJunctional cadherin 5 associated. (1349 aa)
EMC10ER membrane protein complex subunit 10. (359 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SIRT1Sirtuin 1. (751 aa)
RAB25RAB25, member RAS oncogene family. (213 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
ZNF580Zinc finger protein 580. (172 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
THBS1Thrombospondin 1. (1173 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (454 aa)
RHOBRas homolog family member B. (196 aa)
AMOTAngiomotin. (1083 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (572 aa)
VIL1Villin 1. (827 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (460 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1337 aa)
RTN4Reticulon. (1153 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (299 aa)
ENSANAP00000006063SH2 domain-containing protein. (230 aa)
ENSANAP00000006275Uncharacterized protein. (133 aa)
HDAC6Histone deacetylase 6. (1226 aa)
SEMA5ASemaphorin 5A. (1074 aa)
CALRCalreticulin. (424 aa)
FGFR1Fibroblast growth factor receptor 1. (962 aa)
AGTAngiotensinogen; Belongs to the serpin family. (514 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (186 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
HAS2Hyaluronan synthase 2. (552 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (412 aa)
ENSANAP00000009176Reticulon. (340 aa)
LGMNLegumain. (433 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
BCAR1SH3 domain-containing protein. (920 aa)
ANGPT1Angiopoietin 1. (498 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (424 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1092 aa)
ENSANAP00000039148SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (225 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ADAM17ADAM metallopeptidase domain 17. (787 aa)
FOXC2Forkhead box C2. (489 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
ATOH8Atonal bHLH transcription factor 8. (351 aa)
RHOJRas homolog family member J. (214 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
CIB1Calcium and integrin binding 1. (231 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1391 aa)
ENSANAP00000009960PID domain-containing protein. (188 aa)
BSGBasigin (Ok blood group). (385 aa)
IRS2Insulin receptor substrate 2. (1369 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
SOX9SRY-box transcription factor 9. (505 aa)
LOC105712414SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (175 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CAPN7Calpain 7; Belongs to the peptidase C2 family. (813 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
ENSANAP00000013254Uncharacterized protein. (253 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
MAPRE2Microtubule associated protein RP/EB family member 2. (327 aa)
SMOC2SPARC related modular calcium binding 2. (461 aa)
ANXA3Annexin. (323 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (705 aa)
CLASP1Cytoplasmic linker associated protein 1. (1539 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1179 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (885 aa)
GLIPR2SCP domain-containing protein; Belongs to the CRISP family. (156 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1006 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (362 aa)
CD40CD40 molecule. (274 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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