STRINGSTRING
GLIPR2 GLIPR2 TGFB1 TGFB1 BAMBI BAMBI SPRED3 SPRED3 BMP2 BMP2 HDAC2 HDAC2 EPHA4 EPHA4 CTNNB1 CTNNB1 GCNT2 GCNT2 PTEN PTEN TIAM1 TIAM1 HPN HPN TGFB2 TGFB2 ENSANAP00000028458 ENSANAP00000028458 DACT3 DACT3 PDPN PDPN SMAD2 SMAD2 FERMT2 FERMT2 SPRY2 SPRY2 GATA3 GATA3 ALX1 ALX1 LEF1 LEF1 MDK MDK CRB2 CRB2 AXIN2 AXIN2 LRG1 LRG1 MTOR MTOR SDCBP SDCBP WWTR1 WWTR1 MAD2L2 MAD2L2 TGFB3 TGFB3 ENSANAP00000022622 ENSANAP00000022622 CLASP2 CLASP2 TBX20 TBX20 SNAI1 SNAI1 COL1A1 COL1A1 LOC105718807 LOC105718807 NKX2-1 NKX2-1 ZNF750 ZNF750 SMAD7 SMAD7 LDLRAD4 LDLRAD4 LOC105725023 LOC105725023 DAG1 DAG1 FOXC1 FOXC1 TGFBR2 TGFBR2 BMP5 BMP5 SDHAF2 SDHAF2 CLASP1 CLASP1 SMAD4 SMAD4 NOTCH1 NOTCH1 ZNF703 ZNF703 TGFB1I1 TGFB1I1 FOXA1 FOXA1 SPRED2 SPRED2 JAG1 JAG1 MCRIP1 MCRIP1 TGFBR1 TGFBR1 ENG ENG POFUT2 POFUT2 EFNA1 EFNA1 PAWR PAWR DAB2IP DAB2IP TRIM62 TRIM62 SFRP1 SFRP1 EZH2 EZH2 LOXL2 LOXL2 SFRP2 SFRP2 IL6 IL6 IL17RD IL17RD SPRY1 SPRY1 ISL1 ISL1 TBX5 TBX5 ELL3 ELL3 NOG NOG IL1B IL1B PHLDB2 PHLDB2 SMAD3 SMAD3 FOXA2 FOXA2 BMP4 BMP4 EMP2 EMP2 SPRED1 SPRED1 PHLDB1 PHLDB1 BMP7 BMP7 OLFM1 OLFM1 MARK1 MARK1 ENSANAP00000039594 ENSANAP00000039594 TCF7L2 TCF7L2 ACVR1 ACVR1 FUZ FUZ BCL9L BCL9L DAB2 DAB2 USF3 USF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLIPR2SCP domain-containing protein; Belongs to the CRISP family. (156 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SPRED3Sprouty related EVH1 domain containing 3. (456 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (465 aa)
EPHA4EPH receptor A4. (986 aa)
CTNNB1Catenin beta 1. (781 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1573 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ENSANAP00000028458C2H2-type domain-containing protein. (479 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (606 aa)
PDPNPodoplanin. (162 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FERMT2Fermitin family member 2. (706 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
GATA3GATA binding protein 3. (409 aa)
ALX1ALX homeobox 1. (326 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
MDKUncharacterized protein. (144 aa)
CRB2Crumbs cell polarity complex component 2. (1291 aa)
AXIN2Axin 2. (843 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (417 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SDCBPSyndecan binding protein. (316 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (224 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSANAP00000022622PTN_MK_N domain-containing protein. (72 aa)
CLASP2Uncharacterized protein. (1515 aa)
TBX20T-box transcription factor 20. (447 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
COL1A1Collagen type I alpha 1 chain. (1453 aa)
LOC105718807Eph LBD domain-containing protein. (271 aa)
NKX2-1NK2 homeobox 1. (402 aa)
ZNF750Zinc finger protein 750. (722 aa)
SMAD7Mothers against decapentaplegic homolog. (489 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
LOC105725023Uncharacterized protein. (336 aa)
DAG1Dystroglycan 1. (895 aa)
FOXC1Forkhead box C1. (539 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (171 aa)
CLASP1Cytoplasmic linker associated protein 1. (1539 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NOTCH1Notch receptor 1. (2527 aa)
ZNF703Uncharacterized protein. (540 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (463 aa)
FOXA1Forkhead box A1. (470 aa)
SPRED2Sprouty related EVH1 domain containing 2. (432 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MCRIP1MAPK regulated corepressor interacting protein 1. (109 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
ENGEndoglin. (440 aa)
POFUT2Protein O-fucosyltransferase 2. (410 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
PAWRPro-apoptotic WT1 regulator. (340 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
TRIM62Tripartite motif containing 62. (475 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
LOXL2Lysyl oxidase like 2. (869 aa)
SFRP2Secreted frizzled related protein 2. (296 aa)
IL6Interleukin 6. (213 aa)
IL17RDInterleukin 17 receptor D. (770 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
ISL1Uncharacterized protein. (349 aa)
TBX5T-box transcription factor 5. (518 aa)
ELL3Elongation factor for RNA polymerase II 3. (399 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1342 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
FOXA2Forkhead box A2. (463 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (159 aa)
SPRED1Sprouty related EVH1 domain containing 1. (447 aa)
PHLDB1Pleckstrin homology like domain family B member 1. (1377 aa)
BMP7Bone morphogenetic protein 7. (410 aa)
OLFM1Olfactomedin 1. (636 aa)
MARK1Non-specific serine/threonine protein kinase. (677 aa)
ENSANAP00000039594SER_THR_PHOSPHATASE domain-containing protein. (268 aa)
TCF7L2Transcription factor 7 like 2. (618 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
FUZFuzzy planar cell polarity protein. (360 aa)
BCL9LBCL9 like. (1497 aa)
DAB2DAB adaptor protein 2. (552 aa)
USF3Upstream transcription factor family member 3. (2235 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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