STRINGSTRING
IL1B IL1B OLFM1 OLFM1 BMP7 BMP7 EMP2 EMP2 BMP4 BMP4 TGFB1 TGFB1 BAMBI BAMBI BMP2 BMP2 HDAC2 HDAC2 CTNNB1 CTNNB1 GCNT2 GCNT2 TIAM1 TIAM1 TGFB2 TGFB2 ENSANAP00000028458 ENSANAP00000028458 PDPN PDPN SMAD2 SMAD2 FERMT2 FERMT2 ALX1 ALX1 LEF1 LEF1 MDK MDK CRB2 CRB2 AXIN2 AXIN2 LRG1 LRG1 MTOR MTOR SDCBP SDCBP WWTR1 WWTR1 TGFB3 TGFB3 ENSANAP00000022622 ENSANAP00000022622 TBX20 TBX20 SNAI1 SNAI1 COL1A1 COL1A1 LOC105725023 LOC105725023 GLIPR2 GLIPR2 FOXC1 FOXC1 TGFBR2 TGFBR2 SMAD4 SMAD4 NOTCH1 NOTCH1 ZNF703 ZNF703 TGFB1I1 TGFB1I1 JAG1 JAG1 TGFBR1 TGFBR1 ENG ENG EZH2 EZH2 LOXL2 LOXL2 IL6 IL6 ISL1 ISL1 SMAD3 SMAD3 DAB2 DAB2 BCL9L BCL9L ACVR1 ACVR1 TCF7L2 TCF7L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
OLFM1Olfactomedin 1. (636 aa)
BMP7Bone morphogenetic protein 7. (410 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (159 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (465 aa)
CTNNB1Catenin beta 1. (781 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1573 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ENSANAP00000028458C2H2-type domain-containing protein. (479 aa)
PDPNPodoplanin. (162 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FERMT2Fermitin family member 2. (706 aa)
ALX1ALX homeobox 1. (326 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
MDKUncharacterized protein. (144 aa)
CRB2Crumbs cell polarity complex component 2. (1291 aa)
AXIN2Axin 2. (843 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (417 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SDCBPSyndecan binding protein. (316 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSANAP00000022622PTN_MK_N domain-containing protein. (72 aa)
TBX20T-box transcription factor 20. (447 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
COL1A1Collagen type I alpha 1 chain. (1453 aa)
LOC105725023Uncharacterized protein. (336 aa)
GLIPR2SCP domain-containing protein; Belongs to the CRISP family. (156 aa)
FOXC1Forkhead box C1. (539 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NOTCH1Notch receptor 1. (2527 aa)
ZNF703Uncharacterized protein. (540 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (463 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
ENGEndoglin. (440 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
LOXL2Lysyl oxidase like 2. (869 aa)
IL6Interleukin 6. (213 aa)
ISL1Uncharacterized protein. (349 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DAB2DAB adaptor protein 2. (552 aa)
BCL9LBCL9 like. (1497 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TCF7L2Transcription factor 7 like 2. (618 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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