(78 nodes) Regulation of fatty acid metabolic process network (Aotus nancymaae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
	PDK1	Protein-serine/threonine kinase. (411 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	IRS1	Insulin receptor substrate 1. (1245 aa)
	MLXIPL	MLX interacting protein like. (852 aa)
	NCOR1	Nuclear receptor corepressor 1. (2439 aa)
	PLA2G3	Phospholipase A2 group III. (509 aa)
	CPT1A	Carnitine palmitoyltransferase 1A. (734 aa)
	MID1IP1	MID1 interacting protein 1. (183 aa)
	SCAP	Uncharacterized protein. (1241 aa)
	PDK3	Protein-serine/threonine kinase. (418 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1827 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	LOC105730799	CCDC144C domain-containing protein. (325 aa)
	FABP5	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (141 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (233 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1179 aa)
	ERLIN1	ER lipid raft associated 1. (348 aa)
	ERFE	Erythroferrone. (323 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (740 aa)
	ENSANAP00000009291	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (110 aa)
	IRS2	Insulin receptor substrate 2. (1369 aa)
	SOX9	SRY-box transcription factor 9. (505 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1323 aa)
	FABP3	Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	SLC45A3	Solute carrier family 45 member 3. (553 aa)
	TYSND1	Trypsin domain containing 1. (566 aa)
	ENSANAP00000012758	Lon N-terminal domain-containing protein. (278 aa)
	CD74	CD74 molecule. (280 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (692 aa)
	ERLIN2	ER lipid raft associated 2. (369 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (280 aa)
	SIRT4	Sirtuin 4. (255 aa)
	LONP2	Lon proteolytic domain-containing protein; Belongs to the peptidase S16 family. (160 aa)
	ENSANAP00000018891	Uncharacterized protein. (102 aa)
	APOC2	Proapolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. Belongs to the apolipoprotein C2 family. (101 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
	ENSANAP00000019702	Uncharacterized protein. (258 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	FABP1	Fatty acid binding protein 1. (127 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (459 aa)
	PDK2	Protein-serine/threonine kinase. (385 aa)
	ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase. (262 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (558 aa)
	ENSANAP00000022359	DUF3496 domain-containing protein. (143 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	PIBF1	Progesterone immunomodulatory binding factor 1. (757 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (283 aa)
	LPGAT1	Lysophosphatidylglycerol acyltransferase 1. (388 aa)
	SLC22A13	Solute carrier family 22 member 13. (551 aa)
	GIP	Gastric inhibitory polypeptide. (93 aa)
	TRIB3	Tribbles pseudokinase 3. (385 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	AVPR1A	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa)
	ENSANAP00000027785	Uncharacterized protein. (56 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (637 aa)
	MLYCD	Malonyl-CoA decarboxylase. (493 aa)
	DGAT2	Diacylglycerol O-acyltransferase 2. (388 aa)
	PDK4	Protein-serine/threonine kinase. (411 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (543 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (459 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	LOC105704748	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (541 aa)
	ABCD1	ATP binding cassette subfamily D member 1. (675 aa)
	PANK2	Pantothenate kinase 2. (547 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (802 aa)
	SIRT1	Sirtuin 1. (751 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2435 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (452 aa)
	ENSANAP00000037159	WD_REPEATS_REGION domain-containing protein. (508 aa)
	AVP	Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	ACACB	ENSANAP00000011232	ENSANAP00000036951	ATP binding cassette subfamily B member 11.	Acetyl-CoA carboxylase beta.	0.662
ABCB11	CPT1A	ENSANAP00000011232	ENSANAP00000002263	ATP binding cassette subfamily B member 11.	Carnitine palmitoyltransferase 1A.	0.500
ABCB11	CYP7A1	ENSANAP00000011232	ENSANAP00000003800	ATP binding cassette subfamily B member 11.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.617
ABCB11	LPGAT1	ENSANAP00000011232	ENSANAP00000024107	ATP binding cassette subfamily B member 11.	Lysophosphatidylglycerol acyltransferase 1.	0.424
ABCB11	MLYCD	ENSANAP00000011232	ENSANAP00000030838	ATP binding cassette subfamily B member 11.	Malonyl-CoA decarboxylase.	0.430
ABCD1	ABCD2	ENSANAP00000036118	ENSANAP00000009212	ATP binding cassette subfamily D member 1.	ATP binding cassette subfamily D member 2.	0.807
ABCD2	ABCD1	ENSANAP00000009212	ENSANAP00000036118	ATP binding cassette subfamily D member 2.	ATP binding cassette subfamily D member 1.	0.807
ACACB	ABCB11	ENSANAP00000036951	ENSANAP00000011232	Acetyl-CoA carboxylase beta.	ATP binding cassette subfamily B member 11.	0.662
ACACB	BRCA1	ENSANAP00000036951	ENSANAP00000004329	Acetyl-CoA carboxylase beta.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.851
ACACB	CPT1A	ENSANAP00000036951	ENSANAP00000002263	Acetyl-CoA carboxylase beta.	Carnitine palmitoyltransferase 1A.	0.949
ACACB	MLYCD	ENSANAP00000036951	ENSANAP00000030838	Acetyl-CoA carboxylase beta.	Malonyl-CoA decarboxylase.	0.933
ACACB	SREBF1	ENSANAP00000036951	ENSANAP00000007018	Acetyl-CoA carboxylase beta.	Sterol regulatory element binding transcription factor 1.	0.605
ACACB	TRIB3	ENSANAP00000036951	ENSANAP00000025092	Acetyl-CoA carboxylase beta.	Tribbles pseudokinase 3.	0.402
ADIPOQ	APPL2	ENSANAP00000019740	ENSANAP00000034448	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.575
ADIPOQ	IL1B	ENSANAP00000019740	ENSANAP00000000520	Adiponectin, C1Q and collagen domain containing.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.469
ADIPOQ	IRS1	ENSANAP00000019740	ENSANAP00000000658	Adiponectin, C1Q and collagen domain containing.	Insulin receptor substrate 1.	0.538
ADIPOQ	PLIN5	ENSANAP00000019740	ENSANAP00000021021	Adiponectin, C1Q and collagen domain containing.	Perilipin; Belongs to the perilipin family.	0.403
ADIPOQ	PPARA	ENSANAP00000019740	ENSANAP00000015794	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.547
ADIPOQ	PPARG	ENSANAP00000019740	ENSANAP00000004495	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.664
ADIPOQ	PPARGC1A	ENSANAP00000019740	ENSANAP00000036857	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.544