STRINGSTRING
RPS6KB1 RPS6KB1 FBXL2 FBXL2 SPHK1 SPHK1 SMAD2 SMAD2 PPP6R2 PPP6R2 IGBP1 IGBP1 FLT4 FLT4 LOC105707629 LOC105707629 FCRL6 FCRL6 PTPN1 PTPN1 MFHAS1 MFHAS1 ANKLE2 ANKLE2 SLC9A3R2 SLC9A3R2 CD22 CD22 PPP3R1 PPP3R1 MYO16 MYO16 ENSA ENSA SKAP2 SKAP2 LRRD1 LRRD1 ROS1 ROS1 BOD1L1 BOD1L1 AKAP11 AKAP11 STRN STRN FAM71F2 FAM71F2 LOC105719296 LOC105719296 ANAPC4 ANAPC4 ENSANAP00000022627 ENSANAP00000022627 MAGI2 MAGI2 ITGA1 ITGA1 SNX3 SNX3 SLC9A1 SLC9A1 GNA12 GNA12 TBK1 TBK1 LOC105707704 LOC105707704 ENSANAP00000021042 ENSANAP00000021042 ENSANAP00000020876 ENSANAP00000020876 CRY2 CRY2 SYTL2 SYTL2 SMG7 SMG7 STAT1 STAT1 CSF1R CSF1R FAM71F1 FAM71F1 DZIP3 DZIP3 ENSANAP00000019979 ENSANAP00000019979 FCRL3 FCRL3 SH2D4A SH2D4A IKBKE IKBKE PPP1R3F PPP1R3F PXN PXN CARHSP1 CARHSP1 STAT6 STAT6 PPP1R18 PPP1R18 ARPP19 ARPP19 PPP1R11 PPP1R11 AP3B2 AP3B2 WNK1 WNK1 KAT2A KAT2A FCRL2 FCRL2 SKAP1 SKAP1 TERF2IP TERF2IP GRIN3A GRIN3A RACK1 RACK1 CDH5 CDH5 PPP1R35 PPP1R35 YWHAE YWHAE MAST2 MAST2 STRN3 STRN3 KCNQ1 KCNQ1 SH2D4B SH2D4B PPP1R16A PPP1R16A KCNN4 KCNN4 MVP MVP PPARA PPARA BOD1 BOD1 ENSANAP00000015492 ENSANAP00000015492 IQGAP1 IQGAP1 DLG1 DLG1 SH3YL1 SH3YL1 EIF2AK3 EIF2AK3 MTMR9 MTMR9 MAPK1 MAPK1 ENSANAP00000014796 ENSANAP00000014796 CEP192 CEP192 STYXL1 STYXL1 ERBB2 ERBB2 PPP6R1 PPP6R1 ENSANAP00000014195 ENSANAP00000014195 CRY1 CRY1 PPP1R15A PPP1R15A CTTNBP2NL CTTNBP2NL HSP90B1 HSP90B1 PPP1CA PPP1CA ENSANAP00000011762 ENSANAP00000011762 CSRNP2 CSRNP2 TSC2 TSC2 RCAN3 RCAN3 ENSANAP00000010721 ENSANAP00000010721 IRS2 IRS2 FER FER FBXO41 FBXO41 CSK CSK SYK SYK HSF4 HSF4 MET MET JUP JUP TRAF3 TRAF3 CNST CNST PAWR PAWR PTPA PTPA PHACTR3 PHACTR3 DAB2IP DAB2IP TRPC4AP TRPC4AP MASTL MASTL PPP6R3 PPP6R3 GRB2 GRB2 LGALS3 LGALS3 SHOC2 SHOC2 LOC105729166 LOC105729166 MAPK8 MAPK8 MAPK10 MAPK10 SPTBN4 SPTBN4 SBF2 SBF2 KIFAP3 KIFAP3 SFI1 SFI1 JAK3 JAK3 PHACTR1 PHACTR1 PPP1CC PPP1CC CADM4 CADM4 DLG4 DLG4 ENSANAP00000000480 ENSANAP00000000480 SMTNL1 SMTNL1 SMAD3 SMAD3 PIK3R2 PIK3R2 TRAF2 TRAF2 PPP1R3C PPP1R3C NEK2 NEK2 LCK LCK CHCHD3 CHCHD3 NFATC2 NFATC2 SIGLEC11 SIGLEC11 PVRIG PVRIG ENSANAP00000036057 ENSANAP00000036057 GTF2F1 GTF2F1 LOC105719297 LOC105719297 ENSANAP00000036249 ENSANAP00000036249 AP3B1 AP3B1 PTK2 PTK2 CDKN1B CDKN1B PHACTR4 PHACTR4 EGFR EGFR STAT3 STAT3 PPP1R9B PPP1R9B FBXL20 FBXL20 PPP3CB PPP3CB SPRED1 SPRED1 CD33 CD33 LOC105724480 LOC105724480 STX17 STX17 SIRPA SIRPA JAK1 JAK1 VRK3 VRK3 PPP1R27 PPP1R27 PPP1R32 PPP1R32 DLG3 DLG3 ANK1 ANK1 PPP1R3E PPP1R3E ELL ELL AMBRA1 AMBRA1 SMTNL2 SMTNL2 TPRN TPRN ANAPC7 ANAPC7 MAP3K5 MAP3K5 PDLIM4 PDLIM4 MAPK3 MAPK3 ENSANAP00000040893 ENSANAP00000040893 LOC105705593 LOC105705593 CDC27 CDC27 SH3RF2 SH3RF2 MAPK14 MAPK14 SOD1 SOD1 ENSANAP00000042326 ENSANAP00000042326 ANAPC5 ANAPC5 ADCY8 ADCY8 PPME1 PPME1 MTMR4 MTMR4 SIRPD SIRPD PPP1R16B PPP1R16B PPP1R3A PPP1R3A PPP1R36 PPP1R36 C20orf27 C20orf27 ENSANAP00000032489 ENSANAP00000032489 CTNNB1 CTNNB1 VCP VCP ATP2B4 ATP2B4 PIK3R1 PIK3R1 MTMR3 MTMR3 SMG5 SMG5 BCL2 BCL2 LOC105721603 LOC105721603 STAU1 STAU1 STRN4 STRN4 BAD BAD ENSANAP00000028766 ENSANAP00000028766
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FBXL2F-box and leucine rich repeat protein 2. (423 aa)
SPHK1Sphingosine kinase 1. (469 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PPP6R2Uncharacterized protein. (965 aa)
IGBP1Uncharacterized protein. (339 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
LOC105707629Uncharacterized protein. (729 aa)
FCRL6Fc receptor like 6. (435 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
ANKLE2Ankyrin repeat and LEM domain containing 2. (933 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
CD22CD22 molecule. (728 aa)
PPP3R1Uncharacterized protein. (189 aa)
MYO16Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1814 aa)
ENSAUncharacterized protein. (132 aa)
SKAP2Src kinase associated phosphoprotein 2. (360 aa)
LRRD1Leucine rich repeats and death domain containing 1. (829 aa)
ROS1Tyrosine-protein kinase receptor. (2259 aa)
BOD1L1Biorientation of chromosomes in cell division 1 like 1. (3039 aa)
AKAP11A-kinase anchoring protein 11. (1899 aa)
STRNStriatin. (780 aa)
FAM71F2Family with sequence similarity 71 member F2. (308 aa)
LOC105719296Uncharacterized protein. (371 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
ENSANAP00000022627Uncharacterized protein. (294 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1090 aa)
SNX3Sorting nexin 3. (162 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
GNA12G protein subunit alpha 12. (380 aa)
TBK1TANK binding kinase 1. (690 aa)
LOC105707704Uncharacterized protein. (122 aa)
ENSANAP00000021042Uncharacterized protein. (136 aa)
ENSANAP00000020876Uncharacterized protein. (323 aa)
CRY2Cryptochrome circadian regulator 2. (587 aa)
SYTL2Uncharacterized protein. (2221 aa)
SMG7SMG7 nonsense mediated mRNA decay factor. (1215 aa)
STAT1Signal transducer and activator of transcription. (781 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (959 aa)
FAM71F1Family with sequence similarity 71 member F1. (282 aa)
DZIP3DAZ interacting zinc finger protein 3. (1198 aa)
ENSANAP00000019979Fork-head domain-containing protein. (535 aa)
FCRL3Fc receptor like 3. (712 aa)
SH2D4ASH2 domain containing 4A. (463 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (795 aa)
PXNUncharacterized protein. (1085 aa)
CARHSP1Calcium regulated heat stable protein 1. (147 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
PPP1R18Protein phosphatase 1 regulatory subunit 18. (633 aa)
ARPP19cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (130 aa)
PPP1R11Protein phosphatase 1 regulatory inhibitor subunit 11. (126 aa)
AP3B2AP-3 complex subunit beta. (1101 aa)
WNK1WNK lysine deficient protein kinase 1. (2831 aa)
KAT2ALysine acetyltransferase 2A. (844 aa)
FCRL2Fc receptor like 2. (459 aa)
SKAP1Src kinase associated phosphoprotein 1. (360 aa)
TERF2IPTERF2 interacting protein. (399 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35. (252 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1800 aa)
STRN3Striatin 3. (797 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
SH2D4BSH2 domain containing 4B. (214 aa)
PPP1R16AProtein phosphatase 1 regulatory subunit 16A. (528 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (427 aa)
MVPMajor vault protein. (896 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
BOD1Biorientation of chromosomes in cell division 1. (187 aa)
ENSANAP00000015492Uncharacterized protein. (175 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
SH3YL1SH3 and SYLF domain containing 1. (362 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (965 aa)
MTMR9Myotubularin related protein 9. (549 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
ENSANAP00000014796PX domain-containing protein. (143 aa)
CEP192Centrosomal protein 192. (2536 aa)
STYXL1Serine/threonine/tyrosine interacting like 1. (256 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PPP6R1Protein phosphatase 6 regulatory subunit 1. (883 aa)
ENSANAP00000014195Uncharacterized protein. (318 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (664 aa)
CTTNBP2NLCTTNBP2 N-terminal like. (624 aa)
HSP90B1HATPase_c domain-containing protein. (818 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ENSANAP00000011762Uncharacterized protein. (113 aa)
CSRNP2Cysteine and serine rich nuclear protein 2. (543 aa)
TSC2TSC complex subunit 2. (1807 aa)
RCAN3RCAN family member 3. (241 aa)
ENSANAP00000010721Serine/threonine-protein phosphatase. (280 aa)
IRS2Insulin receptor substrate 2. (1369 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
FBXO41F-box protein 41. (875 aa)
CSKTyrosine-protein kinase. (450 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
HSF4Heat shock transcription factor 4. (492 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1391 aa)
JUPUncharacterized protein. (745 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa)
CNSTConsortin, connexin sorting protein. (724 aa)
PAWRPro-apoptotic WT1 regulator. (340 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (380 aa)
PHACTR3Phosphatase and actin regulator. (565 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (797 aa)
MASTLMicrotubule associated serine/threonine kinase like. (878 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LGALS3Galectin. (275 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (586 aa)
LOC105729166Uncharacterized protein. (734 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
MAPK10Mitogen-activated protein kinase. (533 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2562 aa)
SBF2SET binding factor 2. (1804 aa)
KIFAP3Kinesin associated protein 3. (800 aa)
SFI1SFI1 centrin binding protein. (1234 aa)
JAK3Tyrosine-protein kinase. (1119 aa)
PHACTR1Phosphatase and actin regulator. (607 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CADM4Cell adhesion molecule 4. (389 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (804 aa)
ENSANAP00000000480Uncharacterized protein. (306 aa)
SMTNL1Smoothelin like 1. (496 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PIK3R2Uncharacterized protein. (640 aa)
TRAF2TNF receptor-associated factor. (493 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
NEK2NIMA related kinase 2. (444 aa)
LCKTyrosine-protein kinase Lck; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein [...] (541 aa)
CHCHD3MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (233 aa)
NFATC2Nuclear factor of activated T cells 2. (923 aa)
SIGLEC11Uncharacterized protein. (754 aa)
PVRIGPVR related immunoglobulin domain containing. (324 aa)
ENSANAP00000036057Uncharacterized protein. (341 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
LOC105719297Uncharacterized protein. (485 aa)
ENSANAP00000036249Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (310 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1077 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (205 aa)
PHACTR4Phosphatase and actin regulator. (671 aa)
EGFREpidermal growth factor receptor. (705 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (783 aa)
FBXL20F-box and leucine rich repeat protein 20. (438 aa)
PPP3CBSerine/threonine-protein phosphatase. (439 aa)
SPRED1Sprouty related EVH1 domain containing 1. (447 aa)
CD33CD33 molecule. (375 aa)
LOC105724480Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (416 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
SIRPAUncharacterized protein. (473 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
VRK3VRK serine/threonine kinase 3. (424 aa)
PPP1R27Protein phosphatase 1 regulatory subunit 27. (160 aa)
PPP1R32Protein phosphatase 1 regulatory subunit 32. (425 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (853 aa)
ANK1Ankyrin 1. (1892 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (230 aa)
ELLElongation factor for RNA polymerase II. (621 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1289 aa)
SMTNL2Smoothelin like 2. (434 aa)
TPRNTaperin. (666 aa)
ANAPC7Anaphase promoting complex subunit 7. (565 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
PDLIM4PDZ and LIM domain 4. (330 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSANAP00000040893MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (224 aa)
LOC105705593Uncharacterized protein. (302 aa)
CDC27Cell division cycle 27. (831 aa)
SH3RF2SH3 domain containing ring finger 2. (729 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
ENSANAP00000042326WD_REPEATS_REGION domain-containing protein. (307 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PPME1Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (321 aa)
MTMR4Myotubularin related protein 4. (1193 aa)
SIRPDSignal regulatory protein delta. (172 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (567 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1118 aa)
PPP1R36Protein phosphatase 1 regulatory subunit 36. (399 aa)
C20orf27Chromosome 20 open reading frame 27. (189 aa)
ENSANAP00000032489SER_THR_PHOSPHATASE domain-containing protein. (262 aa)
CTNNB1Catenin beta 1. (781 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (815 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1025 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
MTMR3Myotubularin related protein 3. (1218 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1016 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
LOC105721603Uncharacterized protein. (891 aa)
STAU1Staufen double-stranded RNA binding protein 1. (583 aa)
STRN4Striatin 4. (634 aa)
BADBCL2 associated agonist of cell death. (167 aa)
ENSANAP00000028766Uncharacterized protein. (619 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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