(56 nodes) Cholesterol transport network (Aotus nancymaae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (281 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1590 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	SCP2	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
	ARL8A	ADP ribosylation factor like GTPase 8A; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (380 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (651 aa)
	CLU	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
	SERAC1	Serine active site containing 1. (654 aa)
	APOA2	Apolipoprotein A2. (132 aa)
	OSBP	Oxysterol-binding protein; Belongs to the OSBP family. (807 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (203 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2602 aa)
	ARV1	ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
	MSR1	Macrophage scavenger receptor 1. (451 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)
	LDLR	Low density lipoprotein receptor. (786 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	SOAT1	O-acyltransferase. (519 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (381 aa)
	APOB	Apolipoprotein B. (3824 aa)
	LIPC	Lipase C, hepatic type. (499 aa)
	LOC105714098	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (537 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (640 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2220 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2437 aa)
	LIMA1	LIM domain and actin binding 1. (760 aa)
	STX12	Syntaxin 12; Belongs to the syntaxin family. (276 aa)
	OSBPL2	Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
	STARD4	StAR related lipid transfer domain containing 4. (205 aa)
	ABCA8	ATP binding cassette subfamily A member 8. (1621 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (473 aa)
	SYT7	Synaptotagmin 7. (686 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (551 aa)
	HNF1A	HNF1 homeobox A. (636 aa)
	LIPG	Lipase G, endothelial type. (500 aa)
	ARL8B	ADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (244 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2146 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (442 aa)
	TPCN2	Two pore segment channel 2. (752 aa)
	VPS4A	Uncharacterized protein; Belongs to the AAA ATPase family. (492 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	CETP	Cholesteryl ester transfer protein. (521 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)
	SOAT2	O-acyltransferase. (526 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (603 aa)
	STARD3	StAR related lipid transfer domain containing 3. (476 aa)
	STARD3NL	MENTAL domain-containing protein. (172 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (881 aa)
	CEL	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (628 aa)
	ENSANAP00000018437	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (454 aa)
	STARD5	StAR related lipid transfer domain containing 5. (205 aa)
	TSPO2	Translocator protein 2. (170 aa)
	ENSANAP00000018748	MENTAL domain-containing protein. (190 aa)
	APOC2	Proapolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. Belongs to the apolipoprotein C2 family. (101 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOA2	ENSANAP00000031638	ENSANAP00000028816	ATP binding cassette subfamily A member 1.	Apolipoprotein A2.	0.501
ABCA1	APOA5	ENSANAP00000031638	ENSANAP00000025609	ATP binding cassette subfamily A member 1.	Apolipoprotein A5.	0.405
ABCA1	APOB	ENSANAP00000031638	ENSANAP00000028934	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.614
ABCA1	APOE	ENSANAP00000031638	ENSANAP00000021488	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.764
ABCA1	CD36	ENSANAP00000031638	ENSANAP00000002791	ATP binding cassette subfamily A member 1.	CD36 molecule; Belongs to the CD36 family.	0.538
ABCA1	CETP	ENSANAP00000031638	ENSANAP00000011865	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein.	0.657
ABCA1	LCAT	ENSANAP00000031638	ENSANAP00000007340	ATP binding cassette subfamily A member 1.	Lecithin-cholesterol acyltransferase.	0.572
ABCA1	LIPG	ENSANAP00000031638	ENSANAP00000005449	ATP binding cassette subfamily A member 1.	Lipase G, endothelial type.	0.510
ABCA1	NPC1	ENSANAP00000031638	ENSANAP00000012524	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 1.	0.574
ABCA1	SCARB1	ENSANAP00000031638	ENSANAP00000034344	ATP binding cassette subfamily A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.539
ABCA7	APOE	ENSANAP00000006596	ENSANAP00000021488	ATP binding cassette subfamily A member 7.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.493
ABCA7	CLU	ENSANAP00000006596	ENSANAP00000028368	ATP binding cassette subfamily A member 7.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.579
ABCG1	ABCG5	ENSANAP00000015403	ENSANAP00000026378	ATP binding cassette subfamily G member 1.	ATP binding cassette subfamily G member 5.	0.903
ABCG1	APOB	ENSANAP00000015403	ENSANAP00000028934	ATP binding cassette subfamily G member 1.	Apolipoprotein B.	0.575
ABCG1	APOE	ENSANAP00000015403	ENSANAP00000021488	ATP binding cassette subfamily G member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.748
ABCG1	CETP	ENSANAP00000015403	ENSANAP00000011865	ATP binding cassette subfamily G member 1.	Cholesteryl ester transfer protein.	0.579
ABCG1	LCAT	ENSANAP00000015403	ENSANAP00000007340	ATP binding cassette subfamily G member 1.	Lecithin-cholesterol acyltransferase.	0.615
ABCG1	LIPG	ENSANAP00000015403	ENSANAP00000005449	ATP binding cassette subfamily G member 1.	Lipase G, endothelial type.	0.433
ABCG1	NPC1	ENSANAP00000015403	ENSANAP00000012524	ATP binding cassette subfamily G member 1.	NPC intracellular cholesterol transporter 1.	0.606
ABCG1	SCARB1	ENSANAP00000015403	ENSANAP00000034344	ATP binding cassette subfamily G member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.495