STRINGSTRING
SMAD3 SMAD3 LOC105709188 LOC105709188 NOG NOG TGFBR3 TGFBR3 DDX5 DDX5 SCX SCX SMAD9 SMAD9 ZNF831 ZNF831 FKBP8 FKBP8 SMAD6 SMAD6 NOTCH2 NOTCH2 SFRP2 SFRP2 CHRDL1 CHRDL1 SFRP1 SFRP1 EXT1 EXT1 BMPR1A BMPR1A COMP COMP SOSTDC1 SOSTDC1 EGR1 EGR1 ENG ENG BMPR1B BMPR1B CHRD CHRD NODAL NODAL GDF3 GDF3 DLX5 DLX5 ENSANAP00000013693 ENSANAP00000013693 ETV2 ETV2 RGMB RGMB SMAD4 SMAD4 FAM83G FAM83G HJV HJV BMP5 BMP5 BMP8B BMP8B TMPRSS6 TMPRSS6 ACVRL1 ACVRL1 HFE HFE GDF5 GDF5 FST FST SMAD7 SMAD7 ZNF8 ZNF8 USP15 USP15 BMP15 BMP15 MEGF8 MEGF8 BMP10 BMP10 TGFB3 TGFB3 GDF6 GDF6 ENSANAP00000023537 ENSANAP00000023537 BMPR2 BMPR2 DSG4 DSG4 TWSG1 TWSG1 ABL1 ABL1 LEFTY2 LEFTY2 WNT5A WNT5A ACVR2A ACVR2A GDF2 GDF2 LEF1 LEF1 BMPER BMPER PDCD4 PDCD4 SPART SPART SMURF1 SMURF1 TGFB2 TGFB2 CCDC142 CCDC142 RGMA RGMA DLX3 DLX3 RUNX2 RUNX2 LOC105708014 LOC105708014 ACVR2B ACVR2B BMP6 BMP6 BMP2 BMP2 GDF7 GDF7 TGFB1 TGFB1 SMAD1 SMAD1 BMP4 BMP4 MSX1 MSX1 SLC33A1 SLC33A1 SMAD5 SMAD5 BMP7 BMP7 USP9X USP9X ACVR1 ACVR1 ATF2 ATF2 SMPD3 SMPD3 SLC39A5 SLC39A5 HIVEP1 HIVEP1 MAPK3 MAPK3 SOST SOST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC105709188Uncharacterized protein. (421 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (661 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
ZNF831Zinc finger protein 831. (1662 aa)
FKBP8Peptidylprolyl isomerase. (444 aa)
SMAD6Mothers against decapentaplegic homolog. (494 aa)
NOTCH2Notch receptor 2. (2471 aa)
SFRP2Secreted frizzled related protein 2. (296 aa)
CHRDL1Chordin like 1. (452 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (546 aa)
ENGEndoglin. (440 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (944 aa)
NODALNodal growth differentiation factor. (347 aa)
GDF3Growth differentiation factor 3. (364 aa)
DLX5Distal-less homeobox 5. (289 aa)
ENSANAP00000013693Uncharacterized protein. (110 aa)
ETV2ETS variant 2. (370 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (476 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FAM83GFamily with sequence similarity 83 member G. (674 aa)
HJVUncharacterized protein. (383 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMP8BTGF_BETA_2 domain-containing protein. (395 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (822 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
GDF5Growth differentiation factor 5. (501 aa)
FSTFollistatin. (344 aa)
SMAD7Mothers against decapentaplegic homolog. (489 aa)
ZNF8Zinc finger protein 8. (575 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
MEGF8Multiple EGF like domains 8. (2858 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GDF6Growth differentiation factor 6. (454 aa)
ENSANAP00000023537TGFb_propeptide domain-containing protein. (318 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1037 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
LEFTY2TGF_BETA_2 domain-containing protein. (347 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
GDF2Growth differentiation factor 2. (429 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
BMPERBMP binding endothelial regulator. (685 aa)
PDCD4Programmed cell death 4. (469 aa)
SPARTSpartin. (664 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CCDC142Coiled-coil domain containing 142. (745 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (453 aa)
DLX3Distal-less homeobox 3. (287 aa)
RUNX2RUNX family transcription factor 2. (587 aa)
LOC105708014TGF_BETA_2 domain-containing protein. (367 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
BMP6Bone morphogenetic protein 6. (508 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GDF7Growth differentiation factor 7. (421 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MSX1Msh homeobox 1. (303 aa)
SLC33A1Solute carrier family 33 member 1. (550 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
BMP7Bone morphogenetic protein 7. (410 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2576 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ATF2Activating transcription factor 2. (287 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
SLC39A5Solute carrier family 39 member 5. (539 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2721 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
SOSTSclerostin. (213 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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