(51 nodes) Negative regulation of BMP signaling pathway network (Aotus nancymaae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHRDL2	Chordin like 2. (430 aa)
	FSTL3	Follistatin like 3. (263 aa)
	SOST	Sclerostin. (213 aa)
	NBL1	NBL1, DAN family BMP antagonist. (216 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	SMURF2	E3 ubiquitin-protein ligase. (736 aa)
	SMURF1	E3 ubiquitin-protein ligase. (757 aa)
	SPART	Spartin. (664 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (454 aa)
	SORL1	Sortilin related receptor 1. (2213 aa)
	BMPER	BMP binding endothelial regulator. (685 aa)
	UBE2D1	Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	SKOR2	SKI family transcriptional corepressor 2. (960 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	TRIM33	Tripartite motif containing 33. (1113 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	HTRA3	HtrA serine peptidase 3. (452 aa)
	CTDSPL2	CTD small phosphatase like 2. (466 aa)
	CER1	Cerberus 1, DAN family BMP antagonist. (267 aa)
	SMAD7	Mothers against decapentaplegic homolog. (489 aa)
	TMPRSS6	Transmembrane serine protease 6; Belongs to the peptidase S1 family. (822 aa)
	SKOR1	SKI family transcriptional corepressor 1. (957 aa)
	HJV	Uncharacterized protein. (383 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	NOTCH1	Notch receptor 1. (2527 aa)
	CRIM1	Cysteine rich transmembrane BMP regulator 1. (1037 aa)
	LOC105730229	PPM-type phosphatase domain-containing protein. (310 aa)
	TNFAIP6	TNF alpha induced protein 6. (277 aa)
	GDF3	Growth differentiation factor 3. (364 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (944 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	VWC2	Von Willebrand factor C domain containing 2. (325 aa)
	SOSTDC1	Sclerostin domain containing 1. (230 aa)
	HTRA1	HtrA serine peptidase 1. (462 aa)
	VWC2L	Von Willebrand factor C domain containing 2 like. (222 aa)
	DAND5	DAN domain BMP antagonist family member 5. (189 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	CHRDL1	Chordin like 1. (452 aa)
	LEMD2	LEM domain containing 2. (503 aa)
	SKI	SKI proto-oncogene. (726 aa)
	SFRP2	Secreted frizzled related protein 2. (296 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
	SMAD6	Mothers against decapentaplegic homolog. (494 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1203 aa)
	LEMD3	LEM domain containing 3. (911 aa)
	GREM2	Gremlin. (168 aa)
	RBPMS2	RNA binding protein, mRNA processing factor 2. (205 aa)
	FBN1	Fibrillin 1. (2872 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	LOC105709188	Uncharacterized protein. (421 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	SMURF2	ENSANAP00000024509	ENSANAP00000033856	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase.	0.424
BAMBI	CHRD	ENSANAP00000036116	ENSANAP00000011797	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.493
BAMBI	SMAD6	ENSANAP00000036116	ENSANAP00000005203	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.724
BAMBI	SMAD7	ENSANAP00000036116	ENSANAP00000020600	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.885
BMPER	CHRD	ENSANAP00000027209	ENSANAP00000011797	BMP binding endothelial regulator.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.576
BMPER	TWSG1	ENSANAP00000027209	ENSANAP00000023993	BMP binding endothelial regulator.	Twisted gastrulation BMP signaling modulator 1.	0.518
CHRD	BAMBI	ENSANAP00000011797	ENSANAP00000036116	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.493
CHRD	BMPER	ENSANAP00000011797	ENSANAP00000027209	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	BMP binding endothelial regulator.	0.576
CHRD	GDF3	ENSANAP00000011797	ENSANAP00000012077	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Growth differentiation factor 3.	0.574
CHRD	GREM2	ENSANAP00000011797	ENSANAP00000003263	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Gremlin.	0.431
CHRD	NOG	ENSANAP00000011797	ENSANAP00000000648	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.520
CHRD	SMAD6	ENSANAP00000011797	ENSANAP00000005203	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Mothers against decapentaplegic homolog.	0.518
CHRD	SMAD7	ENSANAP00000011797	ENSANAP00000020600	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Mothers against decapentaplegic homolog.	0.413
CHRD	TNFAIP6	ENSANAP00000011797	ENSANAP00000012295	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	TNF alpha induced protein 6.	0.722
CHRD	TWSG1	ENSANAP00000011797	ENSANAP00000023993	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Twisted gastrulation BMP signaling modulator 1.	0.702
CHRD	VWC2	ENSANAP00000011797	ENSANAP00000011417	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Von Willebrand factor C domain containing 2.	0.432
CHRDL2	TWSG1	ENSANAP00000015994	ENSANAP00000023993	Chordin like 2.	Twisted gastrulation BMP signaling modulator 1.	0.426
DKK1	NOG	ENSANAP00000005396	ENSANAP00000000648	Dickkopf WNT signaling pathway inhibitor 1.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.538
DKK1	SFRP1	ENSANAP00000005396	ENSANAP00000007291	Dickkopf WNT signaling pathway inhibitor 1.	Secreted frizzled related protein 1.	0.587
DKK1	SFRP2	ENSANAP00000005396	ENSANAP00000006147	Dickkopf WNT signaling pathway inhibitor 1.	Secreted frizzled related protein 2.	0.533