(57 nodes) Golgi-associated vesicle membrane network (Aotus nancymaae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Your Input:
	COPA	Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1231 aa)
	ZDHHC13	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (622 aa)
	ENSANAP00000005848	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
	KDELR2	ER lumen protein-retaining receptor. (347 aa)
	SPPL2A	Signal peptide peptidase like 2A. (565 aa)
	AP1M1	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (469 aa)
	COPG2	Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (871 aa)
	CNGA2	Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
	COPE	Coatomer protein complex subunit epsilon. (332 aa)
	AP1B1	AP complex subunit beta. (769 aa)
	COPB2	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (906 aa)
	AP1G1	AP-1 complex subunit gamma. (830 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (587 aa)
	DIPK2A	Divergent protein kinase domain 2A. (430 aa)
	ENSANAP00000039142	Clat_adaptor_s domain-containing protein. (66 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (177 aa)
	SPPL2B	Signal peptide peptidase like 2B. (592 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	NRGN	Neurogranin. (78 aa)
	SYNRG	Synergin gamma. (1253 aa)
	AP1G2	AP-1 complex subunit gamma. (785 aa)
	ARCN1	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (550 aa)
	AFTPH	Aftiphilin. (935 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1503 aa)
	COPZ1	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (197 aa)
	CLBA1	Clathrin binding box of aftiphilin containing 1. (325 aa)
	SLC18A3	Solute carrier family 18 member A3. (532 aa)
	ZDHHC17	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (632 aa)
	RASSF9	Ras association domain family member 9. (435 aa)
	SCYL1	SCY1 like pseudokinase 1. (808 aa)
	ITM2B	Integral membrane protein 2B. (266 aa)
	CSPG5	Chondroitin sulfate proteoglycan 5. (563 aa)
	RHOQ	Ras homolog family member Q. (205 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	TMED7	Transmembrane p24 trafficking protein 7. (224 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2102 aa)
	AP1S2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
	CNGB1	Cyclic nucleotide gated channel subunit beta 1. (1216 aa)
	TMEM199	Transmembrane protein 199. (208 aa)
	CNGA4	Cyclic nucleotide gated channel subunit alpha 4. (570 aa)
	ENSANAP00000013734	Uncharacterized protein. (502 aa)
	AP1M2	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (385 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4274 aa)
	KDELR3	ER lumen protein-retaining receptor. (228 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
	NCALD	Neurocalcin delta. (193 aa)
	LOC105710091	Uncharacterized protein. (738 aa)
	COPB1	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (953 aa)
	TMED3	Transmembrane p24 trafficking protein 3. (231 aa)
	SPPL3	Signal peptide peptidase like 3. (384 aa)
	TSGA13	Testis specific 13. (275 aa)
	COPZ2	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (210 aa)
	KDELR1	ER lumen protein-retaining receptor. (212 aa)
	ENSANAP00000012036	Adaptin_N domain-containing protein. (130 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFTPH	AP1B1	ENSANAP00000030857	ENSANAP00000002345	Aftiphilin.	AP complex subunit beta.	0.420
AFTPH	AP1G1	ENSANAP00000030857	ENSANAP00000041879	Aftiphilin.	AP-1 complex subunit gamma.	0.476
AFTPH	AP1G2	ENSANAP00000030857	ENSANAP00000031284	Aftiphilin.	AP-1 complex subunit gamma.	0.509
AFTPH	AP1M1	ENSANAP00000030857	ENSANAP00000004197	Aftiphilin.	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.664
AFTPH	AP1M2	ENSANAP00000030857	ENSANAP00000013532	Aftiphilin.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.664
AFTPH	AP1S1	ENSANAP00000030857	ENSANAP00000039098	Aftiphilin.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.558
AFTPH	AP1S2	ENSANAP00000030857	ENSANAP00000016320	Aftiphilin.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.804
AFTPH	AP1S3	ENSANAP00000030857	ENSANAP00000035449	Aftiphilin.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.603
AFTPH	CLTC	ENSANAP00000030857	ENSANAP00000040701	Aftiphilin.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.418
AFTPH	CLTCL1	ENSANAP00000030857	ENSANAP00000028648	Aftiphilin.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.413
AFTPH	ENSANAP00000005848	ENSANAP00000030857	ENSANAP00000005848	Aftiphilin.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.664
AFTPH	ENSANAP00000039142	ENSANAP00000030857	ENSANAP00000039142	Aftiphilin.	Clat_adaptor_s domain-containing protein.	0.400
AFTPH	SYNRG	ENSANAP00000030857	ENSANAP00000031657	Aftiphilin.	Synergin gamma.	0.660
AP1B1	AFTPH	ENSANAP00000002345	ENSANAP00000030857	AP complex subunit beta.	Aftiphilin.	0.420
AP1B1	AP1G1	ENSANAP00000002345	ENSANAP00000041879	AP complex subunit beta.	AP-1 complex subunit gamma.	0.995
AP1B1	AP1G2	ENSANAP00000002345	ENSANAP00000031284	AP complex subunit beta.	AP-1 complex subunit gamma.	0.985
AP1B1	AP1M1	ENSANAP00000002345	ENSANAP00000004197	AP complex subunit beta.	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.977
AP1B1	AP1M2	ENSANAP00000002345	ENSANAP00000013532	AP complex subunit beta.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.977
AP1B1	AP1S1	ENSANAP00000002345	ENSANAP00000039098	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.993
AP1B1	AP1S2	ENSANAP00000002345	ENSANAP00000016320	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.982