55 items (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LAG3	Lymphocyte activating 3. (525 aa)
	CD28	CD28 molecule. (220 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1006 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (259 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	CLEC7A	C-type lectin domain containing 7A. (252 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	BTNL2	Butyrophilin like 2. (482 aa)
	ENSANAP00000009102	KH type-2 domain-containing protein. (208 aa)
	EZR	Ezrin. (619 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2364 aa)
	GLMN	Glomulin, FKBP associated protein. (539 aa)
	CD34	CD34 molecule. (388 aa)
	HOMER3	WH1 domain-containing protein. (300 aa)
	PTPRC	Uncharacterized protein. (1299 aa)
	ENSANAP00000003886	KH type-2 domain-containing protein. (102 aa)
	CARD9	Caspase recruitment domain family member 9. (580 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	ANXA1	Annexin. (346 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (462 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (277 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (486 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	PRNP	Major prion protein; Belongs to the prion family. (229 aa)
	PRKD2	Protein kinase D2. (755 aa)
	GATA3	GATA binding protein 3. (409 aa)
	ENSANAP00000028020	Uncharacterized protein; Belongs to the universal ribosomal protein uS3 family. (207 aa)
	CD83	CD83 molecule. (201 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	PDE4D	Phosphodiesterase. (748 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	LOC105729229	WH1 domain-containing protein. (343 aa)
	STOML2	Stomatin like 2. (356 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (282 aa)
	ZFP36	ZFP36 ring finger protein. (332 aa)
	TRAF2	TNF receptor-associated factor. (493 aa)
	CD80	CD80 molecule. (289 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	VSIG4	V-set and immunoglobulin domain containing 4. (391 aa)
	MALT1	MALT1 paracaspase. (819 aa)
	FOXP3	Forkhead box P3. (456 aa)
	STAT5B	Signal transducer and activator of transcription. (768 aa)
	NAV3	Neuron navigator 3. (2363 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	CD3E	CD3e molecule. (199 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	HOMER2	Homer scaffold protein 2. (354 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (311 aa)
	CD86	CD86 molecule. (331 aa)
	ENSANAP00000010942	Ribosomal_S3_C domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (225 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CD34	ENSANAP00000024509	ENSANAP00000005723	Tyrosine-protein kinase.	CD34 molecule.	0.401
ABL1	RUNX1	ENSANAP00000024509	ENSANAP00000024288	Tyrosine-protein kinase.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.671
ABL1	STAT5B	ENSANAP00000024509	ENSANAP00000039962	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.938
ANXA1	IL1B	ENSANAP00000024111	ENSANAP00000000520	Annexin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.404
CARD11	CARD9	ENSANAP00000029812	ENSANAP00000003113	Caspase recruitment domain family member 11.	Caspase recruitment domain family member 9.	0.589
CARD11	CD28	ENSANAP00000029812	ENSANAP00000019444	Caspase recruitment domain family member 11.	CD28 molecule.	0.497
CARD11	MALT1	ENSANAP00000029812	ENSANAP00000037697	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.993
CARD11	MAP3K7	ENSANAP00000029812	ENSANAP00000018427	Caspase recruitment domain family member 11.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.782
CARD11	PRKCQ	ENSANAP00000029812	ENSANAP00000025479	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.987
CARD11	RIPK2	ENSANAP00000029812	ENSANAP00000025668	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.537
CARD11	TNFAIP3	ENSANAP00000029812	ENSANAP00000023338	Caspase recruitment domain family member 11.	TNF alpha induced protein 3.	0.461
CARD11	TRAF6	ENSANAP00000029812	ENSANAP00000020369	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.788
CARD9	CARD11	ENSANAP00000003113	ENSANAP00000029812	Caspase recruitment domain family member 9.	Caspase recruitment domain family member 11.	0.589
CARD9	CLEC7A	ENSANAP00000003113	ENSANAP00000021011	Caspase recruitment domain family member 9.	C-type lectin domain containing 7A.	0.560
CARD9	MALT1	ENSANAP00000003113	ENSANAP00000037697	Caspase recruitment domain family member 9.	MALT1 paracaspase.	0.960
CARD9	PRKCQ	ENSANAP00000003113	ENSANAP00000025479	Caspase recruitment domain family member 9.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.646
CARD9	RIPK2	ENSANAP00000003113	ENSANAP00000025668	Caspase recruitment domain family member 9.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.936
CARD9	TRAF6	ENSANAP00000003113	ENSANAP00000020369	Caspase recruitment domain family member 9.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.405
CD28	CARD11	ENSANAP00000019444	ENSANAP00000029812	CD28 molecule.	Caspase recruitment domain family member 11.	0.497
CD28	CD3E	ENSANAP00000019444	ENSANAP00000017753	CD28 molecule.	CD3e molecule.	0.449