(20 nodes) Nuclear DNA replication network (Aotus nancymaae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BLM	BLM RecQ like helicase. (1415 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (904 aa)
	GINS1	GINS complex subunit 1. (174 aa)
	UPF1	UPF1 RNA helicase and ATPase. (1092 aa)
	BRCA2	BRCA2 DNA repair associated. (3404 aa)
	ENSANAP00000015418	CDT1 domain-containing protein. (517 aa)
	LIG1	DNA ligase. (881 aa)
	MCM6	DNA helicase; Belongs to the MCM family. (797 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (866 aa)
	RTF2	Replication termination factor 2. (306 aa)
	CDT1	CDT1 domain-containing protein. (547 aa)
	POLA1	DNA polymerase. (1475 aa)
	DONSON	Downstream neighbor of SON. (562 aa)
	WRN	WRN RecQ like helicase. (1386 aa)
	CDC45	Cell division cycle 45. (594 aa)
	GMNN	Geminin DNA replication inhibitor. (209 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	DNA2	DNA replication helicase/nuclease 2. (936 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	ATAD5	ATPase family AAA domain containing 5. (1835 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	BLM	ENSANAP00000042030	ENSANAP00000042251	ATPase family AAA domain containing 5.	BLM RecQ like helicase.	0.957
ATAD5	BRCA2	ENSANAP00000042030	ENSANAP00000015411	ATPase family AAA domain containing 5.	BRCA2 DNA repair associated.	0.788
ATAD5	CDC45	ENSANAP00000042030	ENSANAP00000034009	ATPase family AAA domain containing 5.	Cell division cycle 45.	0.892
ATAD5	CDT1	ENSANAP00000042030	ENSANAP00000021909	ATPase family AAA domain containing 5.	CDT1 domain-containing protein.	0.815
ATAD5	DNA2	ENSANAP00000042030	ENSANAP00000040319	ATPase family AAA domain containing 5.	DNA replication helicase/nuclease 2.	0.928
ATAD5	DONSON	ENSANAP00000042030	ENSANAP00000029856	ATPase family AAA domain containing 5.	Downstream neighbor of SON.	0.526
ATAD5	ENSANAP00000015418	ENSANAP00000042030	ENSANAP00000015418	ATPase family AAA domain containing 5.	CDT1 domain-containing protein.	0.815
ATAD5	LIG1	ENSANAP00000042030	ENSANAP00000015982	ATPase family AAA domain containing 5.	DNA ligase.	0.845
ATAD5	MCM2	ENSANAP00000042030	ENSANAP00000002342	ATPase family AAA domain containing 5.	DNA helicase; Belongs to the MCM family.	0.881
ATAD5	MCM4	ENSANAP00000042030	ENSANAP00000017109	ATPase family AAA domain containing 5.	DNA helicase; Belongs to the MCM family.	0.835
ATAD5	MCM6	ENSANAP00000042030	ENSANAP00000016825	ATPase family AAA domain containing 5.	DNA helicase; Belongs to the MCM family.	0.782
ATAD5	PCNA	ENSANAP00000042030	ENSANAP00000040255	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.974
ATAD5	POLA1	ENSANAP00000042030	ENSANAP00000027767	ATPase family AAA domain containing 5.	DNA polymerase.	0.876
ATAD5	RAD51	ENSANAP00000042030	ENSANAP00000041855	ATPase family AAA domain containing 5.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.942
ATAD5	UPF1	ENSANAP00000042030	ENSANAP00000012377	ATPase family AAA domain containing 5.	UPF1 RNA helicase and ATPase.	0.497
ATAD5	WRN	ENSANAP00000042030	ENSANAP00000030110	ATPase family AAA domain containing 5.	WRN RecQ like helicase.	0.989
BLM	ATAD5	ENSANAP00000042251	ENSANAP00000042030	BLM RecQ like helicase.	ATPase family AAA domain containing 5.	0.957
BLM	BRCA2	ENSANAP00000042251	ENSANAP00000015411	BLM RecQ like helicase.	BRCA2 DNA repair associated.	0.844
BLM	CDC45	ENSANAP00000042251	ENSANAP00000034009	BLM RecQ like helicase.	Cell division cycle 45.	0.631
BLM	CDT1	ENSANAP00000042251	ENSANAP00000021909	BLM RecQ like helicase.	CDT1 domain-containing protein.	0.421