(21 nodes) Cholesterol efflux network (Aotus nancymaae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ABCA8	ATP binding cassette subfamily A member 8. (1621 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2146 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)
	SOAT2	O-acyltransferase. (526 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (603 aa)
	APOC2	Proapolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. Belongs to the apolipoprotein C2 family. (101 aa)
	SOAT1	O-acyltransferase. (519 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (281 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (381 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1590 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (651 aa)
	APOB	Apolipoprotein B. (3824 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2602 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (640 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2220 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2437 aa)
	STX12	Syntaxin 12; Belongs to the syntaxin family. (276 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (203 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (551 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOA5	ENSANAP00000031638	ENSANAP00000025609	ATP binding cassette subfamily A member 1.	Apolipoprotein A5.	0.405
ABCA1	APOB	ENSANAP00000031638	ENSANAP00000028934	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.614
ABCA1	APOE	ENSANAP00000031638	ENSANAP00000021488	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.764
ABCA1	NPC1	ENSANAP00000031638	ENSANAP00000012524	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 1.	0.574
ABCA1	SCARB1	ENSANAP00000031638	ENSANAP00000034344	ATP binding cassette subfamily A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.539
ABCA7	APOE	ENSANAP00000006596	ENSANAP00000021488	ATP binding cassette subfamily A member 7.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.493
ABCG1	ABCG5	ENSANAP00000015403	ENSANAP00000026378	ATP binding cassette subfamily G member 1.	ATP binding cassette subfamily G member 5.	0.903
ABCG1	APOB	ENSANAP00000015403	ENSANAP00000028934	ATP binding cassette subfamily G member 1.	Apolipoprotein B.	0.575
ABCG1	APOE	ENSANAP00000015403	ENSANAP00000021488	ATP binding cassette subfamily G member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.748
ABCG1	NPC1	ENSANAP00000015403	ENSANAP00000012524	ATP binding cassette subfamily G member 1.	NPC intracellular cholesterol transporter 1.	0.606
ABCG1	SCARB1	ENSANAP00000015403	ENSANAP00000034344	ATP binding cassette subfamily G member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.495
ABCG4	ABCG5	ENSANAP00000036677	ENSANAP00000026378	ATP binding cassette subfamily G member 4.	ATP binding cassette subfamily G member 5.	0.903
ABCG4	APOE	ENSANAP00000036677	ENSANAP00000021488	ATP binding cassette subfamily G member 4.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.571
ABCG5	ABCG1	ENSANAP00000026378	ENSANAP00000015403	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 1.	0.903
ABCG5	ABCG4	ENSANAP00000026378	ENSANAP00000036677	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 4.	0.903
ABCG5	ABCG8	ENSANAP00000026378	ENSANAP00000030771	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	APOB	ENSANAP00000026378	ENSANAP00000028934	ATP binding cassette subfamily G member 5.	Apolipoprotein B.	0.434
ABCG5	APOE	ENSANAP00000026378	ENSANAP00000021488	ATP binding cassette subfamily G member 5.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.538
ABCG5	NPC1	ENSANAP00000026378	ENSANAP00000012524	ATP binding cassette subfamily G member 5.	NPC intracellular cholesterol transporter 1.	0.493
ABCG5	SCARB1	ENSANAP00000026378	ENSANAP00000034344	ATP binding cassette subfamily G member 5.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.497