STRINGSTRING
YWHAE YWHAE GNB5 GNB5 PPP3CC PPP3CC ENSANAP00000015492 ENSANAP00000015492 ENSANAP00000014912 ENSANAP00000014912 SESTD1 SESTD1 ENSANAP00000013857 ENSANAP00000013857 KCNRG KCNRG ENSANAP00000013465 ENSANAP00000013465 PRKCE PRKCE BIN1 BIN1 CTTNBP2NL CTTNBP2NL PCSK9 PCSK9 REM2 REM2 CASQ2 CASQ2 OAZ3 OAZ3 OAZ1 OAZ1 GEM GEM INPP5K INPP5K ATP7A ATP7A IRS2 IRS2 GRP GRP ENSANAP00000009291 ENSANAP00000009291 SLC6A9 SLC6A9 SRI SRI KEL KEL ENPP1 ENPP1 OXSR1 OXSR1 ENSANAP00000007251 ENSANAP00000007251 ARL6IP5 ARL6IP5 AKT2 AKT2 SLC43A2 SLC43A2 FABP5 FABP5 CACNA1F CACNA1F STXBP3 STXBP3 SELENOS SELENOS NOS1 NOS1 CBARP CBARP ENSANAP00000002852 ENSANAP00000002852 MRLN MRLN KCNE3 KCNE3 THBS1 THBS1 CAB39 CAB39 ENSANAP00000000512 ENSANAP00000000512 HAMP HAMP THADA THADA CRHR1 CRHR1 ENSANAP00000039734 ENSANAP00000039734 SIRT6 SIRT6 ENSANAP00000038876 ENSANAP00000038876 PPP3CB PPP3CB TGFB1 TGFB1 LOC105717376 LOC105717376 DRD4 DRD4 GSK3A GSK3A OSR1 OSR1 CALM3 CALM3 APPL2 APPL2 RGS2 RGS2 ENSANAP00000033388 ENSANAP00000033388 CUNH4orf3 CUNH4orf3 DRD3 DRD3 SLC30A1 SLC30A1 REM1 REM1 ANK3 ANK3 HECW1 HECW1 CLIC2 CLIC2 NEDD4 NEDD4 VDAC1 VDAC1 HECW2 HECW2 SLC26A5 SLC26A5 SUMO1 SUMO1 GSTO1 GSTO1 BCL2 BCL2 ENSANAP00000030194 ENSANAP00000030194 TNF TNF MMP9 MMP9 KCNQ1 KCNQ1 KCNAB1 KCNAB1 GOPC GOPC PPP3CA PPP3CA GPR35 GPR35 STK39 STK39 PLN PLN DRD2 DRD2 EPO EPO ENSANAP00000026489 ENSANAP00000026489 RSC1A1 RSC1A1 COMMD1 COMMD1 CALM1 CALM1 PPP3R1 PPP3R1 RRAD RRAD GRB10 GRB10 KCNE4 KCNE4 OSTN OSTN PKD2 PKD2 ACTN2 ACTN2 SLC43A1 SLC43A1 FKBP1B FKBP1B CRBN CRBN ENSANAP00000021521 ENSANAP00000021521 ANO9 ANO9 PPIF PPIF CAV1 CAV1 PID1 PID1 NTSR1 NTSR1 CAMK2D CAMK2D PRKCB PRKCB CAV3 CAV3 AKT1 AKT1 EPHB2 EPHB2 KCNH2 KCNH2 FMR1 FMR1 LEP LEP ISCU ISCU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
GNB5G protein subunit beta 5. (395 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
ENSANAP00000015492Uncharacterized protein. (175 aa)
ENSANAP00000014912Small ubiquitin-related modifier. (75 aa)
SESTD1SEC14 and spectrin domain containing 1. (695 aa)
ENSANAP00000013857Uncharacterized protein. (72 aa)
KCNRGPotassium channel regulator. (273 aa)
ENSANAP00000013465Small ubiquitin-related modifier. (108 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
BIN1Bridging integrator 1. (611 aa)
CTTNBP2NLCTTNBP2 N-terminal like. (624 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (690 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (404 aa)
OAZ3Ornithine decarboxylase antizyme 3. (235 aa)
OAZ1Ornithine decarboxylase antizyme 1. (209 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (448 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
IRS2Insulin receptor substrate 2. (1369 aa)
GRPGastrin releasing peptide. (147 aa)
ENSANAP00000009291FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (110 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (687 aa)
SRIUncharacterized protein. (162 aa)
KELKell metallo-endopeptidase (Kell blood group). (732 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (898 aa)
OXSR1Oxidative stress responsive kinase 1. (527 aa)
ENSANAP00000007251Uncharacterized protein. (86 aa)
ARL6IP5PRA1 family protein. (188 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SLC43A2Solute carrier family 43 member 2. (540 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (141 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
SELENOSSelenoprotein S. (219 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1393 aa)
CBARPCACN subunit beta associated regulatory protein. (541 aa)
ENSANAP00000002852Uncharacterized protein. (48 aa)
MRLNMyoregulin. (46 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (105 aa)
THBS1Thrombospondin 1. (1173 aa)
CAB39Calcium binding protein 39. (341 aa)
ENSANAP00000000512Uncharacterized protein. (185 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
THADATHADA armadillo repeat containing. (1918 aa)
CRHR1Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family. (424 aa)
ENSANAP00000039734Protein kinase domain-containing protein. (394 aa)
SIRT6Sirtuin 6. (354 aa)
ENSANAP00000038876Uncharacterized protein. (266 aa)
PPP3CBSerine/threonine-protein phosphatase. (439 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
LOC105717376Uncharacterized protein. (273 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (407 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
ENSANAP00000033388Uncharacterized protein. (505 aa)
CUNH4orf3Uncharacterized protein. (66 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (400 aa)
SLC30A1Solute carrier family 30 member 1. (507 aa)
REM1RRAD and GEM like GTPase 1. (266 aa)
ANK3Ankyrin 3. (4375 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1590 aa)
CLIC2Chloride intracellular channel 2. (236 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1292 aa)
VDAC1Voltage dependent anion channel 1. (292 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1572 aa)
SLC26A5Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (740 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (241 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
ENSANAP00000030194GST N-terminal domain-containing protein. (199 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (419 aa)
GOPCPDZ domain-containing protein. (463 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GPR35G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. (340 aa)
STK39Serine/threonine kinase 39. (538 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
ENSANAP00000026489Uncharacterized protein. (270 aa)
RSC1A1Regulator of solute carriers 1. (646 aa)
COMMD1Copper metabolism domain containing 1. (190 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
PPP3R1Uncharacterized protein. (189 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (293 aa)
GRB10Uncharacterized protein. (587 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (217 aa)
OSTNOsteocrin. (133 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (951 aa)
ACTN2Actinin alpha 2. (871 aa)
SLC43A1Solute carrier family 43 member 1. (559 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
CRBNCereblon. (494 aa)
ENSANAP00000021521Rad60-SLD domain-containing protein. (94 aa)
ANO9Anoctamin. (732 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PID1Phosphotyrosine interaction domain containing 1. (250 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
EPHB2EPH receptor B2. (1114 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1149 aa)
FMR1Fragile X mental retardation 1. (632 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (168 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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