STRINGSTRING
CXCR3 CXCR3 GRIN1 GRIN1 CXCL11 CXCL11 PKD2 PKD2 ACE2 ACE2 LRRC52 LRRC52 ACTN2 ACTN2 LOC105709173 LOC105709173 CDK5 CDK5 SHANK3 SHANK3 ANK2 ANK2 SLC34A1 SLC34A1 RAMP3 RAMP3 STAC3 STAC3 SLC9A1 SLC9A1 NIPSNAP2 NIPSNAP2 CAV1 CAV1 NTSR1 NTSR1 P2RX4 P2RX4 CTSS CTSS P2RX2 P2RX2 CHP2 CHP2 NPPA NPPA EPHB2 EPHB2 WNK1 WNK1 KCNH2 KCNH2 BAX BAX PSEN1 PSEN1 LRRC38 LRRC38 BAK1 BAK1 DMD DMD KCNN4 KCNN4 PPP3CC PPP3CC ENSANAP00000015492 ENSANAP00000015492 R3HDM2 R3HDM2 ADRB2 ADRB2 ENSANAP00000014912 ENSANAP00000014912 HSPA2 HSPA2 GALR2 GALR2 PLCG2 PLCG2 CEMIP CEMIP ENSANAP00000013465 ENSANAP00000013465 TOR2A TOR2A CACNB3 CACNB3 P2RX7 P2RX7 WNK2 WNK2 WNK3 WNK3 CHP1 CHP1 ATPSCKMT ATPSCKMT VMP1 VMP1 SRI SRI CXCL10 CXCL10 ENSANAP00000008458 ENSANAP00000008458 ENSANAP00000008033 ENSANAP00000008033 ENSANAP00000007251 ENSANAP00000007251 ATP1B2 ATP1B2 STAC STAC LACRT LACRT EDN3 EDN3 P2RX1 P2RX1 ENSANAP00000005584 ENSANAP00000005584 CALCR CALCR PDPK1 PDPK1 TRPC1 TRPC1 COX17 COX17 EHD3 EHD3 KCNIP2 KCNIP2 AKAP7 AKAP7 F2R F2R COA8 COA8 NOS1 NOS1 LRRC55 LRRC55 AMIGO1 AMIGO1 ENSANAP00000002875 ENSANAP00000002875 CFTR CFTR ARC ARC P2RY6 P2RY6 APLNR APLNR FXYD1 FXYD1 GPER1 GPER1 ENSANAP00000000512 ENSANAP00000000512 PLCG1 PLCG1 ENSANAP00000000129 ENSANAP00000000129 ANK3 ANK3 TESC TESC THY1 THY1 ADCYAP1R1 ADCYAP1R1 F2RL3 F2RL3 ABCC8 ABCC8 KCNMB1 KCNMB1 P2RX3 P2RX3 AKAP6 AKAP6 KCNK3 KCNK3 NPSR1 NPSR1 CALM3 CALM3 RYR2 RYR2 CD19 CD19 BDKRB1 BDKRB1 NOS1AP NOS1AP PLA2G1B PLA2G1B CAPN3 CAPN3 ATP2A1 ATP2A1 IFNGR2 IFNGR2 ENSANAP00000041804 ENSANAP00000041804 GAL GAL NDUFA4 NDUFA4 STIM1 STIM1 RNF207 RNF207 CACNG4 CACNG4 STAC2 STAC2 ENSANAP00000024200 ENSANAP00000024200 CACNG2 CACNG2 ARL6IP1 ARL6IP1 ANTKMT ANTKMT R3HDM1 R3HDM1 MS4A1 MS4A1 JPH2 JPH2 CLTRN CLTRN TREM2 TREM2 DRD4 DRD4 AKAP9 AKAP9 RGS7 RGS7 PPP3CB PPP3CB CACNA2D1 CACNA2D1 CACNB4 CACNB4 CASQ1 CASQ1 F2 F2 CRACR2A CRACR2A WNK4 WNK4 ANO6 ANO6 DNM2 DNM2 ENSANAP00000025969 ENSANAP00000025969 PDZK1 PDZK1 LOC105707120 LOC105707120 SLC17A8 SLC17A8 ENSANAP00000026740 ENSANAP00000026740 LOC105725318 LOC105725318 HTT HTT STK39 STK39 ATP1B3 ATP1B3 PINK1 PINK1 CX3CL1 CX3CL1 G6PD G6PD PPP3CA PPP3CA GRM6 GRM6 KCNQ1 KCNQ1 RELN RELN TRPC6 TRPC6 ENSANAP00000030194 ENSANAP00000030194 GLRX GLRX TRPC3 TRPC3 GSTO1 GSTO1 CACNB2 CACNB2 KCNC2 KCNC2 ATP1B1 ATP1B1 ENSANAP00000031370 ENSANAP00000031370 EDN1 EDN1 CALM1 CALM1 ASPH ASPH PPP3R1 PPP3R1 CXCL9 CXCL9 STIM2 STIM2 ABL1 ABL1 EDNRA EDNRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (367 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
CXCL11C-X-C motif chemokine. (96 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (951 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
LRRC52Leucine rich repeat containing 52. (313 aa)
ACTN2Actinin alpha 2. (871 aa)
LOC105709173Uncharacterized protein. (2229 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (314 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1700 aa)
ANK2Ankyrin 2. (3962 aa)
SLC34A1Solute carrier family 34 member 1. (676 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
NIPSNAP2Nipsnap homolog 2. (286 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (362 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (330 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (445 aa)
CHP2Calcineurin like EF-hand protein 2. (211 aa)
NPPANatriuretic peptide A. (161 aa)
EPHB2EPH receptor B2. (1114 aa)
WNK1WNK lysine deficient protein kinase 1. (2831 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1149 aa)
BAXBCL2 associated X, apoptosis regulator. (193 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
LRRC38Leucine rich repeat containing 38. (298 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
DMDUncharacterized protein. (1243 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (427 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
ENSANAP00000015492Uncharacterized protein. (175 aa)
R3HDM2Uncharacterized protein. (1009 aa)
ADRB2Adrenoceptor beta 2. (426 aa)
ENSANAP00000014912Small ubiquitin-related modifier. (75 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (601 aa)
GALR2Galanin receptor 2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CEMIPCell migration inducing hyaluronidase 1. (1267 aa)
ENSANAP00000013465Small ubiquitin-related modifier. (108 aa)
TOR2ATorsin. (321 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
WNK2WNK lysine deficient protein kinase 2. (2258 aa)
WNK3WNK lysine deficient protein kinase 3. (1717 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (232 aa)
VMP1Vacuole membrane protein 1. (446 aa)
SRIUncharacterized protein. (162 aa)
CXCL10C-X-C motif chemokine. (97 aa)
ENSANAP00000008458Uncharacterized protein. (1994 aa)
ENSANAP00000008033Uncharacterized protein. (318 aa)
ENSANAP00000007251Uncharacterized protein. (86 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa)
STACSH3 and cysteine rich domain. (395 aa)
LACRTLacritin. (137 aa)
EDN3Endothelin 3. (230 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
ENSANAP00000005584Uncharacterized protein. (76 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (474 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (572 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (793 aa)
COX17Cytochrome c oxidase copper chaperone COX17. (98 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (307 aa)
AKAP7A-kinase anchoring protein 7. (351 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
COA8Cytochrome c oxidase assembly factor 8. (206 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1393 aa)
LRRC55Leucine rich repeat containing 55. (316 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
ENSANAP00000002875Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (235 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1226 aa)
ARCActivity regulated cytoskeleton associated protein. (398 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ENSANAP00000000512Uncharacterized protein. (185 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
ENSANAP00000000129Uncharacterized protein. (82 aa)
ANK3Ankyrin 3. (4375 aa)
TESCTescalcin. (214 aa)
THY1Thy-1 cell surface antigen. (161 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (513 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (385 aa)
ABCC8ATP binding cassette subfamily C member 8. (1572 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
AKAP6A-kinase anchoring protein 6. (2320 aa)
KCNK3Potassium channel subfamily K member. (352 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (385 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
RYR2Ryanodine receptor 2. (4650 aa)
CD19CD19 molecule. (565 aa)
BDKRB1Bradykinin receptor B1. (282 aa)
NOS1APPID domain-containing protein. (690 aa)
PLA2G1BPhospholipase A(2). (145 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (823 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1002 aa)
IFNGR2Interferon gamma receptor 2. (328 aa)
ENSANAP00000041804EF-hand domain-containing protein. (175 aa)
GALGalanin and GMAP prepropeptide. (121 aa)
NDUFA4Uncharacterized protein. (82 aa)
STIM1Stromal interaction molecule 1. (790 aa)
RNF207Ring finger protein 207. (634 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
STAC2SH3 and cysteine rich domain 2. (391 aa)
ENSANAP00000024200Protein kinase domain-containing protein. (279 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ARL6IP1ADP ribosylation factor like GTPase 6 interacting protein 1. (203 aa)
ANTKMTAdenine nucleotide translocase lysine methyltransferase. (235 aa)
R3HDM1R3H domain containing 1. (1101 aa)
MS4A1Membrane spanning 4-domains A1. (295 aa)
JPH2Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (696 aa)
CLTRNCollectrin domain-containing protein. (222 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (407 aa)
AKAP9A-kinase anchoring protein 9. (3897 aa)
RGS7Regulator of G protein signaling 7. (487 aa)
PPP3CBSerine/threonine-protein phosphatase. (439 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (401 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
CRACR2ACalcium release activated channel regulator 2A. (731 aa)
WNK4WNK lysine deficient protein kinase 4. (1229 aa)
ANO6Anoctamin. (929 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
ENSANAP00000025969FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (62 aa)
PDZK1PDZ domain containing 1. (520 aa)
LOC105707120Uncharacterized protein. (824 aa)
SLC17A8Solute carrier family 17 member 8. (589 aa)
ENSANAP00000026740Uncharacterized protein. (82 aa)
LOC105725318Uncharacterized protein. (954 aa)
HTTHuntingtin. (3132 aa)
STK39Serine/threonine kinase 39. (538 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
PINK1PTEN induced kinase 1. (525 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (395 aa)
G6PDGlucose-6-phosphate dehydrogenase. (556 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GRM6Glutamate metabotropic receptor 6. (856 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
RELNReelin. (3460 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
ENSANAP00000030194GST N-terminal domain-containing protein. (199 aa)
GLRXGlutaredoxin. (106 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (241 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (663 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (618 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ENSANAP00000031370Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (235 aa)
EDN1Endothelin 1. (212 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
ASPHAspartate beta-hydroxylase. (764 aa)
PPP3R1Uncharacterized protein. (189 aa)
CXCL9C-X-C motif chemokine. (126 aa)
STIM2Stromal interaction molecule 2. (754 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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