82 items (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LCAT	Lecithin-cholesterol acyltransferase. (442 aa)
	APOB	Apolipoprotein B. (3824 aa)
	LIPC	Lipase C, hepatic type. (499 aa)
	PLA2G10	Phospholipase A(2). (165 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (640 aa)
	DGAT2	Diacylglycerol O-acyltransferase 2. (388 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2220 aa)
	SEC24A	SEC24 homolog A, COPII coat complex component. (975 aa)
	LIMA1	LIM domain and actin binding 1. (760 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1092 aa)
	CD24	Uncharacterized protein. (119 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	CYP39A1	Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (458 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (452 aa)
	PLSCR3	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (308 aa)
	MED13	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2174 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (381 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (281 aa)
	ABCA2	ATP binding cassette subfamily A member 2. (2349 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	DISP3	Dispatched RND transporter family member 3. (1345 aa)
	SOAT1	O-acyltransferase. (519 aa)
	ENSANAP00000020244	Uncharacterized protein. (87 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1143 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (771 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1597 aa)
	SLC37A4	Solute carrier family 37 member 4. (451 aa)
	ENSANAP00000018347	RRM domain-containing protein. (261 aa)
	MALRD1	MAM and LDL receptor class A domain containing 1. (1851 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (280 aa)
	LPL	Lipoprotein lipase. (453 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (603 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (615 aa)
	ENSANAP00000014786	Uncharacterized protein. (142 aa)
	APOA2	Apolipoprotein A2. (132 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	XBP1	BZIP domain-containing protein. (379 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (661 aa)
	ENSANAP00000013254	Uncharacterized protein. (253 aa)
	RORA	RAR related orphan receptor A. (523 aa)
	SOAT2	O-acyltransferase. (526 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (690 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)
	CETP	Cholesteryl ester transfer protein. (521 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (464 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (506 aa)
	FABP3	Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1323 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (343 aa)
	RALYL	RALY RNA binding protein like. (304 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	COMMD9	COMM domain containing 9. (213 aa)
	TSPO	Uncharacterized protein. (169 aa)
	FGFR4	Fibroblast growth factor receptor. (691 aa)
	MTTP	Microsomal triglyceride transfer protein. (870 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (541 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (651 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (486 aa)
	PLA2G12B	Phospholipase A2 group XIIB. (195 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1590 aa)
	NUS1	Uncharacterized protein. (293 aa)
	ENSANAP00000038778	Uncharacterized protein. (406 aa)
	TMEM97	Transmembrane protein 97. (200 aa)
	LDLR	Low density lipoprotein receptor. (786 aa)
	SIRT1	Sirtuin 1. (751 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)
	TTC39A	Tetratricopeptide repeat domain 39A. (613 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (459 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (551 aa)
	ENSANAP00000000446	Uncharacterized protein. (158 aa)
	EPHX2	Epoxide hydrolase 2. (555 aa)
	ENSANAP00000001281	Uncharacterized protein. (78 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (445 aa)
	ANGPTL3	Angiopoietin like 3. (460 aa)
	GRAMD1B	GRAM domain containing 1B. (877 aa)
	RALY	RALY heterogeneous nuclear ribonucleoprotein. (307 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
	LIPG	Lipase G, endothelial type. (500 aa)
	GPIHBP1	Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (180 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ANGPTL3	ENSANAP00000031638	ENSANAP00000001778	ATP binding cassette subfamily A member 1.	Angiopoietin like 3.	0.564
ABCA1	APOA2	ENSANAP00000031638	ENSANAP00000028816	ATP binding cassette subfamily A member 1.	Apolipoprotein A2.	0.501
ABCA1	APOA5	ENSANAP00000031638	ENSANAP00000025609	ATP binding cassette subfamily A member 1.	Apolipoprotein A5.	0.405
ABCA1	APOB	ENSANAP00000031638	ENSANAP00000028934	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.614
ABCA1	APOE	ENSANAP00000031638	ENSANAP00000021488	ATP binding cassette subfamily A member 1.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.764
ABCA1	CETP	ENSANAP00000031638	ENSANAP00000011865	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein.	0.657
ABCA1	CYP7A1	ENSANAP00000031638	ENSANAP00000003800	ATP binding cassette subfamily A member 1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.550
ABCA1	INSIG1	ENSANAP00000031638	ENSANAP00000017704	ATP binding cassette subfamily A member 1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.497
ABCA1	LCAT	ENSANAP00000031638	ENSANAP00000007340	ATP binding cassette subfamily A member 1.	Lecithin-cholesterol acyltransferase.	0.572
ABCA1	LIPG	ENSANAP00000031638	ENSANAP00000005449	ATP binding cassette subfamily A member 1.	Lipase G, endothelial type.	0.510
ABCA1	MTTP	ENSANAP00000031638	ENSANAP00000007796	ATP binding cassette subfamily A member 1.	Microsomal triglyceride transfer protein.	0.538
ABCA1	MYLIP	ENSANAP00000031638	ENSANAP00000001441	ATP binding cassette subfamily A member 1.	Myosin regulatory light chain interacting protein.	0.426
ABCA1	NPC1	ENSANAP00000031638	ENSANAP00000012524	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 1.	0.574
ABCA1	NR1H2	ENSANAP00000031638	ENSANAP00000034385	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 2.	0.849
ABCA1	NR1H3	ENSANAP00000031638	ENSANAP00000041401	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 3.	0.790
ABCA1	NR1H4	ENSANAP00000031638	ENSANAP00000025305	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 4.	0.669
ABCA1	PCSK9	ENSANAP00000031638	ENSANAP00000012526	ATP binding cassette subfamily A member 1.	Proprotein convertase subtilisin/kexin type 9.	0.493
ABCA1	SCARB1	ENSANAP00000031638	ENSANAP00000034344	ATP binding cassette subfamily A member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.539
ABCA1	SREBF2	ENSANAP00000031638	ENSANAP00000019976	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 2.	0.572
ABCA2	APOE	ENSANAP00000021360	ENSANAP00000021488	ATP binding cassette subfamily A member 2.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.422