(93 nodes) Regulation of carbohydrate biosynthetic process network (Aotus nancymaae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SIRT6	Sirtuin 6. (354 aa)
	PPP1R3E	Protein phosphatase 1 regulatory subunit 3E. (230 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (655 aa)
	PGP	Phosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	C1QTNF3	C1q domain-containing protein. (319 aa)
	CD244	CD244 molecule. (363 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
	NTSR1	Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	ENSANAP00000015998	Uncharacterized protein. (120 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (419 aa)
	EP300	E1A binding protein p300. (2401 aa)
	SOGA1	Suppressor of glucose, autophagy associated 1. (1630 aa)
	ENSANAP00000014529	USP7_C2 domain-containing protein. (291 aa)
	CRY1	Cryptochrome circadian regulator 1. (586 aa)
	PASK	PAS domain containing serine/threonine kinase. (1312 aa)
	DGKQ	Diacylglycerol kinase. (913 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (448 aa)
	USP7	Uncharacterized protein; Belongs to the peptidase C19 family. (1101 aa)
	MAS1	MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
	IRS2	Insulin receptor substrate 2. (1369 aa)
	GPT	Glutamic--pyruvic transaminase. (496 aa)
	DYRK2	Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (415 aa)
	FBP1	FBPase domain-containing protein; Belongs to the FBPase class 1 family. (338 aa)
	KAT2A	Lysine acetyltransferase 2A. (844 aa)
	ARPP19	cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (130 aa)
	NR3C1	Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (777 aa)
	PPP1R3F	Protein phosphatase 1 regulatory subunit 3F. (795 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	FAM3C	Family with sequence similarity 3 member C. (227 aa)
	ENSANAP00000019979	Fork-head domain-containing protein. (535 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
	FAM3A	ILEI domain-containing protein. (237 aa)
	GCK	Phosphotransferase. (466 aa)
	PDK2	Protein-serine/threonine kinase. (385 aa)
	SELENOS	Selenoprotein S. (219 aa)
	SESN2	Sestrin 2. (480 aa)
	GRB10	Uncharacterized protein. (587 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (813 aa)
	EPM2AIP1	EPM2A interacting protein 1. (607 aa)
	PLEK	Pleckstrin. (350 aa)
	NNMT	Nicotinamide N-methyltransferase. (259 aa)
	LOC105715008	Uncharacterized protein. (935 aa)
	GCG	Glucagon. (180 aa)
	DGAT2	Diacylglycerol O-acyltransferase 2. (388 aa)
	SIRT7	Sirtuin 7. (400 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A. (1118 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (513 aa)
	ENSANAP00000033388	Uncharacterized protein. (505 aa)
	SORBS1	Sorbin and SH3 domain containing 1. (1294 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
	C1QTNF12	C1q and TNF related 12. (278 aa)
	GSK3A	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (802 aa)
	SIRT1	Sirtuin 1. (751 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	ENSANAP00000039038	Uncharacterized protein. (274 aa)
	SDHAF3	Succinate dehydrogenase complex assembly factor 3. (125 aa)
	ZNF692	Zinc finger protein 692. (519 aa)
	WDR5	WD repeat domain 5. (353 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (328 aa)
	P2RY1	Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	IRS1	Insulin receptor substrate 1. (1245 aa)
	LEPR	Leptin receptor. (1165 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
	IGF1	Insulin like growth factor 1. (201 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
	ERFE	Erythroferrone. (323 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (898 aa)
	DDB1	Damage specific DNA binding protein 1. (1140 aa)
	LOC105710091	Uncharacterized protein. (738 aa)
	ENSANAP00000007876	ILEI domain-containing protein. (231 aa)
	INSR	Tyrosine-protein kinase receptor. (1302 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	LOC105709935	FBPase domain-containing protein; Belongs to the FBPase class 1 family. (317 aa)
	CLK2	Secretory carrier-associated membrane protein. (761 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (414 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCYAP1R1	GCG	ENSANAP00000033157	ENSANAP00000030394	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	Glucagon.	0.836
ADCYAP1R1	PTH	ENSANAP00000033157	ENSANAP00000011415	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.488
ADIPOQ	IGF1	ENSANAP00000019740	ENSANAP00000010334	Adiponectin, C1Q and collagen domain containing.	Insulin like growth factor 1.	0.572
ADIPOQ	IRS1	ENSANAP00000019740	ENSANAP00000000658	Adiponectin, C1Q and collagen domain containing.	Insulin receptor substrate 1.	0.538
ADIPOQ	LEP	ENSANAP00000019740	ENSANAP00000017166	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.922
ADIPOQ	LEPR	ENSANAP00000019740	ENSANAP00000000533	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.497
ADIPOQ	PPARA	ENSANAP00000019740	ENSANAP00000015794	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.547
ADIPOQ	PPARGC1A	ENSANAP00000019740	ENSANAP00000036857	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.544
ADIPOQ	SIRT1	ENSANAP00000019740	ENSANAP00000036943	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.538
AKT1	AKT2	ENSANAP00000019436	ENSANAP00000006734	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.977
AKT1	EGF	ENSANAP00000019436	ENSANAP00000020409	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.545
AKT1	ENSANAP00000019979	ENSANAP00000019436	ENSANAP00000019979	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.990
AKT1	EP300	ENSANAP00000019436	ENSANAP00000015649	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	E1A binding protein p300.	0.846
AKT1	GSK3A	ENSANAP00000019436	ENSANAP00000035471	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	0.964
AKT1	GSK3B	ENSANAP00000019436	ENSANAP00000016809	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.990
AKT1	IGF1	ENSANAP00000019436	ENSANAP00000010334	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin like growth factor 1.	0.591
AKT1	IGF2	ENSANAP00000019436	ENSANAP00000001862	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin like growth factor 2.	0.419
AKT1	IRS1	ENSANAP00000019436	ENSANAP00000000658	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.616
AKT1	IRS2	ENSANAP00000019436	ENSANAP00000010561	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.556
AKT1	LEP	ENSANAP00000019436	ENSANAP00000017166	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.497