(21 nodes) Positive regulation of epidermal cell differentiation network (Aotus nancymaae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	ATOH1	Atonal bHLH transcription factor 1. (355 aa)
	KDF1	Keratinocyte differentiation factor 1. (398 aa)
	FOXC1	Forkhead box C1. (539 aa)
	NOTCH1	Notch receptor 1. (2527 aa)
	SULT2B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (331 aa)
	NCOA3	Nuclear receptor coactivator. (1429 aa)
	ETV4	ETS variant 4. (484 aa)
	IL20	Interleukin 20. (176 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
	SFRP4	Secreted frizzled related protein 4. (369 aa)
	VDR	Vitamin D receptor. (400 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	PTCH1	Patched 1. (1453 aa)
	LOC105730715	B30.2/SPRY domain-containing protein. (565 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (677 aa)
	PTCH2	Patched 2. (1203 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (2121 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	PTCH1	ENSANAP00000036913	ENSANAP00000023746	Bone morphogenetic protein 4.	Patched 1.	0.419
BMP4	PTCH2	ENSANAP00000036913	ENSANAP00000033372	Bone morphogenetic protein 4.	Patched 2.	0.419
CYP27B1	MED1	ENSANAP00000023124	ENSANAP00000040646	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.852
CYP27B1	NCOA3	ENSANAP00000023124	ENSANAP00000013015	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Nuclear receptor coactivator.	0.736
CYP27B1	VDR	ENSANAP00000023124	ENSANAP00000021287	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Vitamin D receptor.	0.602
ETV4	NCOA3	ENSANAP00000011881	ENSANAP00000013015	ETS variant 4.	Nuclear receptor coactivator.	0.831
LOC105730715	NOTCH1	ENSANAP00000026099	ENSANAP00000014724	B30.2/SPRY domain-containing protein.	Notch receptor 1.	0.612
MED1	CYP27B1	ENSANAP00000040646	ENSANAP00000023124	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.852
MED1	NCOA3	ENSANAP00000040646	ENSANAP00000013015	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.938
MED1	VDR	ENSANAP00000040646	ENSANAP00000021287	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D receptor.	0.927
NCOA3	CYP27B1	ENSANAP00000013015	ENSANAP00000023124	Nuclear receptor coactivator.	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.736
NCOA3	ETV4	ENSANAP00000013015	ENSANAP00000011881	Nuclear receptor coactivator.	ETS variant 4.	0.831
NCOA3	MED1	ENSANAP00000013015	ENSANAP00000040646	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.938
NCOA3	VDR	ENSANAP00000013015	ENSANAP00000021287	Nuclear receptor coactivator.	Vitamin D receptor.	0.909
NOTCH1	LOC105730715	ENSANAP00000014724	ENSANAP00000026099	Notch receptor 1.	B30.2/SPRY domain-containing protein.	0.612
PTCH1	BMP4	ENSANAP00000023746	ENSANAP00000036913	Patched 1.	Bone morphogenetic protein 4.	0.419
PTCH1	PTCH2	ENSANAP00000023746	ENSANAP00000033372	Patched 1.	Patched 2.	0.913
PTCH1	SFRP4	ENSANAP00000023746	ENSANAP00000021026	Patched 1.	Secreted frizzled related protein 4.	0.526
PTCH2	BMP4	ENSANAP00000033372	ENSANAP00000036913	Patched 2.	Bone morphogenetic protein 4.	0.419
PTCH2	PTCH1	ENSANAP00000033372	ENSANAP00000023746	Patched 2.	Patched 1.	0.913