STRINGSTRING
CSF1 CSF1 KITLG KITLG LOC105725379 LOC105725379 IFNG IFNG MTURN MTURN PLA2G3 PLA2G3 HIF1A HIF1A TAL1 TAL1 THPO THPO TRIB1 TRIB1 RAB7B RAB7B IL34 IL34 IL23A IL23A NOTCH2 NOTCH2 SMAP1 SMAP1 ARNT ARNT SLC9B2 SLC9B2 NEDD9 NEDD9 IL20 IL20 PPARGC1B PPARGC1B PRMT1 PRMT1 RB1 RB1 ENSANAP00000008152 ENSANAP00000008152 PITHD1 PITHD1 INHBA INHBA CSF3 CSF3 ANKRD54 ANKRD54 HAX1 HAX1 JAG1 JAG1 ETS1 ETS1 ROR2 ROR2 CD74 CD74 TNFSF11 TNFSF11 HSF1 HSF1 FAXDC2 FAXDC2 NCKAP1L NCKAP1L POU4F1 POU4F1 RHEX RHEX CREB1 CREB1 DCSTAMP DCSTAMP HCLS1 HCLS1 GPR68 GPR68 TRAF6 TRAF6 STAT1 STAT1 ACVR1B ACVR1B ABCB10 ABCB10 GATA2 GATA2 PRKDC PRKDC CASP8 CASP8 FOS FOS SCIN SCIN RUNX1 RUNX1 ACVR2A ACVR2A FADD FADD BRD1 BRD1 LEF1 LEF1 CD4 CD4 ISG15 ISG15 PPP3CA PPP3CA GATA1 GATA1 KAT7 KAT7 POU4F2 POU4F2 TNF TNF RIPK1 RIPK1 LOC105727567 LOC105727567 PRKCA PRKCA LIF LIF TESC TESC HOXA5 HOXA5 ACIN1 ACIN1 CD101 CD101 TMEM64 TMEM64 ENSANAP00000035211 ENSANAP00000035211 FAM210B FAM210B NINJ1 NINJ1 TREM2 TREM2 TGFB1 TGFB1 ZNF16 ZNF16 STAT3 STAT3 IL17A IL17A ENSANAP00000037676 ENSANAP00000037676 RCOR1 RCOR1 IL23R IL23R MPL MPL OCSTAMP OCSTAMP INPP5D INPP5D FES FES ZFP36L1 ZFP36L1 STAT5B STAT5B MED1 MED1 CTNNBIP1 CTNNBIP1 MAPK14 MAPK14 ENSANAP00000041804 ENSANAP00000041804 KLF10 KLF10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSF1Colony stimulating factor 1. (619 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
LOC105725379C-X-C motif chemokine. (102 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (131 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
THPOThrombopoietin. (307 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
RAB7BRAB7B, member RAS oncogene family. (202 aa)
IL34Interleukin 34. (230 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
NOTCH2Notch receptor 2. (2471 aa)
SMAP1Small ArfGAP 1. (468 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
IL20Interleukin 20. (176 aa)
PPARGC1BPPARG coactivator 1 beta. (1022 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (372 aa)
RB1RB transcriptional corepressor 1. (925 aa)
ENSANAP00000008152Uncharacterized protein. (216 aa)
PITHD1PITH domain containing 1. (211 aa)
INHBAInhibin subunit beta A. (426 aa)
CSF3Colony stimulating factor 3. (207 aa)
ANKRD54Ankyrin repeat domain 54. (299 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (283 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (899 aa)
CD74CD74 molecule. (280 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
HSF1Heat shock transcription factor 1. (529 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (333 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
POU4F1POU domain protein. (420 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (177 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (471 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (473 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (370 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
STAT1Signal transducer and activator of transcription. (781 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (545 aa)
ABCB10ATP binding cassette subfamily B member 10. (738 aa)
GATA2GATA binding protein 2. (470 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4076 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (525 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SCINScinderin. (715 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (462 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (207 aa)
BRD1Bromodomain containing 1. (1087 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
CD4Ig-like domain-containing protein. (457 aa)
ISG15ISG15 ubiquitin like modifier. (166 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GATA1GATA binding protein 1. (413 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (613 aa)
POU4F2POU domain protein. (353 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
LOC105727567Uncharacterized protein. (247 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
TESCTescalcin. (214 aa)
HOXA5Homeobox A5. (270 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1351 aa)
CD101CD101 molecule. (1000 aa)
TMEM64Transmembrane protein 64. (373 aa)
ENSANAP00000035211Uncharacterized protein. (289 aa)
FAM210BFamily with sequence similarity 210 member B. (192 aa)
NINJ1Ninjurin 1. (152 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
ZNF16Zinc finger protein 16. (711 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
IL17AInterleukin 17A. (153 aa)
ENSANAP00000037676Uncharacterized protein. (167 aa)
RCOR1REST corepressor 1. (471 aa)
IL23RInterleukin 23 receptor. (575 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (689 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (532 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1108 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (808 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSANAP00000041804EF-hand domain-containing protein. (175 aa)
KLF10Kruppel like factor 10. (480 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.