(41 nodes) Negative regulation of osteoblast differentiation network (Aotus nancymaae)

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second shell of interactors

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Predicted Interactions

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Your Input:
	CRIM1	Cysteine rich transmembrane BMP regulator 1. (1037 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	NOTCH1	Notch receptor 1. (2527 aa)
	HOXA2	Homeobox A2. (375 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (273 aa)
	UCMA	Upper zone of growth plate and cartilage matrix associated. (132 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1006 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
	RORB	RAR related orphan receptor B. (459 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (119 aa)
	OSTN	Osteocrin. (133 aa)
	PTCH1	Patched 1. (1453 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1204 aa)
	AXIN2	Axin 2. (843 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	ENSANAP00000026192	Uncharacterized protein. (31 aa)
	RANBP3L	RAN binding protein 3 like. (487 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	NOCT	Nocturnin. (431 aa)
	RIOX1	Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (631 aa)
	LIMD1	LIM domains containing 1. (676 aa)
	SMAD6	Mothers against decapentaplegic homolog. (494 aa)
	SKI	SKI proto-oncogene. (726 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (230 aa)
	GDF10	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (862 aa)
	SOX9	SRY-box transcription factor 9. (505 aa)
	MEN1	Menin 1. (610 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (944 aa)
	TNFAIP6	TNF alpha induced protein 6. (277 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (424 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (520 aa)
	TNN	Tenascin N. (1298 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	TMEM64	Transmembrane protein 64. (373 aa)
	ENSANAP00000033932	Uncharacterized protein. (576 aa)
	AREG	Amphiregulin. (252 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	TNFAIP6	ENSANAP00000031383	ENSANAP00000012295	Amphiregulin.	TNF alpha induced protein 6.	0.504
AXIN2	SFRP1	ENSANAP00000025255	ENSANAP00000007291	Axin 2.	Secreted frizzled related protein 1.	0.525
BAMBI	CHRD	ENSANAP00000036116	ENSANAP00000011797	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.493
BAMBI	SMAD3	ENSANAP00000036116	ENSANAP00000000216	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.543
BAMBI	SMAD6	ENSANAP00000036116	ENSANAP00000005203	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.724
CHRD	BAMBI	ENSANAP00000011797	ENSANAP00000036116	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.493
CHRD	GDF10	ENSANAP00000011797	ENSANAP00000009661	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Bone morphogenetic protein 3; Belongs to the TGF-beta family.	0.434
CHRD	NOG	ENSANAP00000011797	ENSANAP00000000648	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.520
CHRD	SMAD6	ENSANAP00000011797	ENSANAP00000005203	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Mothers against decapentaplegic homolog.	0.518
CHRD	TNFAIP6	ENSANAP00000011797	ENSANAP00000012295	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	TNF alpha induced protein 6.	0.722
CHRD	TWSG1	ENSANAP00000011797	ENSANAP00000023993	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Twisted gastrulation BMP signaling modulator 1.	0.702
ENSANAP00000033932	SMAD3	ENSANAP00000033932	ENSANAP00000000216	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.704
GDF10	CHRD	ENSANAP00000009661	ENSANAP00000011797	Bone morphogenetic protein 3; Belongs to the TGF-beta family.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.434
MEN1	SMAD3	ENSANAP00000010955	ENSANAP00000000216	Menin 1.	Mothers against decapentaplegic homolog.	0.704
NOG	CHRD	ENSANAP00000000648	ENSANAP00000011797	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.520
NOTCH1	SMAD3	ENSANAP00000014724	ENSANAP00000000216	Notch receptor 1.	Mothers against decapentaplegic homolog.	0.557
NOTCH1	TNF	ENSANAP00000014724	ENSANAP00000029597	Notch receptor 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.433
PTCH1	SFRP1	ENSANAP00000023746	ENSANAP00000007291	Patched 1.	Secreted frizzled related protein 1.	0.526
PTCH1	SUFU	ENSANAP00000023746	ENSANAP00000037565	Patched 1.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.645
SFRP1	AXIN2	ENSANAP00000007291	ENSANAP00000025255	Secreted frizzled related protein 1.	Axin 2.	0.525