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SPIRE2 SPIRE2 PARP3 PARP3 FGF10 FGF10 MGMT MGMT KMT5C KMT5C FANCB FANCB PIAS4 PIAS4 TIGAR TIGAR MMS19 MMS19 EYA4 EYA4 CCDC117 CCDC117 ENSANAP00000010942 ENSANAP00000010942 PRKCG PRKCG DPF1 DPF1 PARP9 PARP9 OOEP OOEP DPF3 DPF3 UIMC1 UIMC1 MBTD1 MBTD1 EYA3 EYA3 INO80B INO80B SMARCA2 SMARCA2 WRAP53 WRAP53 EPC1 EPC1 TRIM28 TRIM28 ENSANAP00000019133 ENSANAP00000019133 EYA1 EYA1 ERCC6 ERCC6 SMARCD2 SMARCD2 RPS3 RPS3 LOC105705170 LOC105705170 FAM168A FAM168A MEAF6 MEAF6 ACTL6A ACTL6A BCL7A BCL7A MCRS1 MCRS1 BABAM1 BABAM1 LOC110569273 LOC110569273 ACTR8 ACTR8 ENSANAP00000021522 ENSANAP00000021522 PRKDC PRKDC KHDC3L KHDC3L SPIDR SPIDR NPAS2 NPAS2 SHLD1 SHLD1 ENSANAP00000023031 ENSANAP00000023031 POGZ POGZ ENSANAP00000023178 ENSANAP00000023178 KMT5B KMT5B MAD2L2 MAD2L2 INO80D INO80D BABAM2 BABAM2 LOC105721409 LOC105721409 SMARCC1 SMARCC1 ZCWPW1 ZCWPW1 DHX9 DHX9 MRNIP MRNIP ENSANAP00000026808 ENSANAP00000026808 ARID1B ARID1B SETMAR SETMAR CEBPG CEBPG BRD8 BRD8 SLF2 SLF2 ENSANAP00000027633 ENSANAP00000027633 RNF168 RNF168 ENSANAP00000028020 ENSANAP00000028020 DMAP1 DMAP1 ENSANAP00000028165 ENSANAP00000028165 TRRAP TRRAP RNF8 RNF8 EP400 EP400 SMARCB1 SMARCB1 SHLD2 SHLD2 ACTL6B ACTL6B INO80 INO80 SMARCE1 SMARCE1 VPS72 VPS72 RUVBL1 RUVBL1 HDGFL2 HDGFL2 PARP1 PARP1 YEATS4 YEATS4 HELQ HELQ TMEM161A TMEM161A SMARCC2 SMARCC2 PBRM1 PBRM1 FH FH ENSANAP00000034595 ENSANAP00000034595 TIMELESS TIMELESS SPIRE1 SPIRE1 HDAC10 HDAC10 DPF2 DPF2 FOXM1 FOXM1 KAT5 KAT5 ARID2 ARID2 SMCHD1 SMCHD1 DTX3L DTX3L ENSANAP00000036359 ENSANAP00000036359 SIRT1 SIRT1 ENSANAP00000037068 ENSANAP00000037068 EGFR EGFR ABRAXAS1 ABRAXAS1 INO80E INO80E RUVBL2 RUVBL2 UCHL5 UCHL5 SMARCA4 SMARCA4 SIRT6 SIRT6 BCL7B BCL7B PNKP PNKP EPC2 EPC2 PCNA PCNA PHF10 PHF10 ACTR2 ACTR2 UBE2V2 UBE2V2 RIF1 RIF1 TFPT TFPT BRCC3 BRCC3 ENSANAP00000014459 ENSANAP00000014459 ENSANAP00000014564 ENSANAP00000014564 ARID1A ARID1A DDX11 DDX11 SMARCD1 SMARCD1 ING3 ING3 WDR48 WDR48 WAS WAS MFSD11 MFSD11 ENSANAP00000000987 ENSANAP00000000987 SLF1 SLF1 ENSANAP00000002528 ENSANAP00000002528 SMARCD3 SMARCD3 ENSANAP00000003268 ENSANAP00000003268 ENSANAP00000003886 ENSANAP00000003886 BRCA1 BRCA1 EYA2 EYA2 ERCC8 ERCC8 ENSANAP00000005053 ENSANAP00000005053 RBBP8 RBBP8 NFRKB NFRKB FUS FUS BCL7C BCL7C LOC105715186 LOC105715186 RAD51AP1 RAD51AP1 ENSANAP00000009102 ENSANAP00000009102
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPIRE2Spire type actin nucleation factor 2. (587 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (238 aa)
KMT5CLysine methyltransferase 5C. (463 aa)
FANCBFA complementation group B. (858 aa)
PIAS4Protein inhibitor of activated STAT 4. (546 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1043 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (650 aa)
CCDC117Uncharacterized protein. (278 aa)
ENSANAP00000010942Ribosomal_S3_C domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (225 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
DPF1Double PHD fingers 1. (424 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (817 aa)
OOEPMOEP19 domain-containing protein. (149 aa)
DPF3Double PHD fingers 3. (412 aa)
UIMC1Ubiquitin interaction motif containing 1. (736 aa)
MBTD1Mbt domain containing 1. (604 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (572 aa)
INO80BPAPA-1 domain-containing protein. (356 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1587 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
EPC1Enhancer of polycomb homolog. (835 aa)
TRIM28Tripartite motif containing 28. (834 aa)
ENSANAP00000019133BZIP domain-containing protein. (163 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1495 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (259 aa)
LOC105705170EP400_N domain-containing protein. (440 aa)
FAM168AFamily with sequence similarity 168 member A. (244 aa)
MEAF6MYST/Esa1 associated factor 6. (207 aa)
ACTL6AActin like 6A; Belongs to the actin family. (363 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (210 aa)
MCRS1Microspherule protein 1. (475 aa)
BABAM1BRISC and BRCA1 A complex member 1. (329 aa)
LOC110569273Uncharacterized protein. (471 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
ENSANAP00000021522Lyase_1 domain-containing protein. (165 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4076 aa)
KHDC3LMOEP19 domain-containing protein. (217 aa)
SPIDRScaffold protein involved in DNA repair. (947 aa)
NPAS2Neuronal PAS domain protein 2. (871 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
ENSANAP00000023031Uncharacterized protein. (999 aa)
POGZPogo transposable element derived with ZNF domain. (1410 aa)
ENSANAP00000023178MOEP19 domain-containing protein. (87 aa)
KMT5BLysine methyltransferase 5B. (883 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (224 aa)
INO80DINO80 complex subunit D. (1027 aa)
BABAM2BRISC and BRCA1 A complex member 2. (391 aa)
LOC105721409HMG box domain-containing protein. (390 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1106 aa)
ZCWPW1Zinc finger CW-type and PWWP domain containing 1. (646 aa)
DHX9DExH-box helicase 9. (1270 aa)
MRNIPMRN complex interacting protein. (331 aa)
ENSANAP00000026808HMG box domain-containing protein. (397 aa)
ARID1BAT-rich interaction domain 1B. (1539 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
CEBPGBZIP domain-containing protein. (150 aa)
BRD8Bromodomain containing 8. (1235 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1106 aa)
ENSANAP00000027633SWIB domain-containing protein. (547 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (569 aa)
ENSANAP00000028020Uncharacterized protein; Belongs to the universal ribosomal protein uS3 family. (207 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (467 aa)
ENSANAP00000028165Uncharacterized protein. (229 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3860 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (429 aa)
EP400E1A binding protein p400. (3067 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (394 aa)
SHLD2Shieldin complex subunit 2. (934 aa)
ACTL6BActin like 6B; Belongs to the actin family. (443 aa)
INO80INO80 complex ATPase subunit. (1557 aa)
SMARCE1HMG box domain-containing protein. (414 aa)
VPS72Vacuolar protein sorting 72 homolog. (325 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
HDGFL2HDGF like 2. (672 aa)
PARP1Poly [ADP-ribose] polymerase. (1040 aa)
YEATS4YEATS domain containing 4. (227 aa)
HELQHelicase, POLQ like. (1101 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1240 aa)
PBRM1Polybromo 1. (1725 aa)
FHFumarate hydratase. (510 aa)
ENSANAP00000034595SAE2 domain-containing protein. (96 aa)
TIMELESSTimeless circadian regulator. (1181 aa)
SPIRE1Spire type actin nucleation factor 1. (499 aa)
HDAC10Histone deacetylase 10. (669 aa)
DPF2Double PHD fingers 2. (405 aa)
FOXM1Forkhead box M1. (781 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (773 aa)
ENSANAP00000036359MOEP19 domain-containing protein. (223 aa)
SIRT1Sirtuin 1. (751 aa)
ENSANAP00000037068Uncharacterized protein. (150 aa)
EGFREpidermal growth factor receptor. (705 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (369 aa)
INO80EINO80 complex subunit E. (244 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (477 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (362 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1728 aa)
SIRT6Sirtuin 6. (354 aa)
BCL7BBAF chromatin remodeling complex subunit BCL7B. (202 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
EPC2Enhancer of polycomb homolog. (807 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PHF10PHD finger protein 10. (499 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (143 aa)
RIF1Replication timing regulatory factor 1. (2468 aa)
TFPTTCF3 fusion partner. (253 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (209 aa)
ENSANAP00000014459HMG box domain-containing protein. (164 aa)
ENSANAP00000014564Uncharacterized protein. (120 aa)
ARID1AAT-rich interaction domain 1A. (2018 aa)
DDX11DEAD/H-box helicase 11. (925 aa)
SMARCD1SWIB domain-containing protein. (515 aa)
ING3Inhibitor of growth protein. (418 aa)
WDR48WD repeat domain 48. (677 aa)
WASWASP actin nucleation promoting factor. (544 aa)
MFSD11Major facilitator superfamily domain containing 11. (294 aa)
ENSANAP00000000987HMG box domain-containing protein. (391 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1039 aa)
ENSANAP00000002528DUF4502 domain-containing protein. (214 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
ENSANAP00000003268MOEP19 domain-containing protein. (120 aa)
ENSANAP00000003886KH type-2 domain-containing protein. (102 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1827 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (543 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
ENSANAP00000005053Uncharacterized protein. (75 aa)
RBBP8Uncharacterized protein. (898 aa)
NFRKBNuclear factor related to kappaB binding protein. (1324 aa)
FUSUncharacterized protein. (525 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (242 aa)
LOC105715186HMG box domain-containing protein. (371 aa)
RAD51AP1RAD51 associated protein 1. (350 aa)
ENSANAP00000009102KH type-2 domain-containing protein. (208 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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