(43 nodes) Positive regulation of Notch signaling pathway network (Aotus nancymaae)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	GATA5	GATA binding protein 5. (378 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (260 aa)
	STAT3	Signal transducer and activator of transcription. (805 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1248 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	ROBO2	Roundabout guidance receptor 2. (1439 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	IL6ST	Interleukin 6 signal transducer. (922 aa)
	POGLUT1	Protein O-glucosyltransferase 1. (391 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (747 aa)
	ROBO1	Roundabout guidance receptor 1. (1684 aa)
	ENSANAP00000009960	PID domain-containing protein. (188 aa)
	AAK1	AP2 associated kinase 1. (968 aa)
	FKBP14	Peptidylprolyl isomerase. (176 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase. (321 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	ENSANAP00000011886	Uncharacterized protein. (350 aa)
	NOTCH1	Notch receptor 1. (2527 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase. (364 aa)
	TSPAN14	Tetraspanin. (312 aa)
	CNTN6	Contactin 6. (1029 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (718 aa)
	NEPRO	Nucleolus and neural progenitor protein. (559 aa)
	CCN3	Cellular communication network factor 3. (357 aa)
	TM2D2	TM2 domain containing 2. (214 aa)
	YAP1	Uncharacterized protein. (508 aa)
	SLC35C2	Solute carrier family 35 member C2. (391 aa)
	BMP2K	BMP2 inducible kinase. (1132 aa)
	ENSANAP00000039808	Uncharacterized protein. (156 aa)
	RFNG	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (319 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ENHO	Energy homeostasis associated. (76 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (230 aa)
	EPN2	Epsin 2. (641 aa)
	GSX2	GS homeobox 2. (304 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1066 aa)
	TM2D3	TM2 domain containing 3. (247 aa)
	TSPAN5	Tetraspanin. (268 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	DLL1	ENSANAP00000002350	ENSANAP00000009216	Achaete-scute family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.404
ASCL1	GSX2	ENSANAP00000002350	ENSANAP00000002977	Achaete-scute family bHLH transcription factor 1.	GS homeobox 2.	0.580
CCN3	NOTCH1	ENSANAP00000020603	ENSANAP00000014724	Cellular communication network factor 3.	Notch receptor 1.	0.431
DLL1	ASCL1	ENSANAP00000009216	ENSANAP00000002350	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Achaete-scute family bHLH transcription factor 1.	0.404
DLL1	DLL4	ENSANAP00000009216	ENSANAP00000018464	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.882
DLL1	JAG1	ENSANAP00000009216	ENSANAP00000011823	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.608
DLL1	JAG2	ENSANAP00000009216	ENSANAP00000032462	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.477
DLL1	LFNG	ENSANAP00000009216	ENSANAP00000014853	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.565
DLL1	NOTCH1	ENSANAP00000009216	ENSANAP00000014724	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.985
DLL4	DLL1	ENSANAP00000018464	ENSANAP00000009216	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.882
DLL4	JAG1	ENSANAP00000018464	ENSANAP00000011823	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.514
DLL4	JAG2	ENSANAP00000018464	ENSANAP00000032462	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.608
DLL4	NOTCH1	ENSANAP00000018464	ENSANAP00000014724	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.983
ENSANAP00000009960	PDCD10	ENSANAP00000009960	ENSANAP00000008806	PID domain-containing protein.	Programmed cell death 10.	0.435
ENSANAP00000011886	SRC	ENSANAP00000011886	ENSANAP00000031666	Uncharacterized protein.	Tyrosine-protein kinase.	0.473
ENSANAP00000011886	TP63	ENSANAP00000011886	ENSANAP00000036137	Uncharacterized protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.675
ENSANAP00000039808	SRC	ENSANAP00000039808	ENSANAP00000031666	Uncharacterized protein.	Tyrosine-protein kinase.	0.473
ENSANAP00000039808	TP63	ENSANAP00000039808	ENSANAP00000036137	Uncharacterized protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.675
EPN2	TP63	ENSANAP00000002687	ENSANAP00000036137	Epsin 2.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.493
FKBP14	POGLUT1	ENSANAP00000010448	ENSANAP00000008118	Peptidylprolyl isomerase.	Protein O-glucosyltransferase 1.	0.579