STRINGSTRING
ADA ADA SMAD3 SMAD3 EPHB3 EPHB3 SHOX2 SHOX2 FZD5 FZD5 RBPMS2 RBPMS2 FGF9 FGF9 HIF1A HIF1A ASCL1 ASCL1 ENSANAP00000002382 ENSANAP00000002382 SOX11 SOX11 ZIC3 ZIC3 SMO SMO ENSANAP00000005171 ENSANAP00000005171 SFRP2 SFRP2 CCKBR CCKBR EDNRB EDNRB IL6ST IL6ST ALDH1A2 ALDH1A2 NKX2-3 NKX2-3 TCF21 TCF21 SFRP1 SFRP1 LOC105730226 LOC105730226 EPB41L5 EPB41L5 EXT1 EXT1 RB1 RB1 ENSANAP00000010133 ENSANAP00000010133 TIGAR TIGAR WNT11 WNT11 GATA4 GATA4 SOX9 SOX9 NIPBL NIPBL PDGFC PDGFC ENSANAP00000011886 ENSANAP00000011886 LOC105732456 LOC105732456 NODAL NODAL ENSANAP00000012350 ENSANAP00000012350 COL3A1 COL3A1 PYY PYY ENSANAP00000012831 ENSANAP00000012831 VPS52 VPS52 PTK6 PTK6 PKD1 PKD1 C1GALT1 C1GALT1 NOTCH1 NOTCH1 YIPF6 YIPF6 SIX2 SIX2 PKDCC PKDCC TGFBR2 TGFBR2 CRKL CRKL NKX2-6 NKX2-6 SALL1 SALL1 HOXA13 HOXA13 CCDC103 CCDC103 SCT SCT ALX4 ALX4 SAV1 SAV1 SPDEF SPDEF HMGCS2 HMGCS2 MEGF8 MEGF8 AHI1 AHI1 ENSANAP00000022860 ENSANAP00000022860 TGFB3 TGFB3 FOXF2 FOXF2 GATA6 GATA6 MIXL1 MIXL1 HOXD13 HOXD13 YAP1 YAP1 ASS1 ASS1 LGR4 LGR4 CBFA2T2 CBFA2T2 ENSANAP00000024647 ENSANAP00000024647 WNT5A WNT5A KLF5 KLF5 KIT KIT FOXE1 FOXE1 PRDM1 PRDM1 ENSANAP00000026571 ENSANAP00000026571 NKX2-2 NKX2-2 SMAD2 SMAD2 NKX3-2 NKX3-2 FGFR2 FGFR2 ENSANAP00000028124 ENSANAP00000028124 GATA5 GATA5 KCNQ1 KCNQ1 ENSANAP00000029410 ENSANAP00000029410 LOC105718653 LOC105718653 TGFB2 TGFB2 TNF TNF CLDN18 CLDN18 BCL2 BCL2 GLI3 GLI3 COBL COBL PDX1 PDX1 SRC SRC FOXF1 FOXF1 CCDC39 CCDC39 CTNNB1 CTNNB1 CXCL8 CXCL8 AGR2 AGR2 ENSANAP00000033572 ENSANAP00000033572 ACVR2B ACVR2B HOXA5 HOXA5 GLI2 GLI2 CCDC40 CCDC40 SOX17 SOX17 DACT1 DACT1 STRA6 STRA6 SOX10 SOX10 TP63 TP63 ID2 ID2 TGFB1 TGFB1 ENSANAP00000036751 ENSANAP00000036751 DNAAF1 DNAAF1 BMP4 BMP4 CLMP CLMP RARB RARB GLI1 GLI1 IFT172 IFT172 TYMS TYMS HLX HLX CPS1 CPS1 TBX2 TBX2 ENSANAP00000039808 ENSANAP00000039808 MYOCD MYOCD CHD8 CHD8 BBS7 BBS7 FGF10 FGF10 OTC OTC IHH IHH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAAdenosine deaminase. (363 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
EPHB3EPH receptor B3. (1000 aa)
SHOX2Short stature homeobox 2. (355 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (205 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (230 aa)
ENSANAP00000002382Uncharacterized protein. (226 aa)
SOX11Transcription factor SOX. (449 aa)
ZIC3Zic family member 3. (467 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
ENSANAP00000005171Uncharacterized protein. (400 aa)
SFRP2Secreted frizzled related protein 2. (296 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (447 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
IL6STInterleukin 6 signal transducer. (922 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (539 aa)
NKX2-3NK2 homeobox 3. (363 aa)
TCF21Transcription factor 21. (179 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
LOC105730226Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
RB1RB transcriptional corepressor 1. (925 aa)
ENSANAP00000010133Uncharacterized protein. (104 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
GATA4GATA binding protein 4. (443 aa)
SOX9SRY-box transcription factor 9. (505 aa)
NIPBLNipped-B protein. (2804 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ENSANAP00000011886Uncharacterized protein. (350 aa)
LOC105732456Uncharacterized protein. (983 aa)
NODALNodal growth differentiation factor. (347 aa)
ENSANAP00000012350Uncharacterized protein. (408 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
PYYPeptide YY. (97 aa)
ENSANAP00000012831Uncharacterized protein. (470 aa)
VPS52VPS52 subunit of GARP complex. (723 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4274 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
NOTCH1Notch receptor 1. (2527 aa)
YIPF6Protein YIPF. (236 aa)
SIX2SIX homeobox 2. (293 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (479 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
NKX2-6NK2 homeobox 6. (301 aa)
SALL1Spalt like transcription factor 1. (1322 aa)
HOXA13Homeobox A13. (363 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
SCTSecretin. (114 aa)
ALX4ALX homeobox 4. (402 aa)
SAV1Salvador family WW domain containing protein 1. (413 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (511 aa)
MEGF8Multiple EGF like domains 8. (2858 aa)
AHI1Abelson helper integration site 1. (1207 aa)
ENSANAP00000022860Uncharacterized protein. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FOXF2Forkhead box F2. (415 aa)
GATA6GATA binding protein 6. (585 aa)
MIXL1Mix paired-like homeobox. (235 aa)
HOXD13Homeobox D13. (344 aa)
YAP1Uncharacterized protein. (508 aa)
ASS1Uncharacterized protein. (412 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (927 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (600 aa)
ENSANAP00000024647HH_signal domain-containing protein. (127 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KLF5Uncharacterized protein. (457 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
FOXE1Forkhead box E1. (363 aa)
PRDM1PR/SET domain 1. (825 aa)
ENSANAP00000026571Uncharacterized protein. (128 aa)
NKX2-2NK2 homeobox 2. (273 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NKX3-2NK3 homeobox 2. (333 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ENSANAP00000028124Uncharacterized protein. (438 aa)
GATA5GATA binding protein 5. (378 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
ENSANAP00000029410Protein kinase domain-containing protein. (959 aa)
LOC105718653Uncharacterized protein; Belongs to the peptidase S8 family. (913 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
GLI3GLI family zinc finger 3. (1578 aa)
COBLCordon-bleu WH2 repeat protein. (1294 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
SRCTyrosine-protein kinase. (542 aa)
FOXF1Forkhead box F1. (380 aa)
CCDC39Uncharacterized protein. (488 aa)
CTNNB1Catenin beta 1. (781 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (189 aa)
ENSANAP00000033572Thymidylat_synt domain-containing protein. (153 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
HOXA5Homeobox A5. (270 aa)
GLI2GLI family zinc finger 2. (1588 aa)
CCDC40Coiled-coil domain containing 40. (975 aa)
SOX17SRY-box transcription factor 17. (410 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (836 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
SOX10SRY-box transcription factor 10. (466 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
ENSANAP00000036751Uncharacterized protein. (101 aa)
DNAAF1Dynein assembly factor 1, axonemal. (693 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CLMPCXADR like membrane protein. (384 aa)
RARBRetinoic acid receptor beta. (448 aa)
GLI1GLI family zinc finger 1. (1105 aa)
IFT172Uncharacterized protein. (1585 aa)
TYMSThymidylat_synt domain-containing protein. (313 aa)
HLXH2.0 like homeobox. (492 aa)
CPS1Carbamoyl-phosphate synthase 1. (1500 aa)
TBX2T-box transcription factor 2. (713 aa)
ENSANAP00000039808Uncharacterized protein. (156 aa)
MYOCDMyocardin. (984 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2589 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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