STRINGSTRING
STK4 STK4 ISL1 ISL1 CDKN2B CDKN2B GAS1 GAS1 MTSS1 MTSS1 CAV2 CAV2 ATP5F1A ATP5F1A FLCN FLCN SFRP2 SFRP2 SNAI2 SNAI2 IFT57 IFT57 TINF2 TINF2 SPARC SPARC SFRP1 SFRP1 IRF6 IRF6 TNMD TNMD TRIM24 TRIM24 CASK CASK RB1 RB1 DAB2IP DAB2IP PDCD10 PDCD10 RAP1GAP RAP1GAP ROBO1 ROBO1 SOX9 SOX9 LIMS2 LIMS2 MEN1 MEN1 NKX2-8 NKX2-8 SULF1 SULF1 ENG ENG TGFBR1 TGFBR1 EFNB2 EFNB2 CPB2 CPB2 ENSANAP00000012348 ENSANAP00000012348 ENSANAP00000012831 ENSANAP00000012831 RIDA RIDA ENSANAP00000013693 ENSANAP00000013693 ENSANAP00000013961 ENSANAP00000013961 CDK6 CDK6 NOTCH1 NOTCH1 MMRN2 MMRN2 WDR77 WDR77 IFT74 IFT74 DLG1 DLG1 B4GALT1 B4GALT1 BRCA2 BRCA2 MCC MCC RGCC RGCC NLRC3 NLRC3 ACVRL1 ACVRL1 MARVELD3 MARVELD3 DLL4 DLL4 LOC105725023 LOC105725023 GDF5 GDF5 KDF1 KDF1 IFT80 IFT80 FLT1 FLT1 STAT1 STAT1 CAV1 CAV1 SAV1 SAV1 VDR VDR STK3 STK3 DUSP10 DUSP10 APOE APOE IL12A IL12A WDR13 WDR13 ENSANAP00000022860 ENSANAP00000022860 SYNJ2BP SYNJ2BP TBC1D31 TBC1D31 ATP5IF1 ATP5IF1 PTCH1 PTCH1 EAF2 EAF2 NFIB NFIB ALOX5 ALOX5 GHRL GHRL RUNX3 RUNX3 GDF2 GDF2 WNT5A WNT5A INTU INTU HPN HPN STK11 STK11 DAB2 DAB2 ATOH8 ATOH8 MED1 MED1 MEF2C MEF2C CD109 CD109 NKX3-1 NKX3-1 ATF2 ATF2 NUPR1 NUPR1 NF1 NF1 IFT172 IFT172 BMP4 BMP4 APOH APOH ZEB1 ZEB1 TGFB1 TGFB1 CDKN1B CDKN1B PPARD PPARD PRL PRL PTPRM PTPRM ENSANAP00000033932 ENSANAP00000033932 KRIT1 KRIT1 IL26 IL26 KRT4 KRT4 PAX6 PAX6 PDX1 PDX1 VASH1 VASH1 PTEN PTEN AIMP1 AIMP1 FBXW7 FBXW7 IFT52 IFT52 XDH XDH AR AR TNF TNF B2M B2M TGFB2 TGFB2 SLURP1 SLURP1 EREG EREG PTPRK PTPRK AQP11 AQP11 FGFR2 FGFR2 WNT10B WNT10B PHOX2B PHOX2B DRD2 DRD2 OVOL1 OVOL1 PEX2 PEX2 GATA3 GATA3 CNMD CNMD CDC73 CDC73 SERPINF1 SERPINF1 TGFBR3 TGFBR3 A4GNT A4GNT MAGED1 MAGED1 THBS1 THBS1 SFN SFN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
ISL1Uncharacterized protein. (349 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
GAS1Growth arrest specific 1. (342 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (460 aa)
FLCNFolliculin. (579 aa)
SFRP2Secreted frizzled related protein 2. (296 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
IFT57Intraflagellar transport 57. (418 aa)
TINF2TERF1 interacting nuclear factor 2. (449 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
IRF6Interferon regulatory factor 6. (462 aa)
TNMDTenomodulin. (317 aa)
TRIM24Tripartite motif containing 24. (1051 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
RB1RB transcriptional corepressor 1. (925 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
PDCD10Programmed cell death 10. (212 aa)
RAP1GAPRAP1 GTPase activating protein. (751 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
SOX9SRY-box transcription factor 9. (505 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (373 aa)
MEN1Menin 1. (610 aa)
NKX2-8NK2 homeobox 8. (236 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
ENGEndoglin. (440 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
CPB2Carboxypeptidase B2. (423 aa)
ENSANAP00000012348Uncharacterized protein. (117 aa)
ENSANAP00000012831Uncharacterized protein. (470 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
ENSANAP00000013693Uncharacterized protein. (110 aa)
ENSANAP00000013961Uncharacterized protein. (131 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
NOTCH1Notch receptor 1. (2527 aa)
MMRN2Multimerin 2. (953 aa)
WDR77WD repeat domain 77. (342 aa)
IFT74Intraflagellar transport 74. (574 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (400 aa)
BRCA2BRCA2 DNA repair associated. (3404 aa)
MCCMCC regulator of WNT signaling pathway. (1015 aa)
RGCCRegulator of cell cycle. (163 aa)
NLRC3NLR family CARD domain containing 3. (1080 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MARVELD3MARVEL domain containing 3. (417 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (718 aa)
LOC105725023Uncharacterized protein. (336 aa)
GDF5Growth differentiation factor 5. (501 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
IFT80Intraflagellar transport 80. (778 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
STAT1Signal transducer and activator of transcription. (781 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
SAV1Salvador family WW domain containing protein 1. (413 aa)
VDRVitamin D receptor. (400 aa)
STK3Serine/threonine kinase 3. (523 aa)
DUSP10Dual specificity phosphatase 10. (494 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (281 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
WDR13WD repeat domain 13. (485 aa)
ENSANAP00000022860Uncharacterized protein. (390 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
TBC1D31TBC1 domain family member 31. (1053 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
PTCH1Patched 1. (1453 aa)
EAF2ELL associated factor 2. (261 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
ALOX5Arachidonate 5-lipoxygenase. (699 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (429 aa)
GDF2Growth differentiation factor 2. (429 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
INTUInturned planar cell polarity protein. (932 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
DAB2DAB adaptor protein 2. (552 aa)
ATOH8Atonal bHLH transcription factor 8. (351 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
MEF2CMyocyte enhancer factor 2C. (490 aa)
CD109CD109 molecule. (1446 aa)
NKX3-1NK3 homeobox 1. (222 aa)
ATF2Activating transcription factor 2. (287 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
NF1Neurofibromin 1. (2772 aa)
IFT172Uncharacterized protein. (1585 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
APOHApolipoprotein H. (372 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (205 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
PRLProlactin. (228 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1576 aa)
ENSANAP00000033932Uncharacterized protein. (576 aa)
KRIT1Uncharacterized protein. (731 aa)
IL26Interleukin 26. (171 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (532 aa)
PAX6Paired box 6. (475 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
VASH1Vasohibin 1. (365 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (248 aa)
FBXW7F-box and WD repeat domain containing 7. (732 aa)
IFT52Intraflagellar transport 52. (436 aa)
XDHXanthine dehydrogenase. (1333 aa)
ARAndrogen receptor. (887 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (130 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (104 aa)
EREGEpiregulin. (161 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1485 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PHOX2BPaired like homeobox 2B. (301 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
GATA3GATA binding protein 3. (409 aa)
CNMDChondromodulin. (334 aa)
CDC73Cell division cycle 73. (557 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (390 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (344 aa)
MAGED1MAGE family member D1. (778 aa)
THBS1Thrombospondin 1. (1173 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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