(43 nodes) B cell receptor signaling pathway network (Aotus nancymaae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IGLL1	Immunoglobulin lambda like polypeptide 1. (213 aa)
	RFTN1	Raftlin, lipid raft linker 1. (542 aa)
	IGHV3-72	Immunoglobulin heavy variable 3-72. (101 aa)
	ENSANAP00000004416	Ig-like domain-containing protein. (129 aa)
	PTPRC	Uncharacterized protein. (1299 aa)
	LYN	LYN proto-oncogene, Src family tyrosine kinase. (498 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	CD79B	CD79b molecule. (230 aa)
	BLK	Tyrosine-protein kinase. (500 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	ENSANAP00000014481	Ig-like domain-containing protein. (184 aa)
	NCKAP1L	NCK associated protein 1 like. (1134 aa)
	MAPK1	Mitogen-activated protein kinase. (376 aa)
	ENSANAP00000015586	PH domain-containing protein. (173 aa)
	BAX	BCL2 associated X, apoptosis regulator. (193 aa)
	PLEKHA1	Uncharacterized protein. (404 aa)
	LIME1	Uncharacterized protein. (291 aa)
	BLNK	B cell linker. (456 aa)
	ITK	Tyrosine-protein kinase. (620 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (875 aa)
	MORN5	MORN repeat containing 5. (162 aa)
	BMX	Tyrosine-protein kinase. (679 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	NFAM1	NFAT activating protein with ITAM motif 1. (270 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
	LAT2	Linker for activation of T cells family member 2. (243 aa)
	ENSANAP00000028003	SH3 domain-containing protein. (787 aa)
	BCL2	BCL2 apoptosis regulator. (240 aa)
	ENSANAP00000032255	Uncharacterized protein. (316 aa)
	CD38	CD38 molecule. (306 aa)
	CD79A	CD79a molecule. (225 aa)
	KLHL6	Kelch like family member 6. (621 aa)
	NFATC2	Nuclear factor of activated T cells 2. (923 aa)
	CD19	CD19 molecule. (565 aa)
	MS4A1	Membrane spanning 4-domains A1. (295 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	TEC	Tyrosine-protein kinase. (635 aa)
	BCAR1	SH3 domain-containing protein. (920 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (849 aa)
	MEF2C	Myocyte enhancer factor 2C. (490 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	MAPK1	ENSANAP00000024509	ENSANAP00000014877	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.577
ABL1	MEF2C	ENSANAP00000024509	ENSANAP00000040463	Tyrosine-protein kinase.	Myocyte enhancer factor 2C.	0.474
ABL1	NCKAP1L	ENSANAP00000024509	ENSANAP00000014508	Tyrosine-protein kinase.	NCK associated protein 1 like.	0.668
BANK1	BLK	ENSANAP00000039748	ENSANAP00000014151	B cell scaffold protein with ankyrin repeats 1.	Tyrosine-protein kinase.	0.588
BANK1	CD19	ENSANAP00000039748	ENSANAP00000035401	B cell scaffold protein with ankyrin repeats 1.	CD19 molecule.	0.705
BANK1	LYN	ENSANAP00000039748	ENSANAP00000006027	B cell scaffold protein with ankyrin repeats 1.	LYN proto-oncogene, Src family tyrosine kinase.	0.477
BANK1	MS4A1	ENSANAP00000039748	ENSANAP00000035895	B cell scaffold protein with ankyrin repeats 1.	Membrane spanning 4-domains A1.	0.696
BANK1	PIK3CD	ENSANAP00000039748	ENSANAP00000027459	B cell scaffold protein with ankyrin repeats 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.452
BAX	BCL2	ENSANAP00000017127	ENSANAP00000030335	BCL2 associated X, apoptosis regulator.	BCL2 apoptosis regulator.	0.970
BCAR1	LYN	ENSANAP00000037819	ENSANAP00000006027	SH3 domain-containing protein.	LYN proto-oncogene, Src family tyrosine kinase.	0.624
BCAR1	NCKAP1L	ENSANAP00000037819	ENSANAP00000014508	SH3 domain-containing protein.	NCK associated protein 1 like.	0.500
BCL2	BAX	ENSANAP00000030335	ENSANAP00000017127	BCL2 apoptosis regulator.	BCL2 associated X, apoptosis regulator.	0.970
BCL2	MAPK1	ENSANAP00000030335	ENSANAP00000014877	BCL2 apoptosis regulator.	Mitogen-activated protein kinase.	0.827
BLK	BANK1	ENSANAP00000014151	ENSANAP00000039748	Tyrosine-protein kinase.	B cell scaffold protein with ankyrin repeats 1.	0.588
BLK	BLNK	ENSANAP00000014151	ENSANAP00000018724	Tyrosine-protein kinase.	B cell linker.	0.479
BLK	CD19	ENSANAP00000014151	ENSANAP00000035401	Tyrosine-protein kinase.	CD19 molecule.	0.883
BLK	CD79A	ENSANAP00000014151	ENSANAP00000034297	Tyrosine-protein kinase.	CD79a molecule.	0.868
BLK	CD79B	ENSANAP00000014151	ENSANAP00000014134	Tyrosine-protein kinase.	CD79b molecule.	0.842
BLK	MAPK1	ENSANAP00000014151	ENSANAP00000014877	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.456
BLK	MS4A1	ENSANAP00000014151	ENSANAP00000035895	Tyrosine-protein kinase.	Membrane spanning 4-domains A1.	0.590