(37 nodes) Regulation of cardiac muscle cell proliferation network (Aotus nancymaae)

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Your Input:
	KCNK2	Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (860 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1206 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
	ENSANAP00000011886	Uncharacterized protein. (350 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
	NOTCH1	Notch receptor 1. (2527 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	SAV1	Salvador family WW domain containing protein 1. (413 aa)
	TBX20	T-box transcription factor 20. (447 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	GATA6	GATA binding protein 6. (585 aa)
	YAP1	Uncharacterized protein. (508 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1019 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (462 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (635 aa)
	MEIS2	Meis homeobox 2. (473 aa)
	NRG1	Neuregulin 1. (713 aa)
	FGFR2	Fibroblast growth factor receptor. (840 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	GLI1	GLI family zinc finger 1. (1105 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (250 aa)
	TBX2	T-box transcription factor 2. (713 aa)
	ENSANAP00000039808	Uncharacterized protein. (156 aa)
	MEF2C	Myocyte enhancer factor 2C. (490 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	VGLL4	Vestigial like family member 4. (296 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	BMPR1A	ENSANAP00000022879	ENSANAP00000009783	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.632
BMP10	NOG	ENSANAP00000022879	ENSANAP00000000648	Bone morphogenetic protein 10.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.412
BMP10	TGFBR1	ENSANAP00000022879	ENSANAP00000011578	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.632
BMP10	TGFBR2	ENSANAP00000022879	ENSANAP00000017484	Bone morphogenetic protein 10.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.417
BMPR1A	BMP10	ENSANAP00000009783	ENSANAP00000022879	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.632
BMPR1A	NOG	ENSANAP00000009783	ENSANAP00000000648	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.491
BMPR1A	PTEN	ENSANAP00000009783	ENSANAP00000031376	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.405
BMPR1A	TGFBR2	ENSANAP00000009783	ENSANAP00000017484	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.745
BMPR1A	TGFBR3	ENSANAP00000009783	ENSANAP00000001016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta receptor 3.	0.435
ENSANAP00000011886	ERBB4	ENSANAP00000011886	ENSANAP00000032696	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.817
ENSANAP00000011886	RUNX1	ENSANAP00000011886	ENSANAP00000024288	Uncharacterized protein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.732
ENSANAP00000011886	SAV1	ENSANAP00000011886	ENSANAP00000020982	Uncharacterized protein.	Salvador family WW domain containing protein 1.	0.705
ENSANAP00000011886	TBX5	ENSANAP00000011886	ENSANAP00000001584	Uncharacterized protein.	T-box transcription factor 5.	0.718
ENSANAP00000011886	TGFBR1	ENSANAP00000011886	ENSANAP00000011578	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.859
ENSANAP00000011886	TGFBR2	ENSANAP00000011886	ENSANAP00000017484	Uncharacterized protein.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.853
ENSANAP00000011886	TP73	ENSANAP00000011886	ENSANAP00000026902	Uncharacterized protein.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.942
ENSANAP00000011886	VGLL4	ENSANAP00000011886	ENSANAP00000041694	Uncharacterized protein.	Vestigial like family member 4.	0.738
ENSANAP00000039808	ERBB4	ENSANAP00000039808	ENSANAP00000032696	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.817
ENSANAP00000039808	RUNX1	ENSANAP00000039808	ENSANAP00000024288	Uncharacterized protein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.732
ENSANAP00000039808	SAV1	ENSANAP00000039808	ENSANAP00000020982	Uncharacterized protein.	Salvador family WW domain containing protein 1.	0.705