STRINGSTRING
DKK1 DKK1 WNT9A WNT9A WNT16 WNT16 SDC1 SDC1 WNT10B WNT10B WNT6 WNT6 PLPP3 PLPP3 STK4 STK4 WNT8A WNT8A RSPO3 RSPO3 ENSANAP00000011886 ENSANAP00000011886 PPP1CA PPP1CA CBY1 CBY1 PYGO2 PYGO2 SOSTDC1 SOSTDC1 SOX9 SOX9 WNT11 WNT11 FZD5 FZD5 SIAH2 SIAH2 SIAH1 SIAH1 FZD7 FZD7 FGF9 FGF9 ISL1 ISL1 RYK RYK FZD10 FZD10 LOC105714727 LOC105714727 ENSANAP00000004343 ENSANAP00000004343 SFRP5 SFRP5 LOC105729166 LOC105729166 FZD9 FZD9 FZD4 FZD4 WNT2B WNT2B DVL3 DVL3 SFRP2 SFRP2 AXIN1 AXIN1 FZD2 FZD2 EDNRB EDNRB WNT3A WNT3A TCF7L1 TCF7L1 SFRP1 SFRP1 EXT1 EXT1 BCL9 BCL9 ENSANAP00000019979 ENSANAP00000019979 WNT2 WNT2 EDA EDA LOC105725023 LOC105725023 WNT9B WNT9B WNT10A WNT10A GSK3B GSK3B WNT1 WNT1 SOST SOST DIXDC1 DIXDC1 PYGO1 PYGO1 BCL9L BCL9L ENSANAP00000039808 ENSANAP00000039808 TCF7L2 TCF7L2 DISC1 DISC1 LRRK2 LRRK2 ENSANAP00000038349 ENSANAP00000038349 RARG RARG LOC110567606 LOC110567606 CTDNEP1 CTDNEP1 RSPO2 RSPO2 DACT3 DACT3 LATS2 LATS2 GATA3 GATA3 LEF1 LEF1 EDN1 EDN1 ENSANAP00000024923 ENSANAP00000024923 WNT5A WNT5A WNT8B WNT8B EDNRA EDNRA WNT7B WNT7B LGR4 LGR4 DVL2 DVL2 YAP1 YAP1 DVL1 DVL1 FOXD1 FOXD1 SCYL2 SCYL2 STK3 STK3 SFRP4 SFRP4 CAV1 CAV1 JUP JUP CDH3 CDH3 KLF4 KLF4 RECK RECK FZD3 FZD3 TCF7 TCF7 CTNNB1 CTNNB1 ENSANAP00000032261 ENSANAP00000032261 HESX1 HESX1 LOC105717577 LOC105717577 PTEN PTEN WNT3 WNT3 WNT4 WNT4 WNT7A WNT7A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
RSPO3R-spondin 3. (277 aa)
ENSANAP00000011886Uncharacterized protein. (350 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
PYGO2Pygopus family PHD finger 2. (405 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
SOX9SRY-box transcription factor 9. (505 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ISL1Uncharacterized protein. (349 aa)
RYKReceptor like tyrosine kinase. (599 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
LOC105714727Homeobox domain-containing protein. (185 aa)
ENSANAP00000004343Protein kinase domain-containing protein. (331 aa)
SFRP5Secreted frizzled related protein 5. (320 aa)
LOC105729166Uncharacterized protein. (734 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
DVL3Dishevelled segment polarity protein 3. (724 aa)
SFRP2Secreted frizzled related protein 2. (296 aa)
AXIN1Axin 1. (867 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TCF7L1Transcription factor 7 like 1. (581 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BCL9BCL9 domain-containing protein. (1352 aa)
ENSANAP00000019979Fork-head domain-containing protein. (535 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (392 aa)
LOC105725023Uncharacterized protein. (336 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SOSTSclerostin. (213 aa)
DIXDC1DIX domain containing 1. (678 aa)
PYGO1Pygopus family PHD finger 1. (420 aa)
BCL9LBCL9 like. (1497 aa)
ENSANAP00000039808Uncharacterized protein. (156 aa)
TCF7L2Transcription factor 7 like 2. (618 aa)
DISC1DISC1 scaffold protein. (855 aa)
LRRK2Leucine rich repeat kinase 2. (2515 aa)
ENSANAP00000038349Homeobox domain-containing protein. (179 aa)
RARGRetinoic acid receptor gamma. (456 aa)
LOC110567606Homeobox domain-containing protein. (173 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (243 aa)
RSPO2R-spondin 2. (243 aa)
DACT3Dishevelled binding antagonist of beta catenin 3. (606 aa)
LATS2Non-specific serine/threonine protein kinase. (893 aa)
GATA3GATA binding protein 3. (409 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
EDN1Endothelin 1. (212 aa)
ENSANAP00000024923C2H2-type domain-containing protein. (95 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (274 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (927 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
YAP1Uncharacterized protein. (508 aa)
DVL1Dishevelled segment polarity protein 1. (750 aa)
FOXD1Forkhead box D1. (391 aa)
SCYL2SCY1 like pseudokinase 2. (929 aa)
STK3Serine/threonine kinase 3. (523 aa)
SFRP4Secreted frizzled related protein 4. (369 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
JUPUncharacterized protein. (745 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (828 aa)
KLF4Uncharacterized protein. (477 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (950 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
TCF7Transcription factor 7. (477 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSANAP00000032261Homeobox domain-containing protein. (188 aa)
HESX1Homeobox domain-containing protein. (185 aa)
LOC105717577E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (301 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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