STRINGSTRING
EYA1 EYA1 HOXA13 HOXA13 DLL4 DLL4 ACVRL1 ACVRL1 FOXC1 FOXC1 SUFU SUFU BMP4 BMP4 ENSANAP00000036248 ENSANAP00000036248 ARID2 ARID2 STRA6 STRA6 CHD7 CHD7 FOLR1 FOLR1 EFEMP2 EFEMP2 LDLR LDLR CITED2 CITED2 PDGFRB PDGFRB NF1 NF1 LUZP1 LUZP1 TBX2 TBX2 LRP1 LRP1 ZMIZ1 ZMIZ1 CNTRL CNTRL NKX3-1 NKX3-1 MYOCD MYOCD PLXND1 PLXND1 HECTD1 HECTD1 FOXC2 FOXC2 HOXA1 HOXA1 LOC105725485 LOC105725485 BMPR1A BMPR1A WNT11 WNT11 COMP COMP HEY2 HEY2 ENG ENG TGFBR1 TGFBR1 PRRX1 PRRX1 JAG1 JAG1 COL3A1 COL3A1 TBX1 TBX1 HAND2 HAND2 ADAMTS6 ADAMTS6 ADAMTS9 ADAMTS9 FOXH1 FOXH1 LEP LEP ADGRF5 ADGRF5 NOTCH1 NOTCH1 HPGD HPGD MYLK MYLK PRICKLE1 PRICKLE1 SLC2A10 SLC2A10 ENSANAP00000003798 ENSANAP00000003798 TFAP2B TFAP2B AP2B1 AP2B1 DCTN5 DCTN5 ANGPTL3 ANGPTL3 SRF SRF HEY1 HEY1 NOG NOG ROBO1 ROBO1 LOX LOX NOTCH3 NOTCH3 SMAD6 SMAD6 NRP1 NRP1 ACVR2B ACVR2B LOXL1 LOXL1 FOXF1 FOXF1 GLI3 GLI3 ENSANAP00000029929 ENSANAP00000029929 PDE2A PDE2A FKBP10 FKBP10 ROBO2 ROBO2 TGFB2 TGFB2 ENSANAP00000029309 ENSANAP00000029309 APOB APOB FGF8 FGF8 PRDM1 PRDM1 EDN1 EDN1 EGR2 EGR2 SEC24B SEC24B EDNRA EDNRA BMPR2 BMPR2 PKD2 PKD2 NDST1 NDST1 DDIT3 DDIT3 PROX1 PROX1 APOE APOE LOC105734067 LOC105734067 SMAD7 SMAD7 NPRL3 NPRL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
HOXA13Homeobox A13. (363 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (718 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
FOXC1Forkhead box C1. (539 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (520 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ENSANAP00000036248Uncharacterized protein. (136 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2983 aa)
FOLR1Folate receptor alpha. (255 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
LDLRLow density lipoprotein receptor. (786 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (250 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1110 aa)
NF1Neurofibromin 1. (2772 aa)
LUZP1Leucine zipper protein 1. (1062 aa)
TBX2T-box transcription factor 2. (713 aa)
LRP1LDL receptor related protein 1. (4544 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1066 aa)
CNTRLCentriolin. (2335 aa)
NKX3-1NK3 homeobox 1. (222 aa)
MYOCDMyocardin. (984 aa)
PLXND1Plexin D1. (1924 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
FOXC2Forkhead box C2. (489 aa)
HOXA1Homeobox A1. (334 aa)
LOC105725485AP complex subunit beta. (903 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENGEndoglin. (440 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
PRRX1Paired related homeobox 1. (245 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
TBX1T-box transcription factor 1. (468 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1117 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
FOXH1Fork-head domain-containing protein. (366 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1345 aa)
NOTCH1Notch receptor 1. (2527 aa)
HPGDUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
MYLKMyosin light chain kinase. (2022 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (539 aa)
ENSANAP00000003798Fork-head domain-containing protein. (343 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
AP2B1Uncharacterized protein. (928 aa)
DCTN5Dynactin subunit 5. (182 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
SRFSerum response factor. (509 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (376 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
LOXLysyl oxidase. (417 aa)
NOTCH3Notch receptor 3. (2320 aa)
SMAD6Mothers against decapentaplegic homolog. (494 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
LOXL1Lysyl oxidase like 1. (578 aa)
FOXF1Forkhead box F1. (380 aa)
GLI3GLI family zinc finger 3. (1578 aa)
ENSANAP00000029929Uncharacterized protein. (890 aa)
PDE2APhosphodiesterase. (941 aa)
FKBP10Peptidylprolyl isomerase. (595 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ENSANAP00000029309Fork-head domain-containing protein. (312 aa)
APOBApolipoprotein B. (3824 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
PRDM1PR/SET domain 1. (825 aa)
EDN1Endothelin 1. (212 aa)
EGR2Early growth response 2. (473 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1283 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (951 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (888 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
PROX1Prospero homeobox 1. (737 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (281 aa)
LOC105734067Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (237 aa)
SMAD7Mothers against decapentaplegic homolog. (489 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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