(44 nodes) Coronary vasculature development network (Aotus nancymaae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CNTRL	Centriolin. (2335 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (860 aa)
	SRF	Serum response factor. (509 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	DCTN5	Dynactin subunit 5. (182 aa)
	AP2B1	Uncharacterized protein. (928 aa)
	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif 6. (1117 aa)
	SMAD6	Mothers against decapentaplegic homolog. (494 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	LOC110567813	Uncharacterized protein. (432 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
	VEGFB	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
	TBX1	T-box transcription factor 1. (468 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (831 aa)
	NOTCH1	Notch receptor 1. (2527 aa)
	CPLANE1	Ciliogenesis and planar polarity effector 1. (3197 aa)
	MEGF8	Multiple EGF like domains 8. (2858 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1080 aa)
	GATA6	GATA binding protein 6. (585 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (888 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1283 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2520 aa)
	PRDM1	PR/SET domain 1. (825 aa)
	APELA	Apelin receptor early endogenous ligand. (54 aa)
	ENSANAP00000029929	Uncharacterized protein. (890 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	MMP21	Matrix metallopeptidase 21; Belongs to the peptidase M10A family. (564 aa)
	LOC105722663	Uncharacterized protein. (436 aa)
	ZBTB14	Uncharacterized protein. (449 aa)
	ARID2	AT-rich interaction domain 2. (1836 aa)
	ENSANAP00000036248	Uncharacterized protein. (136 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	DYNC2H1	Dynein cytoplasmic 2 heavy chain 1. (4254 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (260 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (520 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (447 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1110 aa)
	SGCD	Sarcoglycan delta. (290 aa)
	MYOCD	Myocardin. (984 aa)
	PLXND1	Plexin D1. (1924 aa)
	LOC105725485	AP complex subunit beta. (903 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APELA	APLNR	ENSANAP00000029522	ENSANAP00000001010	Apelin receptor early endogenous ligand.	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	0.927
APLNR	APELA	ENSANAP00000001010	ENSANAP00000029522	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor early endogenous ligand.	0.927
BMP4	GATA6	ENSANAP00000036913	ENSANAP00000022962	Bone morphogenetic protein 4.	GATA binding protein 6.	0.485
BMP4	SMAD6	ENSANAP00000036913	ENSANAP00000005203	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.665
BMP4	TBX5	ENSANAP00000036913	ENSANAP00000001584	Bone morphogenetic protein 4.	T-box transcription factor 5.	0.495
BMP4	TGFBR1	ENSANAP00000036913	ENSANAP00000011578	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.828
DCTN5	DYNC2H1	ENSANAP00000002612	ENSANAP00000037176	Dynactin subunit 5.	Dynein cytoplasmic 2 heavy chain 1.	0.473
DYNC2H1	DCTN5	ENSANAP00000037176	ENSANAP00000002612	Dynein cytoplasmic 2 heavy chain 1.	Dynactin subunit 5.	0.473
DYNC2H1	ENSANAP00000036248	ENSANAP00000037176	ENSANAP00000036248	Dynein cytoplasmic 2 heavy chain 1.	Uncharacterized protein.	0.473
ENSANAP00000036248	DYNC2H1	ENSANAP00000036248	ENSANAP00000037176	Uncharacterized protein.	Dynein cytoplasmic 2 heavy chain 1.	0.473
GATA6	BMP4	ENSANAP00000022962	ENSANAP00000036913	GATA binding protein 6.	Bone morphogenetic protein 4.	0.485
GATA6	HAND2	ENSANAP00000022962	ENSANAP00000013234	GATA binding protein 6.	Heart and neural crest derivatives expressed 2.	0.534
GATA6	MYOCD	ENSANAP00000022962	ENSANAP00000039968	GATA binding protein 6.	Myocardin.	0.432
GATA6	SRF	ENSANAP00000022962	ENSANAP00000001310	GATA binding protein 6.	Serum response factor.	0.672
GATA6	TBX5	ENSANAP00000022962	ENSANAP00000001584	GATA binding protein 6.	T-box transcription factor 5.	0.401
GPC3	NDST1	ENSANAP00000036441	ENSANAP00000023252	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	N-deacetylase and N-sulfotransferase 1.	0.485
HAND2	GATA6	ENSANAP00000013234	ENSANAP00000022962	Heart and neural crest derivatives expressed 2.	GATA binding protein 6.	0.534
HAND2	MYOCD	ENSANAP00000013234	ENSANAP00000039968	Heart and neural crest derivatives expressed 2.	Myocardin.	0.530
HAND2	TBX5	ENSANAP00000013234	ENSANAP00000001584	Heart and neural crest derivatives expressed 2.	T-box transcription factor 5.	0.654
HEY2	NOTCH1	ENSANAP00000011064	ENSANAP00000014724	Hes related family bHLH transcription factor with YRPW motif 2.	Notch receptor 1.	0.569