STRINGSTRING
CTSG CTSG IL1F10 IL1F10 MAPK1 MAPK1 ENSANAP00000014786 ENSANAP00000014786 ARID5A ARID5A XBP1 XBP1 PLCG2 PLCG2 HSF1 HSF1 TRIM41 TRIM41 PRKCE PRKCE LOC105725360 LOC105725360 BCL2L2-PABPN1 BCL2L2-PABPN1 UPF1 UPF1 ENSANAP00000012350 ENSANAP00000012350 CD86 CD86 EFNB2 EFNB2 MYD88 MYD88 PLAA PLAA SHPK SHPK ENSANAP00000010877 ENSANAP00000010877 TNFRSF1B TNFRSF1B ENSANAP00000010133 ENSANAP00000010133 CSF3 CSF3 TICAM1 TICAM1 SERPINE1 SERPINE1 TSPO TSPO GIT1 GIT1 AICDA AICDA CXCL10 CXCL10 NUGGC NUGGC ENSANAP00000008546 ENSANAP00000008546 DAB2IP DAB2IP ENSANAP00000008046 ENSANAP00000008046 LY96 LY96 PLSCR4 PLSCR4 ENSANAP00000000446 ENSANAP00000000446 IL1B IL1B BPIFC BPIFC LOC105725379 LOC105725379 TBXA2R TBXA2R ZC3H12A ZC3H12A RTL8C RTL8C PYCARD PYCARD LITAF LITAF STAP1 STAP1 ENSANAP00000002382 ENSANAP00000002382 THPO THPO CD36 CD36 LDOC1 LDOC1 PTPN22 PTPN22 PAF1 PAF1 GFI1 GFI1 LOC105732263 LOC105732263 GHSR GHSR MAPK10 MAPK10 CSF2 CSF2 MAPK8 MAPK8 SELENOS SELENOS SPON2 SPON2 IL24 IL24 PDCD1LG2 PDCD1LG2 IL10 IL10 ACOD1 ACOD1 BCR BCR ENSANAP00000007001 ENSANAP00000007001 ENSANAP00000006458 ENSANAP00000006458 TNIP3 TNIP3 LYN LYN IL6 IL6 ASS1 ASS1 IRGM IRGM ABL1 ABL1 HAVCR2 HAVCR2 CXCL9 CXCL9 WNT5A WNT5A KLRK1 KLRK1 NR1H4 NR1H4 ENSANAP00000025583 ENSANAP00000025583 RIPK2 RIPK2 CDC73 CDC73 NFKBIA NFKBIA IRAK1 IRAK1 CMPK2 CMPK2 NLRP3 NLRP3 MTDH MTDH ANKRD1 ANKRD1 CDK4 CDK4 ICOSLG ICOSLG CD180 CD180 PDCD4 PDCD4 IL18 IL18 IRAK2 IRAK2 GATA1 GATA1 ENSANAP00000028641 ENSANAP00000028641 ADAMTS13 ADAMTS13 KMO KMO NFKBIB NFKBIB CDK19 CDK19 BCL10 BCL10 LY86 LY86 TNF TNF CLEC17A CLEC17A CCDC142 CCDC142 IRF3 IRF3 LOC105719329 LOC105719329 PRPF8 PRPF8 TNIP2 TNIP2 SLC7A5 SLC7A5 ARG1 ARG1 NFKB1 NFKB1 ABCA1 ABCA1 SRC SRC NLRP7 NLRP7 CXCL8 CXCL8 ADAM9 ADAM9 CD6 CD6 FCAR FCAR ZFP36 ZFP36 GFER GFER CACTIN CACTIN CXCL6 CXCL6 LOC105728839 LOC105728839 CD14 CD14 LOC105713363 LOC105713363 SCARB1 SCARB1 CD80 CD80 VIM VIM PPBP PPBP IL36G IL36G PDE4B PDE4B PPARD PPARD RELA RELA TGFB1 TGFB1 ENSANAP00000036751 ENSANAP00000036751 NFKBIL1 NFKBIL1 NOS3 NOS3 MALT1 MALT1 IRF8 IRF8 AKAP8 AKAP8 SIRPA SIRPA CHMP5 CHMP5 BPI BPI TNIP1 TNIP1 CXCL13 CXCL13 LBP LBP CD68 CD68 MEF2C MEF2C MAPK3 MAPK3 NR1H3 NR1H3 CTR9 CTR9 MAPK14 MAPK14 TNFSF4 TNFSF4 PLSCR3 PLSCR3 RARA RARA CXCL11 CXCL11 TNFAIP3 TNFAIP3 AXL AXL MAP2K3 MAP2K3 HMGCS2 HMGCS2 IL36B IL36B CD274 CD274 ENSANAP00000021346 ENSANAP00000021346 TRAF6 TRAF6 MRC1 MRC1 FN1 FN1 AKT1 AKT1 IL36A IL36A CXCL1 CXCL1 EPHB2 EPHB2 IL37 IL37 JAK2 JAK2 SBNO2 SBNO2 TLR4 TLR4 CCL20 CCL20 CEBPB CEBPB IL36RN IL36RN NR1D1 NR1D1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
IL1F10Interleukin-1. (152 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
ENSANAP00000014786Uncharacterized protein. (142 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
XBP1BZIP domain-containing protein. (379 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
HSF1Heat shock transcription factor 1. (529 aa)
TRIM41Tripartite motif containing 41. (632 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC105725360C-X-C motif chemokine. (107 aa)
BCL2L2-PABPN1Uncharacterized protein. (346 aa)
UPF1UPF1 RNA helicase and ATPase. (1092 aa)
ENSANAP00000012350Uncharacterized protein. (408 aa)
CD86CD86 molecule. (331 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PLAAPhospholipase A2 activating protein. (795 aa)
SHPKFGGY_N domain-containing protein. (477 aa)
ENSANAP00000010877Defensin_propep domain-containing protein. (91 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
ENSANAP00000010133Uncharacterized protein. (104 aa)
CSF3Colony stimulating factor 3. (207 aa)
TICAM1Toll like receptor adaptor molecule 1. (538 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (366 aa)
TSPOUncharacterized protein. (169 aa)
GIT1GIT ArfGAP 1. (770 aa)
AICDAActivation induced cytidine deaminase. (198 aa)
CXCL10C-X-C motif chemokine. (97 aa)
NUGGCNuclear GTPase, germinal center associated. (796 aa)
ENSANAP00000008546Defensin_propep domain-containing protein. (91 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
ENSANAP00000008046Protein kinase domain-containing protein. (266 aa)
LY96Lymphocyte antigen 96. (160 aa)
PLSCR4Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (329 aa)
ENSANAP00000000446Uncharacterized protein. (158 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
BPIFCBPI fold containing family C. (507 aa)
LOC105725379C-X-C motif chemokine. (102 aa)
TBXA2RThromboxane A2 receptor. (357 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
RTL8CRetrotransposon Gag like 8C. (113 aa)
PYCARDPYD and CARD domain containing. (196 aa)
LITAFLipopolysaccharide induced TNF factor. (228 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
ENSANAP00000002382Uncharacterized protein. (226 aa)
THPOThrombopoietin. (307 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
LDOC1LDOC1 regulator of NFKB signaling. (145 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (809 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (555 aa)
GFI1Growth factor independent 1 transcriptional repressor. (422 aa)
LOC105732263DUF4939 domain-containing protein. (113 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
MAPK10Mitogen-activated protein kinase. (533 aa)
CSF2Colony stimulating factor 2. (144 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
SELENOSSelenoprotein S. (219 aa)
SPON2Spondin 2. (332 aa)
IL24Interleukin 24. (205 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (263 aa)
IL10Interleukin 10. (178 aa)
ACOD1Aconitate decarboxylase 1. (487 aa)
BCRBCR activator of RhoGEF and GTPase. (1161 aa)
ENSANAP00000007001Uncharacterized protein. (168 aa)
ENSANAP00000006458Uncharacterized protein. (307 aa)
TNIP3TNFAIP3 interacting protein 3. (371 aa)
LYNLYN proto-oncogene, Src family tyrosine kinase. (498 aa)
IL6Interleukin 6. (213 aa)
ASS1Uncharacterized protein. (412 aa)
IRGMImmunity related GTPase M. (188 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (277 aa)
CXCL9C-X-C motif chemokine. (126 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KLRK1Killer cell lectin like receptor K1. (217 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
ENSANAP00000025583Uncharacterized protein. (192 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
CDC73Cell division cycle 73. (557 aa)
NFKBIANFKB inhibitor alpha. (310 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (711 aa)
CMPK2Cytidine/uridine monophosphate kinase 2. (448 aa)
NLRP3NLR family pyrin domain containing 3. (1020 aa)
MTDHMetadherin. (612 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
ICOSLGUncharacterized protein. (489 aa)
CD180CD180 molecule. (661 aa)
PDCD4Programmed cell death 4. (469 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (605 aa)
GATA1GATA binding protein 1. (413 aa)
ENSANAP00000028641Uncharacterized protein. (177 aa)
ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 13. (1313 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
CDK19Cyclin dependent kinase 19; Belongs to the protein kinase superfamily. (430 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
LY86Lymphocyte antigen 86. (162 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
CLEC17AC-type lectin domain containing 17A. (352 aa)
CCDC142Coiled-coil domain containing 142. (745 aa)
IRF3Interferon regulatory factor 3. (427 aa)
LOC105719329Uncharacterized protein; Belongs to the peptidase C14A family. (404 aa)
PRPF8Pre-mRNA processing factor 8. (2335 aa)
TNIP2TNFAIP3 interacting protein 2. (424 aa)
SLC7A5Solute carrier family 7 member 5. (509 aa)
ARG1Arginase. (322 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ABCA1ATP binding cassette subfamily A member 1. (2220 aa)
SRCTyrosine-protein kinase. (542 aa)
NLRP7NLR family pyrin domain containing 7. (980 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ADAM9ADAM metallopeptidase domain 9. (820 aa)
CD6CD6 molecule. (664 aa)
FCARFc fragment of IgA receptor. (286 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
GFERSulfhydryl oxidase. (206 aa)
CACTINCactin, spliceosome C complex subunit. (791 aa)
CXCL6C-X-C motif chemokine. (114 aa)
LOC105728839Uncharacterized protein. (819 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
LOC105713363Cyclin-dependent kinase 4. (302 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (551 aa)
CD80CD80 molecule. (289 aa)
VIMVimentin; Belongs to the intermediate filament family. (467 aa)
PPBPC-X-C motif chemokine. (128 aa)
IL36GInterleukin-1. (169 aa)
PDE4BPhosphodiesterase. (736 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
RELARELA proto-oncogene, NF-kB subunit. (540 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
ENSANAP00000036751Uncharacterized protein. (101 aa)
NFKBIL1NFKB inhibitor like 1. (381 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
MALT1MALT1 paracaspase. (819 aa)
IRF8Interferon regulatory factor 8. (426 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (679 aa)
SIRPAUncharacterized protein. (473 aa)
CHMP5Uncharacterized protein. (219 aa)
BPIBactericidal permeability increasing protein. (488 aa)
TNIP1TNFAIP3 interacting protein 1. (637 aa)
CXCL13C-X-C motif chemokine. (104 aa)
LBPLipopolysaccharide binding protein. (481 aa)
CD68CD68 molecule. (345 aa)
MEF2CMyocyte enhancer factor 2C. (490 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (452 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (308 aa)
RARARetinoic acid receptor alpha. (466 aa)
CXCL11C-X-C motif chemokine. (96 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
AXLAXL receptor tyrosine kinase. (869 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (392 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (511 aa)
IL36BInterleukin 36 beta. (148 aa)
CD274CD274 molecule. (290 aa)
ENSANAP00000021346CARD domain-containing protein. (110 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
MRC1Mannose receptor C-type 1. (1321 aa)
FN1Fibronectin 1. (2478 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
IL36AInterleukin-1. (179 aa)
CXCL1C-X-C motif chemokine. (107 aa)
EPHB2EPH receptor B2. (1114 aa)
IL37Interleukin-1. (204 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
SBNO2Strawberry notch homolog 2. (1346 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
CCL20C-C motif chemokine. (96 aa)
CEBPBCCAAT/enhancer-binding protein. (321 aa)
IL36RNInterleukin-1. (155 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (615 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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