STRINGSTRING
ENSANAP00000030478 ENSANAP00000030478 KDR KDR KAT7 KAT7 TERT TERT FGF8 FGF8 WNT10B WNT10B FERMT2 FERMT2 OVOL1 OVOL1 TBX3 TBX3 WNT5A WNT5A NFIB NFIB IRF6 IRF6 ENSANAP00000008152 ENSANAP00000008152 CITED1 CITED1 WNT11 WNT11 IRS2 IRS2 SOX9 SOX9 ACE ACE PRRX1 PRRX1 ENSANAP00000011886 ENSANAP00000011886 ENSANAP00000035211 ENSANAP00000035211 TIAL1 TIAL1 RUNX2 RUNX2 OSR2 OSR2 CTNNB1 CTNNB1 HNRNPU HNRNPU PDCD2 PDCD2 PIM1 PIM1 NOTCH1 NOTCH1 ID4 ID4 WNT1 WNT1 KDM1A KDM1A TGFBR2 TGFBR2 KDF1 KDF1 LOC105721688 LOC105721688 FGF4 FGF4 YAP1 YAP1 PTCH1 PTCH1 LTBP3 LTBP3 FBLN1 FBLN1 SOX17 SOX17 FERMT1 FERMT1 EPCAM EPCAM EIF2AK2 EIF2AK2 HMGA2 HMGA2 TP63 TP63 RARG RARG TGFB1 TGFB1 HMX2 HMX2 RARB RARB VEGFC VEGFC SOX18 SOX18 NF1 NF1 ZFP36L1 ZFP36L1 KITLG KITLG NF2 NF2 ELL3 ELL3 SHOX2 SHOX2 DGCR8 DGCR8 SFN SFN FGF9 FGF9 THPO THPO ATXN1L ATXN1L N4BP2L2 N4BP2L2 SOX11 SOX11 CCNE1 CCNE1 NR2E1 NR2E1 PTPRC PTPRC SNAI2 SNAI2 HOXA3 HOXA3 SIRT6 SIRT6 ENSANAP00000039808 ENSANAP00000039808 CD109 CD109 AGO3 AGO3 FGF10 FGF10 CDKN2C CDKN2C GLI3 GLI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSANAP00000030478B30.2/SPRY domain-containing protein. (605 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (613 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1095 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
FERMT2Fermitin family member 2. (706 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
TBX3T-box transcription factor 3. (743 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
IRF6Interferon regulatory factor 6. (462 aa)
ENSANAP00000008152Uncharacterized protein. (216 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (230 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
IRS2Insulin receptor substrate 2. (1369 aa)
SOX9SRY-box transcription factor 9. (505 aa)
ACEAngiotensin-converting enzyme. (1160 aa)
PRRX1Paired related homeobox 1. (245 aa)
ENSANAP00000011886Uncharacterized protein. (350 aa)
ENSANAP00000035211Uncharacterized protein. (289 aa)
TIAL1TIA1 cytotoxic granule associated RNA binding protein like 1. (392 aa)
RUNX2RUNX family transcription factor 2. (587 aa)
OSR2Odd-skipped related transciption factor 2. (415 aa)
CTNNB1Catenin beta 1. (781 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
PDCD2Programmed cell death 2. (341 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
NOTCH1Notch receptor 1. (2527 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
LOC105721688Cyclin_C domain-containing protein; Belongs to the cyclin family. (384 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
YAP1Uncharacterized protein. (508 aa)
PTCH1Patched 1. (1453 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1265 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (706 aa)
SOX17SRY-box transcription factor 17. (410 aa)
FERMT1Fermitin family member 1. (677 aa)
EPCAMEpithelial cell adhesion molecule. (332 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (518 aa)
HMGA2Uncharacterized protein. (118 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
RARGRetinoic acid receptor gamma. (456 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
HMX2H6 family homeobox 2. (273 aa)
RARBRetinoic acid receptor beta. (448 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (424 aa)
SOX18SRY-box transcription factor 18. (381 aa)
NF1Neurofibromin 1. (2772 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
NF2Neurofibromin 2. (595 aa)
ELL3Elongation factor for RNA polymerase II 3. (399 aa)
SHOX2Short stature homeobox 2. (355 aa)
DGCR8DGCR8 microprocessor complex subunit. (773 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
THPOThrombopoietin. (307 aa)
ATXN1LAtaxin 1 like. (689 aa)
N4BP2L2NEDD4 binding protein 2 like 2. (750 aa)
SOX11Transcription factor SOX. (449 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
PTPRCUncharacterized protein. (1299 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
HOXA3Homeobox A3. (443 aa)
SIRT6Sirtuin 6. (354 aa)
ENSANAP00000039808Uncharacterized protein. (156 aa)
CD109CD109 molecule. (1446 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
GLI3GLI family zinc finger 3. (1578 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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