STRINGSTRING
PPM1A PPM1A SPART SPART SMURF1 SMURF1 SPRY3 SPRY3 XDH XDH EMILIN1 EMILIN1 WNT4 WNT4 ATP2B4 ATP2B4 NEDD4 NEDD4 GPC1 GPC1 SLIT2 SLIT2 SMURF2 SMURF2 SHISA2 SHISA2 BAMBI BAMBI NF1 NF1 NBL1 NBL1 NIBAN2 NIBAN2 FUZ FUZ THBS1 THBS1 RBPMS2 RBPMS2 AGTR2 AGTR2 SULF2 SULF2 EPN2 EPN2 GREM2 GREM2 SPRY1 SPRY1 LEMD3 LEMD3 HIPK2 HIPK2 SMAD6 SMAD6 ADGRA2 ADGRA2 DKK1 DKK1 SFRP2 SFRP2 SKI SKI AGT AGT HGS HGS LEMD2 LEMD2 CHRDL1 CHRDL1 SFRP1 SFRP1 PIK3CB PIK3CB CASK CASK DAND5 DAND5 DAB2IP DAB2IP HRG HRG HHEX HHEX VWC2L VWC2L FSTL3 FSTL3 SOST SOST CXCL13 CXCL13 TNFAIP6 TNFAIP6 LOC105730229 LOC105730229 CRIM1 CRIM1 NOTCH1 NOTCH1 MMRN2 MMRN2 SEMA6A SEMA6A CHRDL2 CHRDL2 DCN-2 DCN-2 ADAMTS12 ADAMTS12 PRDM14 PRDM14 WNT1 WNT1 HJV HJV SKOR1 SKOR1 TMPRSS6 TMPRSS6 DCN DCN HTRA1 HTRA1 SOSTDC1 SOSTDC1 SULF1 SULF1 VWC2 VWC2 CREB3L1 CREB3L1 DLX1 DLX1 CHRD CHRD GDF3 GDF3 LOC105709188 LOC105709188 NOG NOG CADM4 CADM4 FBN1 FBN1 SMAD7 SMAD7 CER1 CER1 CTDSPL2 CTDSPL2 IL12A IL12A HTRA3 HTRA3 SPRY4 SPRY4 TWSG1 TWSG1 TRIM33 TRIM33 ABL1 ABL1 WNT5A WNT5A PTPN1 PTPN1 SKOR2 SKOR2 UBE2D1 UBE2D1 GATA3 GATA3 SPRY2 SPRY2 BMPER BMPER SORL1 SORL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (454 aa)
SPARTSpartin. (664 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
SPRY3Sprouty RTK signaling antagonist 3. (273 aa)
XDHXanthine dehydrogenase. (1333 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1025 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1292 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (513 aa)
SLIT2Slit guidance ligand 2. (1541 aa)
SMURF2E3 ubiquitin-protein ligase. (736 aa)
SHISA2Shisa family member 2. (295 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
NF1Neurofibromin 1. (2772 aa)
NBL1NBL1, DAN family BMP antagonist. (216 aa)
NIBAN2Niban apoptosis regulator 2. (748 aa)
FUZFuzzy planar cell polarity protein. (360 aa)
THBS1Thrombospondin 1. (1173 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (205 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
EPN2Epsin 2. (641 aa)
GREM2Gremlin. (168 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
LEMD3LEM domain containing 3. (911 aa)
HIPK2Homeodomain interacting protein kinase 2. (1203 aa)
SMAD6Mothers against decapentaplegic homolog. (494 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1337 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
SFRP2Secreted frizzled related protein 2. (296 aa)
SKISKI proto-oncogene. (726 aa)
AGTAngiotensinogen; Belongs to the serpin family. (514 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
LEMD2LEM domain containing 2. (503 aa)
CHRDL1Chordin like 1. (452 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
HRGHistidine rich glycoprotein. (519 aa)
HHEXHematopoietically expressed homeobox. (235 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
FSTL3Follistatin like 3. (263 aa)
SOSTSclerostin. (213 aa)
CXCL13C-X-C motif chemokine. (104 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
LOC105730229PPM-type phosphatase domain-containing protein. (310 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1037 aa)
NOTCH1Notch receptor 1. (2527 aa)
MMRN2Multimerin 2. (953 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
CHRDL2Chordin like 2. (430 aa)
DCN-2Decorin; May affect the rate of fibrils formation. (97 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1600 aa)
PRDM14PR/SET domain 14. (544 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
HJVUncharacterized protein. (383 aa)
SKOR1SKI family transcriptional corepressor 1. (957 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (822 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
HTRA1HtrA serine peptidase 1. (462 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
DLX1Distal-less homeobox 1. (255 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (944 aa)
GDF3Growth differentiation factor 3. (364 aa)
LOC105709188Uncharacterized protein. (421 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CADM4Cell adhesion molecule 4. (389 aa)
FBN1Fibrillin 1. (2872 aa)
SMAD7Mothers against decapentaplegic homolog. (489 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
HTRA3HtrA serine peptidase 3. (452 aa)
SPRY4Sprouty RTK signaling antagonist 4. (317 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TRIM33Tripartite motif containing 33. (1113 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
SKOR2SKI family transcriptional corepressor 2. (960 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
GATA3GATA binding protein 3. (409 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
BMPERBMP binding endothelial regulator. (685 aa)
SORL1Sortilin related receptor 1. (2213 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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