STRINGSTRING
JAK3 JAK3 IL4R IL4R IFNG IFNG IL2RG IL2RG JUNB JUNB CBFB CBFB IL23A IL23A IL12RB1 IL12RB1 LOC105707642 LOC105707642 CBLB CBLB LOXL3 LOXL3 SHB SHB TARM1 TARM1 CD86 CD86 CCL19 CCL19 NCKAP1L NCKAP1L ENSANAP00000015746 ENSANAP00000015746 PRKCZ PRKCZ LGALS9 LGALS9 TGFBR2 TGFBR2 IL2 IL2 CD3E CD3E MYB MYB TNFSF18 TNFSF18 CD28 CD28 ITCH ITCH SMAD7 SMAD7 VSIR VSIR NDFIP1 NDFIP1 SH3RF1 SH3RF1 TWSG1 TWSG1 ANXA1 ANXA1 RUNX1 RUNX1 RUNX3 RUNX3 PRKCQ PRKCQ RIPK2 RIPK2 LGALS7B LGALS7B NLRP3 NLRP3 ARG2 ARG2 RC3H2 RC3H2 GATA3 GATA3 SOCS1 SOCS1 SOCS5 SOCS5 ZC3H12A ZC3H12A BATF BATF IL18 IL18 CD83 CD83 CARD11 CARD11 ENSANAP00000030669 ENSANAP00000030669 ZBTB7B ZBTB7B SASH3 SASH3 AGER AGER IL27 IL27 CD80 CD80 IRF4 IRF4 MALT1 MALT1 FOXP3 FOXP3 IL23R IL23R NFKBID NFKBID RC3H1 RC3H1 HLX HLX NFKBIZ NFKBIZ CD81 CD81 CD160 CD160 BCL6 BCL6 TBX21 TBX21 TNFSF4 TNFSF4 RARA RARA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK3Tyrosine-protein kinase. (1119 aa)
IL4RInterleukin 4 receptor. (830 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL2RGFibronectin type-III domain-containing protein. (345 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
CBFBCore-binding factor subunit beta. (181 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (649 aa)
LOC105707642Galectin. (128 aa)
CBLBCbl proto-oncogene B. (981 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
TARM1T cell-interacting, activating receptor on myeloid cells 1. (212 aa)
CD86CD86 molecule. (331 aa)
CCL19C-C motif chemokine. (104 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
ENSANAP00000015746SH2 domain-containing protein. (503 aa)
PRKCZProtein kinase C. (594 aa)
LGALS9Galectin. (356 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
CD3ECD3e molecule. (199 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
TNFSF18TNF superfamily member 18. (199 aa)
CD28CD28 molecule. (220 aa)
ITCHE3 ubiquitin-protein ligase. (860 aa)
SMAD7Mothers against decapentaplegic homolog. (489 aa)
VSIRV-set immunoregulatory receptor. (313 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
SH3RF1SH3 domain containing ring finger 1. (889 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ANXA1Annexin. (346 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (462 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (429 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
LGALS7BGalectin. (136 aa)
NLRP3NLR family pyrin domain containing 3. (1020 aa)
ARG2Arginase. (354 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
GATA3GATA binding protein 3. (409 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
SOCS5Uncharacterized protein. (536 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CD83CD83 molecule. (201 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
ENSANAP00000030669Uncharacterized protein. (555 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
AGERAdvanced glycosylation end-product specific receptor. (419 aa)
IL27Interleukin 27. (239 aa)
CD80CD80 molecule. (289 aa)
IRF4Interferon regulatory factor 4. (451 aa)
MALT1MALT1 paracaspase. (819 aa)
FOXP3Forkhead box P3. (456 aa)
IL23RInterleukin 23 receptor. (575 aa)
NFKBIDNFKB inhibitor delta. (459 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
HLXH2.0 like homeobox. (492 aa)
NFKBIZNFKB inhibitor zeta. (661 aa)
CD81Tetraspanin. (248 aa)
CD160CD160 molecule. (234 aa)
BCL6BCL6 transcription repressor. (677 aa)
TBX21T-box transcription factor 21. (535 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
RARARetinoic acid receptor alpha. (466 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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