(50 nodes) Positive regulation of stem cell proliferation network (Aotus nancymaae)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ENSANAP00000039808	Uncharacterized protein. (156 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	N4BP2L2	NEDD4 binding protein 2 like 2. (750 aa)
	ATXN1L	Ataxin 1 like. (689 aa)
	THPO	Thrombopoietin. (307 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SHOX2	Short stature homeobox 2. (355 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (399 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1095 aa)
	KAT7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (613 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	ENSANAP00000030478	B30.2/SPRY domain-containing protein. (605 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (806 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	OSR2	Odd-skipped related transciption factor 2. (415 aa)
	RUNX2	RUNX family transcription factor 2. (587 aa)
	TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1. (392 aa)
	ENSANAP00000035211	Uncharacterized protein. (289 aa)
	EPCAM	Epithelial cell adhesion molecule. (332 aa)
	HMGA2	Uncharacterized protein. (118 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
	HMX2	H6 family homeobox 2. (273 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	FERMT2	Fermitin family member 2. (706 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1265 aa)
	YAP1	Uncharacterized protein. (508 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	LOC105721688	Cyclin_C domain-containing protein; Belongs to the cyclin family. (384 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	ID4	Inhibitor of DNA binding 4, HLH protein. (161 aa)
	PDCD2	Programmed cell death 2. (341 aa)
	ENSANAP00000011886	Uncharacterized protein. (350 aa)
	PRRX1	Paired related homeobox 1. (245 aa)
	SOX9	SRY-box transcription factor 9. (505 aa)
	IRS2	Insulin receptor substrate 2. (1369 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (230 aa)
	ENSANAP00000008152	Uncharacterized protein. (216 aa)
	HOXA3	Homeobox A3. (443 aa)
	PTPRC	Uncharacterized protein. (1299 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (421 aa)
	CCNE1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
	SOX11	Transcription factor SOX. (449 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (424 aa)
	SIRT6	Sirtuin 6. (354 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN1L	ENSANAP00000008152	ENSANAP00000002831	ENSANAP00000008152	Ataxin 1 like.	Uncharacterized protein.	0.419
ATXN1L	ENSANAP00000035211	ENSANAP00000002831	ENSANAP00000035211	Ataxin 1 like.	Uncharacterized protein.	0.419
ATXN1L	KAT7	ENSANAP00000002831	ENSANAP00000028902	Ataxin 1 like.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.419
CCNE1	TERT	ENSANAP00000004080	ENSANAP00000028617	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.513
CTNNB1	ENSANAP00000008152	ENSANAP00000032405	ENSANAP00000008152	Catenin beta 1.	Uncharacterized protein.	0.407
CTNNB1	ENSANAP00000011886	ENSANAP00000032405	ENSANAP00000011886	Catenin beta 1.	Uncharacterized protein.	0.792
CTNNB1	ENSANAP00000035211	ENSANAP00000032405	ENSANAP00000035211	Catenin beta 1.	Uncharacterized protein.	0.407
CTNNB1	ENSANAP00000039808	ENSANAP00000032405	ENSANAP00000039808	Catenin beta 1.	Uncharacterized protein.	0.792
CTNNB1	FGF8	ENSANAP00000032405	ENSANAP00000028216	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.420
CTNNB1	HMGA2	ENSANAP00000032405	ENSANAP00000035890	Catenin beta 1.	Uncharacterized protein.	0.419
CTNNB1	KAT7	ENSANAP00000032405	ENSANAP00000028902	Catenin beta 1.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.407
CTNNB1	KDM1A	ENSANAP00000032405	ENSANAP00000016984	Catenin beta 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.456
CTNNB1	KDR	ENSANAP00000032405	ENSANAP00000029792	Catenin beta 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.942
CTNNB1	PTPRC	ENSANAP00000032405	ENSANAP00000004867	Catenin beta 1.	Uncharacterized protein.	0.421
CTNNB1	RUNX2	ENSANAP00000032405	ENSANAP00000033258	Catenin beta 1.	RUNX family transcription factor 2.	0.673
CTNNB1	SOX11	ENSANAP00000032405	ENSANAP00000003271	Catenin beta 1.	Transcription factor SOX.	0.653
CTNNB1	SOX9	ENSANAP00000032405	ENSANAP00000010675	Catenin beta 1.	SRY-box transcription factor 9.	0.760
CTNNB1	TERT	ENSANAP00000032405	ENSANAP00000028617	Catenin beta 1.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.955
CTNNB1	TGFB1	ENSANAP00000032405	ENSANAP00000036725	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.493
CTNNB1	WNT1	ENSANAP00000032405	ENSANAP00000016592	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.794