34 items (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	DHCR24	24-dehydrocholesterol reductase. (516 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (920 aa)
	LOC105706732	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (345 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
	DHCR7	7-dehydrocholesterol reductase. (482 aa)
	GGPS1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
	RUSC1	RUN and SH3 domain containing 1. (905 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1143 aa)
	FDFT1	Farnesyl-diphosphate farnesyltransferase 1. (468 aa)
	HSD17B7	Hydroxysteroid 17-beta dehydrogenase 7. (330 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	ENSANAP00000017775	Uncharacterized protein. (84 aa)
	LOC105728457	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (353 aa)
	PLPP7	Phospholipid phosphatase 7 (inactive). (271 aa)
	LBR	Lamin B receptor. (593 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1179 aa)
	NSDHL	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
	PLPP6	Phospholipid phosphatase 6. (293 aa)
	EBPL	EBP like. (204 aa)
	EBP	EXPERA domain-containing protein. (230 aa)
	TM7SF2	Transmembrane 7 superfamily member 2. (418 aa)
	CYP51A1	Uncharacterized protein; Belongs to the cytochrome P450 family. (509 aa)
	ARV1	ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (433 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	ENSANAP00000032278	Nudix hydrolase domain-containing protein. (231 aa)
	ENSANAP00000030955	Uncharacterized protein. (541 aa)
	FDPS	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (419 aa)
	SQLE	SE domain-containing protein. (574 aa)
	ENSANAP00000028457	Uncharacterized protein; Belongs to the cytochrome P450 family. (171 aa)
	SC5D	Sterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	ENSANAP00000003396	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (298 aa)
	IDI1	Isopentenyl-diphosphate delta isomerase 1. (287 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT2	CYP51A1	ENSANAP00000025661	ENSANAP00000038466	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.488
ACAT2	DHCR7	ENSANAP00000025661	ENSANAP00000022454	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	7-dehydrocholesterol reductase.	0.461
ACAT2	EBP	ENSANAP00000025661	ENSANAP00000040512	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	EXPERA domain-containing protein.	0.403
ACAT2	ENSANAP00000028457	ENSANAP00000025661	ENSANAP00000028457	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.488
ACAT2	ENSANAP00000030955	ENSANAP00000025661	ENSANAP00000030955	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.479
ACAT2	ENSANAP00000032278	ENSANAP00000025661	ENSANAP00000032278	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Nudix hydrolase domain-containing protein.	0.522
ACAT2	FDFT1	ENSANAP00000025661	ENSANAP00000008909	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Farnesyl-diphosphate farnesyltransferase 1.	0.649
ACAT2	FDPS	ENSANAP00000025661	ENSANAP00000029495	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.418
ACAT2	HMGCR	ENSANAP00000025661	ENSANAP00000025256	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.594
ACAT2	HMGCS1	ENSANAP00000025661	ENSANAP00000033951	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.996
ACAT2	HSD17B7	ENSANAP00000025661	ENSANAP00000011673	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxysteroid 17-beta dehydrogenase 7.	0.402
ACAT2	IDI1	ENSANAP00000025661	ENSANAP00000003860	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Isopentenyl-diphosphate delta isomerase 1.	0.522
ACAT2	MVD	ENSANAP00000025661	ENSANAP00000035232	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.685
ACAT2	MVK	ENSANAP00000025661	ENSANAP00000024466	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.809
ACAT2	NSDHL	ENSANAP00000025661	ENSANAP00000001435	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.	0.614
ACAT2	SC5D	ENSANAP00000025661	ENSANAP00000027849	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol-C5-desaturase; Belongs to the sterol desaturase family.	0.431
ACAT2	SQLE	ENSANAP00000025661	ENSANAP00000029181	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	SE domain-containing protein.	0.479
CYP51A1	ACAT2	ENSANAP00000038466	ENSANAP00000025661	Uncharacterized protein; Belongs to the cytochrome P450 family.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.488
CYP51A1	DHCR24	ENSANAP00000038466	ENSANAP00000033589	Uncharacterized protein; Belongs to the cytochrome P450 family.	24-dehydrocholesterol reductase.	0.985
CYP51A1	DHCR7	ENSANAP00000038466	ENSANAP00000022454	Uncharacterized protein; Belongs to the cytochrome P450 family.	7-dehydrocholesterol reductase.	0.951