30 items (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (900 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (761 aa)
	S100A1	Protein S100; Belongs to the S-100 family. (147 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (540 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
	HMGB1	High mobility group box 1. (215 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	FGB	Fibrinogen beta chain. (488 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (486 aa)
	TLR6	Toll-like receptor. (766 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	NFKBIA	NFKB inhibitor alpha. (310 aa)
	FGG	Fibrinogen gamma chain. (453 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (597 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (538 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (907 aa)
	ENSANAP00000009508	Fib_alpha domain-containing protein. (287 aa)
	LOC105706650	Uncharacterized protein. (190 aa)
	TIRAP	TIR domain containing adaptor protein. (221 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (89 aa)
	ENSANAP00000003669	Uncharacterized protein. (190 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (473 aa)
	ENSANAP00000001338	Uncharacterized protein. (192 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (131 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTK	CHUK	ENSANAP00000036529	ENSANAP00000041573	Tyrosine-protein kinase.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.773
BTK	IKBKB	ENSANAP00000036529	ENSANAP00000026527	Tyrosine-protein kinase.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.880
BTK	IKBKG	ENSANAP00000036529	ENSANAP00000028833	Tyrosine-protein kinase.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.881
BTK	IRAK4	ENSANAP00000036529	ENSANAP00000005286	Tyrosine-protein kinase.	Interleukin 1 receptor associated kinase 4.	0.583
BTK	MYD88	ENSANAP00000036529	ENSANAP00000011543	Tyrosine-protein kinase.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.596
BTK	NFKB1	ENSANAP00000036529	ENSANAP00000031621	Tyrosine-protein kinase.	Nuclear factor kappa B subunit 1.	0.428
BTK	TIRAP	ENSANAP00000036529	ENSANAP00000006348	Tyrosine-protein kinase.	TIR domain containing adaptor protein.	0.556
BTK	TLR4	ENSANAP00000036529	ENSANAP00000017232	Tyrosine-protein kinase.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.400
BTK	TRAF3	ENSANAP00000036529	ENSANAP00000009518	Tyrosine-protein kinase.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.885
CD14	LY96	ENSANAP00000034161	ENSANAP00000000003	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Lymphocyte antigen 96.	0.962
CD14	S100A8	ENSANAP00000034161	ENSANAP00000004770	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Protein S100; Belongs to the S-100 family.	0.463
CD14	S100A9	ENSANAP00000034161	ENSANAP00000000002	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Protein S100; Belongs to the S-100 family.	0.446
CD14	TLR3	ENSANAP00000034161	ENSANAP00000009875	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.553
CD14	TLR4	ENSANAP00000034161	ENSANAP00000017232	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.975
CD14	TLR6	ENSANAP00000034161	ENSANAP00000028007	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor.	0.835
CD36	S100A9	ENSANAP00000002791	ENSANAP00000000002	CD36 molecule; Belongs to the CD36 family.	Protein S100; Belongs to the S-100 family.	0.603
CD36	TLR4	ENSANAP00000002791	ENSANAP00000017232	CD36 molecule; Belongs to the CD36 family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.826
CD36	TLR6	ENSANAP00000002791	ENSANAP00000028007	CD36 molecule; Belongs to the CD36 family.	Toll-like receptor.	0.783
CHUK	BTK	ENSANAP00000041573	ENSANAP00000036529	Component of inhibitor of nuclear factor kappa B kinase complex.	Tyrosine-protein kinase.	0.773
CHUK	IKBKB	ENSANAP00000041573	ENSANAP00000026527	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.995