STRINGSTRING
RPA3 RPA3 ENSANAP00000007102 ENSANAP00000007102 APEX2 APEX2 RCBTB2 RCBTB2 RPA1 RPA1 POLE2 POLE2 POLD3 POLD3 RFC2 RFC2 ENSANAP00000014372 ENSANAP00000014372 MEIOB MEIOB RCBTB1 RCBTB1 POLD4 POLD4 RFC4 RFC4 PCNA PCNA ATAD5 ATAD5 APEX1 APEX1 POLE3 POLE3 POLD2 POLD2 RFC1 RFC1 ENSANAP00000016653 ENSANAP00000016653 LIG1 LIG1 POLD1 POLD1 ENSANAP00000014871 ENSANAP00000014871 POLB POLB ENSANAP00000000126 ENSANAP00000000126 POLE4 POLE4 RFC5 RFC5 FEN1 FEN1 RFC3 RFC3 ENSANAP00000005512 ENSANAP00000005512
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A3. (134 aa)
ENSANAP00000007102DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (467 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
RFC2Replication factor C subunit 2. (352 aa)
ENSANAP00000014372DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (276 aa)
MEIOBMeiosis specific with OB-fold. (447 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
POLD4Uncharacterized protein. (107 aa)
RFC4Replication factor C subunit 4. (363 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ATAD5ATPase family AAA domain containing 5. (1835 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (176 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
RFC1Replication factor C subunit 1. (1136 aa)
ENSANAP00000016653DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (714 aa)
LIG1DNA ligase. (881 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1066 aa)
ENSANAP00000014871Uncharacterized protein. (107 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (311 aa)
ENSANAP00000000126DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (284 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (119 aa)
RFC5Replication factor C subunit 5. (340 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC3Replication factor C subunit 3. (356 aa)
ENSANAP00000005512DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (481 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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