STRINGSTRING
SLF1 SLF1 BLM BLM RAD51 RAD51 ENSANAP00000040885 ENSANAP00000040885 DNA2 DNA2 ENSANAP00000039680 ENSANAP00000039680 RHNO1 RHNO1 NBN NBN KAT5 KAT5 ENSANAP00000034595 ENSANAP00000034595 RFC4 RFC4 RCBTB1 RCBTB1 MEIOB MEIOB WRN WRN RMI2 RMI2 TDRD3 TDRD3 ABL1 ABL1 TOPBP1 TOPBP1 ERCC4 ERCC4 ERCC1 ERCC1 ATRIP ATRIP ANKRD12 ANKRD12 ENSANAP00000020274 ENSANAP00000020274 RAD17 RAD17 BARD1 BARD1 RAD9A RAD9A BRIP1 BRIP1 ATR ATR ENSANAP00000014871 ENSANAP00000014871 RFC2 RFC2 RECQL4 RECQL4 TOP3A TOP3A EXD2 EXD2 RAD52 RAD52 RAD9B RAD9B HUS1 HUS1 ATM ATM RPA1 RPA1 RCBTB2 RCBTB2 RAD1 RAD1 RBBP8 RBBP8 RPA3 RPA3 RFC3 RFC3 EXO1 EXO1 MRE11 MRE11 BRCA1 BRCA1 RFC5 RFC5 RAD50 RAD50
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLF1SMC5-SMC6 complex localization factor 1. (1039 aa)
BLMBLM RecQ like helicase. (1415 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ENSANAP00000040885Uncharacterized protein. (237 aa)
DNA2DNA replication helicase/nuclease 2. (936 aa)
ENSANAP00000039680Uncharacterized protein. (120 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (239 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (744 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
ENSANAP00000034595SAE2 domain-containing protein. (96 aa)
RFC4Replication factor C subunit 4. (363 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
MEIOBMeiosis specific with OB-fold. (447 aa)
WRNWRN RecQ like helicase. (1386 aa)
RMI2Uncharacterized protein. (136 aa)
TDRD3Tudor domain containing 3. (727 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1522 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (303 aa)
ATRIPATR interacting protein. (790 aa)
ANKRD12Ankyrin repeat domain 12. (2057 aa)
ENSANAP00000020274Uncharacterized protein. (552 aa)
RAD17RAD17 checkpoint clamp loader component. (705 aa)
BARD1BRCA1 associated RING domain 1. (769 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (412 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1252 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2642 aa)
ENSANAP00000014871Uncharacterized protein. (107 aa)
RFC2Replication factor C subunit 2. (352 aa)
RECQL4RecQ like helicase 4. (1208 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (415 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
RAD1RAD1 checkpoint DNA exonuclease. (242 aa)
RBBP8Uncharacterized protein. (898 aa)
RPA3Replication protein A3. (134 aa)
RFC3Replication factor C subunit 3. (356 aa)
EXO1Exonuclease 1. (848 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (642 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1827 aa)
RFC5Replication factor C subunit 5. (340 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.