Your Input: | |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (170 aa) |
| | BLM | BLM RecQ like helicase. (1415 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (499 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | ENSANAP00000041846 | Ubiquitin-like domain-containing protein. (144 aa) |
| | RAD51B | RAD51 paralog B. (426 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (539 aa) |
| | ENSANAP00000041739 | IBB domain-containing protein. (436 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (303 aa) |
| | ENSANAP00000040885 | Uncharacterized protein. (237 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (936 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | LOC105713293 | Uncharacterized protein. (328 aa) |
| | CLSPN | Claspin. (1353 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | ENSANAP00000039680 | Uncharacterized protein. (120 aa) |
| | SIRT6 | Sirtuin 6. (354 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (510 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (239 aa) |
| | ENSANAP00000039113 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (113 aa) |
| | UBE2N | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | POLH | DNA polymerase eta. (710 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (744 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (369 aa) |
| | ENSANAP00000037589 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (425 aa) |
| | ENSANAP00000036978 | Rad60-SLD domain-containing protein. (60 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (529 aa) |
| | ENSANAP00000036022 | Uncharacterized protein. (113 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | ENSANAP00000035706 | Ubiquitin-like domain-containing protein. (101 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | LOC105713213 | SAP domain-containing protein. (561 aa) |
| | TIMELESS | Timeless circadian regulator. (1181 aa) |
| | ENSANAP00000034595 | SAE2 domain-containing protein. (96 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1165 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | ENSANAP00000034099 | Histone H2B; Belongs to the histone H2B family. (138 aa) |
| | SUMO2 | Small ubiquitin like modifier 2. (137 aa) |
| | ENSANAP00000033472 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (248 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (316 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | MEIOB | Meiosis specific with OB-fold. (447 aa) |
| | POLK | DNA polymerase kappa. (862 aa) |
| | ENSANAP00000031551 | DUF1725 domain-containing protein. (100 aa) |
| | ENSANAP00000031125 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (156 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (584 aa) |
| | ENSANAP00000031039 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | SIRT7 | Sirtuin 7. (400 aa) |
| | SUMO1 | Small ubiquitin-related modifier. (101 aa) |
| | LOC105721511 | Uncharacterized protein; Belongs to the histone H2B family. (89 aa) |
| | WRN | WRN RecQ like helicase. (1386 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1040 aa) |
| | SUMO3 | Small ubiquitin like modifier 3. (133 aa) |
| | ENSANAP00000029549 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | ENSANAP00000029155 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (728 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (429 aa) |
| | SLC23A3 | Solute carrier family 23 member 3. (618 aa) |
| | LOC105731119 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (569 aa) |
| | LOC105726785 | Histone H4. (103 aa) |
| | ENSANAP00000027620 | annotation not available (103 aa) |
| | LOC105726424 | Histone H2B type 1-H. (126 aa) |
| | RMI2 | Uncharacterized protein. (136 aa) |
| | LOC105726406 | Histone H2B type 1-H. (126 aa) |
| | LOC105726427 | Histone H4. (103 aa) |
| | LOC105726426 | Histone H4. (103 aa) |
| | ENSANAP00000026983 | annotation not available (103 aa) |
| | LOC105709928 | Histone H4. (103 aa) |
| | LOC105713378 | Ubiquitin-like domain-containing protein. (77 aa) |
| | LOC105732229 | Ubiquitin-like domain-containing protein. (77 aa) |
| | LOC110568879 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | TDRD3 | Tudor domain containing 3. (727 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (768 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (288 aa) |
| | LOC105709634 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (337 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (466 aa) |
| | PAXIP1 | PAX interacting protein 1. (1040 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (444 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (606 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (909 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1522 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (391 aa) |
| | ENSANAP00000023957 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (173 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (303 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (718 aa) |
| | CCNA2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (432 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2057 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (947 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4076 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (398 aa) |
| | ENSANAP00000021521 | Rad60-SLD domain-containing protein. (94 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | ENSANAP00000021022 | Uncharacterized protein. (247 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (295 aa) |
| | ENSANAP00000020967 | Uncharacterized protein. (700 aa) |
| | ENSANAP00000020660 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (175 aa) |
| | ENSANAP00000020274 | Uncharacterized protein. (552 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (176 aa) |
| | LOC105720484 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (274 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (705 aa) |
| | CDK2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa) |
| | UBXN1 | UBX domain protein 1. (370 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (639 aa) |
| | LIG3 | DNA ligase. (1015 aa) |
| | LOC105726422 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RAD51C | RAD51 paralog C. (367 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (769 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (692 aa) |
| | KDM4B | Lysine demethylase 4B. (1128 aa) |
| | RFC1 | Replication factor C subunit 1. (1136 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (412 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (327 aa) |
| | ENSANAP00000016653 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (714 aa) |
| | H2BW1 | H2B histone family member W, testis specific; Belongs to the histone H2B family. (181 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1804 aa) |
| | RNF169 | Ring finger protein 169. (691 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1252 aa) |
| | ENSANAP00000015646 | Ku_C domain-containing protein. (263 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3404 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2642 aa) |
| | ENSANAP00000014912 | Small ubiquitin-related modifier. (75 aa) |
| | TMEM182 | Transmembrane protein 182. (229 aa) |
| | ENSANAP00000014871 | Uncharacterized protein. (107 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1992 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (499 aa) |
| | POLD1 | DNA polymerase delta 1, catalytic subunit. (1066 aa) |
| | ENSANAP00000014372 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (276 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (209 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2468 aa) |
| | ENSANAP00000013465 | Small ubiquitin-related modifier. (108 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (143 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | POLE2 | DNA polymerase epsilon 2, accessory subunit. (467 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | POLQ | DNA polymerase theta. (2434 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (572 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (410 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (736 aa) |
| | PPP4R2 | Uncharacterized protein. (376 aa) |
| | KDM4A | Uncharacterized protein. (1064 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (415 aa) |
| | ENSANAP00000011650 | Rad60-SLD domain-containing protein. (87 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | LOC110567027 | SAP domain-containing protein. (565 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa) |
| | ENSANAP00000010958 | Uncharacterized protein. (311 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1440 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (650 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1039 aa) |
| | ENSANAP00000010648 | Uncharacterized protein. (116 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (546 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | ENSANAP00000009900 | Uncharacterized protein. (269 aa) |
| | ENSANAP00000008481 | Uncharacterized protein. (298 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (350 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4834 aa) |
| | LOC105705264 | Uncharacterized protein. (72 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (242 aa) |
| | ENSANAP00000007251 | Uncharacterized protein. (86 aa) |
| | CHEK2 | Checkpoint kinase 2. (589 aa) |
| | ENSANAP00000007102 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (550 aa) |
| | ENSANAP00000006464 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | RBBP8 | Uncharacterized protein. (898 aa) |
| | RPA3 | Replication protein A3. (134 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (543 aa) |
| | EXO1 | Exonuclease 1. (848 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (642 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1827 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (387 aa) |
| | ENSANAP00000004291 | annotation not available (103 aa) |
| | LOC105721457 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (533 aa) |
| | LOC105732929 | SAP domain-containing protein. (557 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (362 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | LOC105719658 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC105721512 | Histone H4. (103 aa) |
| | H2BC8 | Histone H2B; Belongs to the histone H2B family. (130 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1325 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | ENSANAP00000003293 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (419 aa) |
| | LOC105706260 | Ubiquitin-like domain-containing protein. (154 aa) |
| | LOC105721506 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSANAP00000003190 | Reverse transcriptase domain-containing protein. (277 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | ENSANAP00000002528 | DUF4502 domain-containing protein. (214 aa) |
| | ENSANAP00000002499 | annotation not available (103 aa) |
| | LOC105717114 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (210 aa) |
| | ENSANAP00000002458 | annotation not available (103 aa) |
| | ENSANAP00000002361 | Importin subunit alpha; Functions in nuclear protein import. (527 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1039 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1971 aa) |
| | ENSANAP00000001331 | Uncharacterized protein. (234 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSANAP00000001222 | annotation not available (103 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC110568754 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSANAP00000000978 | annotation not available (103 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (119 aa) |
| | LOC105713881 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC105726425 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSANAP00000000126 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (284 aa) |
