STRINGSTRING
PRIM1 PRIM1 CDK2 CDK2 LOC105731879 LOC105731879 ENSANAP00000017921 ENSANAP00000017921 MCM4 MCM4 MCM6 MCM6 ORC3 ORC3 ORC4 ORC4 ORC5 ORC5 MCM5 MCM5 ENSANAP00000007102 ENSANAP00000007102 RPA3 RPA3 CDC7 CDC7 LOC105713780 LOC105713780 MCM2 MCM2 POLE4 POLE4 ORC6 ORC6 ENSANAP00000000126 ENSANAP00000000126 CDK3 CDK3 DBF4 DBF4 GMNN GMNN MCM10 MCM10 ENSANAP00000024511 ENSANAP00000024511 MCM3 MCM3 CDC45 CDC45 MCM8 MCM8 ENSANAP00000033472 ENSANAP00000033472 ORC1 ORC1 MEIOB MEIOB POLA1 POLA1 POLA2 POLA2 MCM9 MCM9 POLE2 POLE2 ENSANAP00000014372 ENSANAP00000014372 ENSANAP00000015418 ENSANAP00000015418 ENSANAP00000016322 ENSANAP00000016322 ENSANAP00000016653 ENSANAP00000016653 ORC2 ORC2 RPA4 RPA4 CDT1 CDT1 PRIM2 PRIM2 MCM7 MCM7 POLE3 POLE3 CDC6 CDC6 RPA1 RPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
LOC105731879RPA_C domain-containing protein. (256 aa)
ENSANAP00000017921RPA_C domain-containing protein. (232 aa)
MCM4DNA helicase; Belongs to the MCM family. (866 aa)
MCM6DNA helicase; Belongs to the MCM family. (797 aa)
ORC3Origin recognition complex subunit 3. (711 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
MCM5DNA helicase; Belongs to the MCM family. (795 aa)
ENSANAP00000007102DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa)
RPA3Replication protein A3. (134 aa)
CDC7Cell division cycle 7. (597 aa)
LOC105713780RPA_C domain-containing protein. (274 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (119 aa)
ORC6Origin recognition complex subunit 6. (220 aa)
ENSANAP00000000126DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (284 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (303 aa)
DBF4DBF4-type domain-containing protein. (674 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (900 aa)
ENSANAP00000024511DBF4-type domain-containing protein. (383 aa)
MCM3DNA helicase; Belongs to the MCM family. (835 aa)
CDC45Cell division cycle 45. (594 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (863 aa)
ENSANAP00000033472Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (248 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (860 aa)
MEIOBMeiosis specific with OB-fold. (447 aa)
POLA1DNA polymerase. (1475 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (467 aa)
ENSANAP00000014372DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (276 aa)
ENSANAP00000015418CDT1 domain-containing protein. (517 aa)
ENSANAP00000016322Uncharacterized protein. (206 aa)
ENSANAP00000016653DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (714 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
RPA4Replication protein A4. (233 aa)
CDT1CDT1 domain-containing protein. (547 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (507 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (176 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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