STRINGSTRING
VWA5A VWA5A H2AC20 H2AC20 H2BC15 H2BC15 ENSANAP00000000126 ENSANAP00000000126 UNG UNG LOC105726425 LOC105726425 LOC105713881 LOC105713881 MBD4 MBD4 POLE4 POLE4 H2AC6 H2AC6 ENSANAP00000000978 ENSANAP00000000978 LOC110568754 LOC110568754 H2BC3 H2BC3 H2AJ H2AJ ENSANAP00000001222 ENSANAP00000001222 H2BU1 H2BU1 H2AC7 H2AC7 ENSANAP00000002458 ENSANAP00000002458 ENSANAP00000002499 ENSANAP00000002499 VWA5B1 VWA5B1 RFC5 RFC5 LOC105721506 LOC105721506 H2BC8 H2BC8 LOC105721512 LOC105721512 FEN1 FEN1 H2BC21 H2BC21 LOC105721457 LOC105721457 ENSANAP00000004291 ENSANAP00000004291 H2BC5 H2BC5 NEIL2 NEIL2 RFC3 RFC3 ENSANAP00000005512 ENSANAP00000005512 RPA3 RPA3 TINF2 TINF2 PARP2 PARP2 ENSANAP00000007102 ENSANAP00000007102 H2AZ2 H2AZ2 APEX2 APEX2 RCBTB2 RCBTB2 H2AZ1 H2AZ1 RPA1 RPA1 VWA5B2 VWA5B2 NEIL1 NEIL1 SMUG1 SMUG1 POLE2 POLE2 RFC2 RFC2 MPG MPG ENSANAP00000014372 ENSANAP00000014372 POLD1 POLD1 ENSANAP00000014871 ENSANAP00000014871 ENSANAP00000015243 ENSANAP00000015243 POLB POLB LIG1 LIG1 H2BW1 H2BW1 ENSANAP00000016653 ENSANAP00000016653 NEIL3 NEIL3 RFC1 RFC1 TERF2IP TERF2IP LOC105726422 LOC105726422 ADPRHL2 ADPRHL2 LIG3 LIG3 XRCC1 XRCC1 POLD2 POLD2 POT1 POT1 POLE3 POLE3 APEX1 APEX1 POLD3 POLD3 LOC105709928 LOC105709928 ENSANAP00000026983 ENSANAP00000026983 LOC105726426 LOC105726426 LOC105726427 LOC105726427 LOC105726406 LOC105726406 LOC105726424 LOC105726424 ENSANAP00000027620 ENSANAP00000027620 LOC105726785 LOC105726785 LOC105731119 LOC105731119 ENSANAP00000029155 ENSANAP00000029155 PARP1 PARP1 LOC105721511 LOC105721511 NTHL1 NTHL1 ACD ACD ENSANAP00000031039 ENSANAP00000031039 PARG PARG ENSANAP00000032143 ENSANAP00000032143 MEIOB MEIOB RCBTB1 RCBTB1 POLD4 POLD4 RFC4 RFC4 TERF1 TERF1 MUTYH MUTYH REC114 REC114 TERF2 TERF2 PNKP PNKP TDG TDG PCNA PCNA OGG1 OGG1 PARP3 PARP3 ATAD5 ATAD5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VWA5AVon Willebrand factor A domain containing 5A. (786 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (170 aa)
ENSANAP00000000126DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (284 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa)
LOC105726425Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105713881Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (530 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (119 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSANAP00000000978annotation not available (103 aa)
LOC110568754Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
ENSANAP00000001222annotation not available (103 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSANAP00000002458annotation not available (103 aa)
ENSANAP00000002499annotation not available (103 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1198 aa)
RFC5Replication factor C subunit 5. (340 aa)
LOC105721506Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC8Histone H2B; Belongs to the histone H2B family. (130 aa)
LOC105721512Histone H4. (103 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105721457Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSANAP00000004291annotation not available (103 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
NEIL2Nei like DNA glycosylase 2. (332 aa)
RFC3Replication factor C subunit 3. (356 aa)
ENSANAP00000005512DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (481 aa)
RPA3Replication protein A3. (134 aa)
TINF2TERF1 interacting nuclear factor 2. (449 aa)
PARP2Poly [ADP-ribose] polymerase. (550 aa)
ENSANAP00000007102DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1243 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (270 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (467 aa)
RFC2Replication factor C subunit 2. (352 aa)
MPGN-methylpurine DNA glycosylase. (283 aa)
ENSANAP00000014372DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (276 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1066 aa)
ENSANAP00000014871Uncharacterized protein. (107 aa)
ENSANAP00000015243Histone H2A; Belongs to the histone H2A family. (105 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (311 aa)
LIG1DNA ligase. (881 aa)
H2BW1H2B histone family member W, testis specific; Belongs to the histone H2B family. (181 aa)
ENSANAP00000016653DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (714 aa)
NEIL3Nei like DNA glycosylase 3. (588 aa)
RFC1Replication factor C subunit 1. (1136 aa)
TERF2IPTERF2 interacting protein. (399 aa)
LOC105726422Histone H2B; Belongs to the histone H2B family. (126 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (364 aa)
LIG3DNA ligase. (1015 aa)
XRCC1X-ray repair cross complementing 1. (639 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POT1Protection of telomeres 1. (648 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (176 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
LOC105709928Histone H4. (103 aa)
ENSANAP00000026983annotation not available (103 aa)
LOC105726426Histone H4. (103 aa)
LOC105726427Histone H4. (103 aa)
LOC105726406Histone H2B type 1-H. (126 aa)
LOC105726424Histone H2B type 1-H. (126 aa)
ENSANAP00000027620annotation not available (103 aa)
LOC105726785Histone H4. (103 aa)
LOC105731119Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSANAP00000029155Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa)
PARP1Poly [ADP-ribose] polymerase. (1040 aa)
LOC105721511Uncharacterized protein; Belongs to the histone H2B family. (89 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (502 aa)
ENSANAP00000031039Histone H2B; Belongs to the histone H2B family. (129 aa)
PARGPoly(ADP-ribose) glycohydrolase. (837 aa)
ENSANAP00000032143Histone H2A; Belongs to the histone H2A family. (152 aa)
MEIOBMeiosis specific with OB-fold. (447 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
POLD4Uncharacterized protein. (107 aa)
RFC4Replication factor C subunit 4. (363 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (434 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (550 aa)
REC114REC114 meiotic recombination protein. (265 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (534 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
TDGThymine DNA glycosylase. (390 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
OGG18-oxoguanine DNA glycosylase. (406 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
ATAD5ATPase family AAA domain containing 5. (1835 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: low (30%) [HD]