STRINGSTRING
H2AC20 H2AC20 H2BC15 H2BC15 LOC105726425 LOC105726425 TEN1 TEN1 POLR2C POLR2C LOC105713881 LOC105713881 H2AC6 H2AC6 ENSANAP00000000978 ENSANAP00000000978 LOC110568754 LOC110568754 H2BC3 H2BC3 H2AJ H2AJ ENSANAP00000001222 ENSANAP00000001222 H2BU1 H2BU1 H2AC7 H2AC7 LOC105728434 LOC105728434 CENPI CENPI ENSANAP00000002458 ENSANAP00000002458 ENSANAP00000002499 ENSANAP00000002499 ENSANAP00000002743 ENSANAP00000002743 RFC5 RFC5 LOC105721506 LOC105721506 ENSANAP00000003293 ENSANAP00000003293 SMARCA5 SMARCA5 RTEL1 RTEL1 H2BC8 H2BC8 LOC105721512 LOC105721512 MIS18BP1 MIS18BP1 LOC105716903 LOC105716903 FEN1 FEN1 POLR2D POLR2D H2BC21 H2BC21 CENPC CENPC LOC105721457 LOC105721457 ENSANAP00000004291 ENSANAP00000004291 ENSANAP00000004318 ENSANAP00000004318 POLR2H POLR2H H2BC5 H2BC5 POLR2A POLR2A POLR2J POLR2J RFC3 RFC3 POLR2F POLR2F RPA3 RPA3 CENPA CENPA TINF2 TINF2 ENSANAP00000006932 ENSANAP00000006932 PPP6R3 PPP6R3 GAR1 GAR1 H2AZ2 H2AZ2 LOC105722322 LOC105722322 ENSANAP00000008710 ENSANAP00000008710 ENSANAP00000008925 ENSANAP00000008925 DKC1 DKC1 TRUB1 TRUB1 ANKRD66 ANKRD66 POLR2L POLR2L RCBTB2 RCBTB2 CENPX CENPX NHP2 NHP2 SMARCA1 SMARCA1 H2AZ1 H2AZ1 RPA1 RPA1 CENPW CENPW EXD2 EXD2 RECQL4 RECQL4 RFC2 RFC2 OIP5 OIP5 POLR2B POLR2B CENPP CENPP RSF1 RSF1 POLD1 POLD1 ENSANAP00000014871 ENSANAP00000014871 ENSANAP00000015243 ENSANAP00000015243 LOC105715770 LOC105715770 RBBP4 RBBP4 LIG1 LIG1 H2BW1 H2BW1 PIF1 PIF1 LOC110567669 LOC110567669 RFC1 RFC1 WRAP53 WRAP53 TERF2IP TERF2IP HJURP HJURP CTC1 CTC1 LOC105726422 LOC105726422 NOP10 NOP10 ENSANAP00000019155 ENSANAP00000019155 CDK2 CDK2 PRIM1 PRIM1 POLD2 POLD2 POT1 POT1 ITGB3BP ITGB3BP PRIM2 PRIM2 ENSANAP00000022525 ENSANAP00000022525 SHQ1 SHQ1 KNL1 KNL1 CCNA2 CCNA2 DAXX DAXX CCNA1 CCNA1 POLR2K POLR2K ENSANAP00000024880 ENSANAP00000024880 POLD3 POLD3 ENSANAP00000025287 ENSANAP00000025287 MIS18A MIS18A LOC105727589 LOC105727589 POLA2 POLA2 CENPH CENPH LOC105727318 LOC105727318 LOC105709928 LOC105709928 ENSANAP00000026983 ENSANAP00000026983 ENSANAP00000027055 ENSANAP00000027055 LOC105726426 LOC105726426 LOC105726427 LOC105726427 PPP6R2 PPP6R2 LOC110567286 LOC110567286 ENSANAP00000027418 ENSANAP00000027418 LOC105726406 LOC105726406 LOC105726424 LOC105726424 ENSANAP00000027620 ENSANAP00000027620 LOC105726785 LOC105726785 H2AW H2AW LOC105731119 LOC105731119 POLA1 POLA1 ANKRD28 ANKRD28 TERT TERT CENPM CENPM ENSANAP00000029155 ENSANAP00000029155 ATRX ATRX ENSANAP00000029549 ENSANAP00000029549 RUVBL1 RUVBL1 WRN WRN LOC105721603 LOC105721603 LOC105721511 LOC105721511 CENPT CENPT ACD ACD ENSANAP00000031039 ENSANAP00000031039 LOC105723511 LOC105723511 PPP6C PPP6C ENSANAP00000032143 ENSANAP00000032143 ENSANAP00000032176 ENSANAP00000032176 MEIOB MEIOB LOC105712089 LOC105712089 RCBTB1 RCBTB1 POLD4 POLD4 RFC4 RFC4 ENSANAP00000033472 ENSANAP00000033472 ENSANAP00000034099 ENSANAP00000034099 TERF1 TERF1 NPM1 NPM1 CENPU CENPU CENPO CENPO POLR2I POLR2I DSCC1 DSCC1 CENPQ CENPQ ANKRD44 ANKRD44 CHTF18 CHTF18 ENSANAP00000036628 ENSANAP00000036628 CHTF8 CHTF8 RUVBL2 RUVBL2 CENPL CENPL ENSANAP00000038694 ENSANAP00000038694 TERF2 TERF2 POLR2G POLR2G PCNA PCNA DNA2 DNA2 RBBP7 RBBP7 LOC105725006 LOC105725006 CENPK CENPK CDK3 CDK3 ENSANAP00000041321 ENSANAP00000041321 STN1 STN1 BLM BLM POLR2E POLR2E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (170 aa)
LOC105726425Histone H2B; Belongs to the histone H2B family. (126 aa)
TEN1Uncharacterized protein. (123 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
LOC105713881Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSANAP00000000978annotation not available (103 aa)
LOC110568754Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
ENSANAP00000001222annotation not available (103 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC105728434Histone domain-containing protein. (165 aa)
CENPICentromere protein I. (755 aa)
ENSANAP00000002458annotation not available (103 aa)
ENSANAP00000002499annotation not available (103 aa)
ENSANAP00000002743Uncharacterized protein. (232 aa)
RFC5Replication factor C subunit 5. (340 aa)
LOC105721506Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSANAP00000003293Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (419 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1325 aa)
H2BC8Histone H2B; Belongs to the histone H2B family. (130 aa)
LOC105721512Histone H4. (103 aa)
MIS18BP1MIS18 binding protein 1. (1073 aa)
LOC105716903Histone H3; Belongs to the histone H3 family. (136 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
CENPCCentromere protein C. (910 aa)
LOC105721457Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSANAP00000004291annotation not available (103 aa)
ENSANAP00000004318Histone domain-containing protein. (106 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
POLR2JRNA_pol_L_2 domain-containing protein. (153 aa)
RFC3Replication factor C subunit 3. (356 aa)
POLR2FRNA polymerase II subunit F. (145 aa)
RPA3Replication protein A3. (134 aa)
CENPACentromere protein A. (138 aa)
TINF2TERF1 interacting nuclear factor 2. (449 aa)
ENSANAP00000006932Histone H2A; Belongs to the histone H2A family. (131 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (248 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC105722322Histone H3.3. (136 aa)
ENSANAP00000008710Uncharacterized protein. (273 aa)
ENSANAP00000008925Uncharacterized protein. (111 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
TRUB1TruB pseudouridine synthase family member 1. (351 aa)
ANKRD66Ankyrin repeat domain 66. (233 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
CENPXCentromere protein X. (127 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1039 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
CENPWCentromere protein W. (102 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
RECQL4RecQ like helicase 4. (1208 aa)
RFC2Replication factor C subunit 2. (352 aa)
OIP5Opa interacting protein 5. (253 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
CENPPCentromere protein P. (288 aa)
RSF1Remodeling and spacing factor 1. (1436 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1066 aa)
ENSANAP00000014871Uncharacterized protein. (107 aa)
ENSANAP00000015243Histone H2A; Belongs to the histone H2A family. (105 aa)
LOC105715770WD_REPEATS_REGION domain-containing protein. (426 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
LIG1DNA ligase. (881 aa)
H2BW1H2B histone family member W, testis specific; Belongs to the histone H2B family. (181 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (678 aa)
LOC110567669Uncharacterized protein. (292 aa)
RFC1Replication factor C subunit 1. (1136 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
TERF2IPTERF2 interacting protein. (399 aa)
HJURPHolliday junction recognition protein. (737 aa)
CTC1CST telomere replication complex component 1. (1214 aa)
LOC105726422Histone H2B; Belongs to the histone H2B family. (126 aa)
NOP10Uncharacterized protein. (64 aa)
ENSANAP00000019155WD_REPEATS_REGION domain-containing protein. (365 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POT1Protection of telomeres 1. (648 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (190 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (507 aa)
ENSANAP00000022525Histone H2A; Belongs to the histone H2A family. (89 aa)
SHQ1CS domain-containing protein. (574 aa)
KNL1Kinetochore scaffold 1. (2118 aa)
CCNA2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (432 aa)
DAXXDeath domain associated protein. (740 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (444 aa)
POLR2KUncharacterized protein. (67 aa)
ENSANAP00000024880Uncharacterized protein. (57 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
ENSANAP00000025287Uncharacterized protein. (256 aa)
MIS18AMIS18 kinetochore protein A. (232 aa)
LOC105727589SHQ1 domain-containing protein. (500 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
CENPHCentromere protein H. (247 aa)
LOC105727318H/ACA ribonucleoprotein complex subunit 3. (64 aa)
LOC105709928Histone H4. (103 aa)
ENSANAP00000026983annotation not available (103 aa)
ENSANAP00000027055WD_REPEATS_REGION domain-containing protein. (320 aa)
LOC105726426Histone H4. (103 aa)
LOC105726427Histone H4. (103 aa)
PPP6R2Uncharacterized protein. (965 aa)
LOC110567286Uncharacterized protein. (58 aa)
ENSANAP00000027418Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
LOC105726406Histone H2B type 1-H. (126 aa)
LOC105726424Histone H2B type 1-H. (126 aa)
ENSANAP00000027620annotation not available (103 aa)
LOC105726785Histone H4. (103 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
LOC105731119Histone H2B; Belongs to the histone H2B family. (126 aa)
POLA1DNA polymerase. (1475 aa)
ANKRD28Ankyrin repeat domain 28. (1063 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1095 aa)
CENPMCentromere protein M. (180 aa)
ENSANAP00000029155Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa)
ATRXATRX chromatin remodeler. (2480 aa)
ENSANAP00000029549Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
WRNWRN RecQ like helicase. (1386 aa)
LOC105721603Uncharacterized protein. (891 aa)
LOC105721511Uncharacterized protein; Belongs to the histone H2B family. (89 aa)
CENPTCentromere protein T. (563 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (502 aa)
ENSANAP00000031039Histone H2B; Belongs to the histone H2B family. (129 aa)
LOC105723511Uncharacterized protein. (273 aa)
PPP6CSerine/threonine-protein phosphatase. (341 aa)
ENSANAP00000032143Histone H2A; Belongs to the histone H2A family. (152 aa)
ENSANAP00000032176CAF1C_H4-bd domain-containing protein. (80 aa)
MEIOBMeiosis specific with OB-fold. (447 aa)
LOC105712089WD_REPEATS_REGION domain-containing protein. (250 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
POLD4Uncharacterized protein. (107 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSANAP00000033472Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (248 aa)
ENSANAP00000034099Histone H2B; Belongs to the histone H2B family. (138 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (434 aa)
NPM1Uncharacterized protein. (263 aa)
CENPUCentromere protein U. (420 aa)
CENPOCentromere protein O. (300 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (393 aa)
CENPQUncharacterized protein. (268 aa)
ANKRD44Ankyrin repeat domain 44. (1056 aa)
CHTF18Chromosome transmission fidelity factor 18. (1159 aa)
ENSANAP00000036628Uncharacterized protein. (218 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (477 aa)
CENPLCentromere protein L. (390 aa)
ENSANAP00000038694WD_REPEATS_REGION domain-containing protein. (358 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (534 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
DNA2DNA replication helicase/nuclease 2. (936 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (468 aa)
LOC105725006Uncharacterized protein. (292 aa)
CENPKCentromere protein K. (269 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (303 aa)
ENSANAP00000041321Uncharacterized protein. (303 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
BLMBLM RecQ like helicase. (1415 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: low (16%) [HD]