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ATP6V0C ATP6V0C FGF10 FGF10 MAPK3 MAPK3 FGF2 FGF2 PTPRF PTPRF ATP6V0B ATP6V0B ENSANAP00000040170 ENSANAP00000040170 ATP6V1E1 ATP6V1E1 FGF16 FGF16 LOC105730743 LOC105730743 ATP6AP1 ATP6AP1 ENSANAP00000037255 ENSANAP00000037255 FGF7 FGF7 PIK3C3 PIK3C3 ATP6V1B1 ATP6V1B1 ATP6V0A2 ATP6V0A2 LIM2 LIM2 ENSANAP00000033388 ENSANAP00000033388 HRAS HRAS FGF17 FGF17 ATP6V1A ATP6V1A FGF3 FGF3 ATP6AP1L ATP6AP1L PIK3R1 PIK3R1 GAB2 GAB2 ATP6V1G2 ATP6V1G2 ATP6V1B2 ATP6V1B2 ENSANAP00000030041 ENSANAP00000030041 TCIRG1 TCIRG1 FGF8 FGF8 SOS1 SOS1 FGFR2 FGFR2 NRDC NRDC IDE IDE ATP6V0D2 ATP6V0D2 FGF20 FGF20 FGF23 FGF23 PTPN1 PTPN1 ATP6V1F ATP6V1F KRAS KRAS TRIB3 TRIB3 LOC105733430 LOC105733430 GRB10 GRB10 FGF1 FGF1 GAB1 GAB1 FGF5 FGF5 FRS2 FRS2 FLT3LG FLT3LG FGF4 FGF4 INS INS KL KL LOC105722888 LOC105722888 FGF18 FGF18 ATP6V1C1 ATP6V1C1 SPEM2 SPEM2 IFITM10 IFITM10 FGF19 FGF19 PTPN11 PTPN11 PIK3CA PIK3CA ATP6V0E2 ATP6V0E2 ATP6V1C2 ATP6V1C2 FGFR3 FGFR3 ATP6V1D ATP6V1D PIK3R4 PIK3R4 LOC110569300 LOC110569300 CTSD CTSD ATP6V0E1 ATP6V0E1 ATP6V0A1 ATP6V0A1 ATP6V1G1 ATP6V1G1 MAPK1 MAPK1 FLT3 FLT3 ENSANAP00000013747 ENSANAP00000013747 ATP6V0D1 ATP6V0D1 ATP6V1G3 ATP6V1G3 THEM4 THEM4 KLB KLB IRS2 IRS2 ENSANAP00000010134 ENSANAP00000010134 ATP6V0A4 ATP6V0A4 CNST CNST FGFR4 FGFR4 ENSANAP00000008182 ENSANAP00000008182 PDE3B PDE3B INSR INSR PIK3CB PIK3CB AKT2 AKT2 FGFR1 FGFR1 GRB2 GRB2 PDPK1 PDPK1 FGF22 FGF22 LOC105717178 LOC105717178 SHC1 SHC1 SPEM1 SPEM1 LOC105714732 LOC105714732 FGF9 FGF9 ATP6V1H ATP6V1H ENSANAP00000001461 ENSANAP00000001461 NRAS NRAS ENSANAP00000000736 ENSANAP00000000736 IRS1 IRS1 FGF6 FGF6 PIK3R2 PIK3R2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1912 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (252 aa)
ENSANAP00000040170V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (116 aa)
ATP6V1E1Uncharacterized protein. (223 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC105730743Uncharacterized protein. (183 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (466 aa)
ENSANAP00000037255Uncharacterized protein. (316 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (892 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (802 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (215 aa)
ENSANAP00000033388Uncharacterized protein. (505 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
ATP6AP1LUncharacterized protein. (385 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
GAB2GRB2 associated binding protein 2. (666 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (540 aa)
ENSANAP00000030041Uncharacterized protein. (58 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (828 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
NRDCNardilysin convertase. (1229 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
KRASKRAS proto-oncogene, GTPase. (211 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
LOC105733430V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (376 aa)
GRB10Uncharacterized protein. (587 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FRS2Fibroblast growth factor receptor substrate 2. (519 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (228 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
KLKlotho. (998 aa)
LOC105722888TIR domain-containing protein. (1032 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
SPEM2SPEM family member 2. (490 aa)
IFITM10Interferon induced transmembrane protein 10. (227 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ATP6V0E2Uncharacterized protein. (130 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (429 aa)
FGFR3Fibroblast growth factor receptor. (798 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1271 aa)
LOC110569300V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (242 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (412 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (837 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
FLT3Fms related tyrosine kinase 3. (918 aa)
ENSANAP00000013747Uncharacterized protein. (107 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (388 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
THEM4Thioesterase superfamily member 4. (238 aa)
KLBKlotho beta. (1045 aa)
IRS2Insulin receptor substrate 2. (1369 aa)
ENSANAP00000010134Uncharacterized protein. (199 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (805 aa)
CNSTConsortin, connexin sorting protein. (724 aa)
FGFR4Fibroblast growth factor receptor. (691 aa)
ENSANAP00000008182Uncharacterized protein. (168 aa)
PDE3BPhosphodiesterase. (1113 aa)
INSRTyrosine-protein kinase receptor. (1302 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FGFR1Fibroblast growth factor receptor 1. (962 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (572 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (168 aa)
LOC105717178V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
SHC1SHC adaptor protein 1. (577 aa)
SPEM1Spermatid maturation 1. (311 aa)
LOC105714732V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (112 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (475 aa)
ENSANAP00000001461Uncharacterized protein. (209 aa)
NRASUncharacterized protein. (189 aa)
ENSANAP00000000736Uncharacterized protein. (229 aa)
IRS1Insulin receptor substrate 1. (1245 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R2Uncharacterized protein. (640 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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