(84 nodes) RHOC GTPase cycle network (Aotus nancymaae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARHGEF25	DH domain-containing protein. (619 aa)
	C1QBP	Uncharacterized protein. (284 aa)
	ARHGAP18	Rho GTPase activating protein 18. (656 aa)
	ARHGAP1	Rho GTPase activating protein 1. (528 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1213 aa)
	STOM	Stomatin. (287 aa)
	RTKN	Rhotekin. (564 aa)
	BCAM	Basal cell adhesion molecule (Lutheran blood group). (627 aa)
	TGM3	TGc domain-containing protein. (693 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1511 aa)
	DEPDC1B	Uncharacterized protein. (529 aa)
	MCAM	Melanoma cell adhesion molecule. (647 aa)
	RACGAP1	Rac GTPase activating protein 1. (594 aa)
	ARHGEF40	Rho guanine nucleotide exchange factor 40. (1530 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1544 aa)
	LMAN1	Lectin, mannose binding 1. (518 aa)
	RTKN2	Rhotekin 2. (609 aa)
	RNFT1	Ring finger protein, transmembrane 1. (398 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1499 aa)
	STARD13	StAR related lipid transfer domain containing 13. (1113 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (272 aa)
	OLIG1	Oligodendrocyte transcription factor 1. (267 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (970 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	ARHGEF10	Rho guanine nucleotide exchange factor 10. (1349 aa)
	ERBIN	Erbb2 interacting protein. (1459 aa)
	LOC105729166	Uncharacterized protein. (734 aa)
	SLK	STE20 like kinase. (1238 aa)
	RHOC	Ras homolog family member C. (193 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1542 aa)
	MYO9B	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2143 aa)
	LBR	Lamin B receptor. (593 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1161 aa)
	JUP	Uncharacterized protein. (745 aa)
	OPHN1	Oligophrenin 1. (802 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1528 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (483 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1635 aa)
	ACBD5	Acyl-CoA binding domain containing 5. (547 aa)
	MACO1	Macoilin 1. (664 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (866 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1624 aa)
	ARHGAP32	Rho GTPase activating protein 32. (2123 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	DAAM1	Dishevelled associated activator of morphogenesis 1. (1078 aa)
	ABCD3	ATP binding cassette subfamily D member 3. (643 aa)
	TGM6	Transglutaminase 6. (706 aa)
	ENSANAP00000018701	Uncharacterized protein. (285 aa)
	STK10	Serine/threonine kinase 10. (923 aa)
	IPO11	Importin 11. (977 aa)
	AKAP13	A-kinase anchoring protein 13. (2823 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (1102 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	RNFT2	Ring finger protein, transmembrane 2. (444 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
	STX5	Syntaxin 5; Belongs to the syntaxin family. (361 aa)
	ANLN	Anillin actin binding protein. (1129 aa)
	ENSANAP00000022714	Uncharacterized protein. (116 aa)
	ABR	ABR activator of RhoGEF and GTPase. (824 aa)
	ENSANAP00000022835	Rho-GAP domain-containing protein. (357 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2062 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (755 aa)
	VAPB	VAMP associated protein B and C. (243 aa)
	FMNL2	Formin like 2. (1067 aa)
	TFRC	Transferrin receptor. (680 aa)
	MCF2L2	MCF.2 cell line derived transforming sequence-like 2. (1091 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1958 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (1278 aa)
	ARHGAP39	Rho GTPase activating protein 39. (1114 aa)
	PKN1	Protein kinase N1. (954 aa)
	DIAPH3	Diaphanous related formin 3. (936 aa)
	VANGL1	Vang-like protein. (524 aa)
	LOC105731942	Uncharacterized protein. (529 aa)
	PKN2	Protein kinase N2. (983 aa)
	CCDC187	Uncharacterized protein. (1886 aa)
	VAMP3	Vesicle associated membrane protein 3. (100 aa)
	FMNL3	Formin like 3. (1028 aa)
	PKN3	Protein kinase N3. (879 aa)
	CAVIN1	Caveolae associated protein 1. (390 aa)
	ARHGEF17	Rho guanine nucleotide exchange factor 17. (1746 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1373 aa)
	DIAPH1	Diaphanous related formin 1. (1281 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1041 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD3	ACBD5	ENSANAP00000015625	ENSANAP00000013613	ATP binding cassette subfamily D member 3.	Acyl-CoA binding domain containing 5.	0.637
ABCD3	ANLN	ENSANAP00000015625	ENSANAP00000022603	ATP binding cassette subfamily D member 3.	Anillin actin binding protein.	0.595
ABCD3	CIT	ENSANAP00000015625	ENSANAP00000023572	ATP binding cassette subfamily D member 3.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.553
ABCD3	RHOC	ENSANAP00000015625	ENSANAP00000005709	ATP binding cassette subfamily D member 3.	Ras homolog family member C.	0.496
ABCD3	STOM	ENSANAP00000015625	ENSANAP00000041144	ATP binding cassette subfamily D member 3.	Stomatin.	0.486
ABR	ARHGAP1	ENSANAP00000022788	ENSANAP00000042042	ABR activator of RhoGEF and GTPase.	Rho GTPase activating protein 1.	0.601
ABR	DAAM1	ENSANAP00000022788	ENSANAP00000015477	ABR activator of RhoGEF and GTPase.	Dishevelled associated activator of morphogenesis 1.	0.469
ABR	DAAM2	ENSANAP00000022788	ENSANAP00000031094	ABR activator of RhoGEF and GTPase.	Dishevelled associated activator of morphogenesis 2.	0.469
ABR	MYO9B	ENSANAP00000022788	ENSANAP00000006787	ABR activator of RhoGEF and GTPase.	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.664
ABR	RHOC	ENSANAP00000022788	ENSANAP00000005709	ABR activator of RhoGEF and GTPase.	Ras homolog family member C.	0.488
ABR	TJP2	ENSANAP00000022788	ENSANAP00000041392	ABR activator of RhoGEF and GTPase.	Uncharacterized protein; Belongs to the MAGUK family.	0.471
ACBD5	ABCD3	ENSANAP00000013613	ENSANAP00000015625	Acyl-CoA binding domain containing 5.	ATP binding cassette subfamily D member 3.	0.637
ACBD5	ANLN	ENSANAP00000013613	ENSANAP00000022603	Acyl-CoA binding domain containing 5.	Anillin actin binding protein.	0.539
ACBD5	CIT	ENSANAP00000013613	ENSANAP00000023572	Acyl-CoA binding domain containing 5.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.484
ACBD5	MYO9B	ENSANAP00000013613	ENSANAP00000006787	Acyl-CoA binding domain containing 5.	Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.470
ACBD5	RHOC	ENSANAP00000013613	ENSANAP00000005709	Acyl-CoA binding domain containing 5.	Ras homolog family member C.	0.468
ACBD5	VAPB	ENSANAP00000013613	ENSANAP00000024319	Acyl-CoA binding domain containing 5.	VAMP associated protein B and C.	0.759
AKAP13	ARHGEF1	ENSANAP00000020237	ENSANAP00000004038	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor 1.	0.776
AKAP13	ARHGEF11	ENSANAP00000020237	ENSANAP00000006209	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor 11.	0.910
AKAP13	ARHGEF12	ENSANAP00000020237	ENSANAP00000037260	A-kinase anchoring protein 13.	Rho guanine nucleotide exchange factor 12.	0.922