(13 nodes) TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling network (Aotus nancymaae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	LOC105722888	TIR domain-containing protein. (1032 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	ENSANAP00000006464	UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (711 aa)
	LOC105719658	Ubiquitin-like domain-containing protein. (156 aa)
	ENSANAP00000039113	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (113 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	UBE2N	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	LOC110568879	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSANAP00000006464	IRAK1	ENSANAP00000006464	ENSANAP00000026140	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.621
ENSANAP00000006464	IRAK4	ENSANAP00000006464	ENSANAP00000005286	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Interleukin 1 receptor associated kinase 4.	0.636
ENSANAP00000006464	LOC105719658	ENSANAP00000006464	ENSANAP00000003834	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.868
ENSANAP00000006464	RPS27A	ENSANAP00000006464	ENSANAP00000041829	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.868
ENSANAP00000006464	TRAF6	ENSANAP00000006464	ENSANAP00000020369	UBIQUITIN_CONJUGAT_2 domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.944
ENSANAP00000006464	UBA52	ENSANAP00000006464	ENSANAP00000039916	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.865
ENSANAP00000039113	IRAK1	ENSANAP00000039113	ENSANAP00000026140	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Interleukin 1 receptor associated kinase 1.	0.621
ENSANAP00000039113	IRAK4	ENSANAP00000039113	ENSANAP00000005286	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Interleukin 1 receptor associated kinase 4.	0.636
ENSANAP00000039113	LOC105719658	ENSANAP00000039113	ENSANAP00000003834	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.868
ENSANAP00000039113	RPS27A	ENSANAP00000039113	ENSANAP00000041829	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.868
ENSANAP00000039113	TRAF6	ENSANAP00000039113	ENSANAP00000020369	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.944
ENSANAP00000039113	UBA52	ENSANAP00000039113	ENSANAP00000039916	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.865
IRAK1	ENSANAP00000006464	ENSANAP00000026140	ENSANAP00000006464	Interleukin 1 receptor associated kinase 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.621
IRAK1	ENSANAP00000039113	ENSANAP00000026140	ENSANAP00000039113	Interleukin 1 receptor associated kinase 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.621
IRAK1	IRAK4	ENSANAP00000026140	ENSANAP00000005286	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 4.	0.995
IRAK1	LOC105719658	ENSANAP00000026140	ENSANAP00000003834	Interleukin 1 receptor associated kinase 1.	Ubiquitin-like domain-containing protein.	0.504
IRAK1	LOC105722888	ENSANAP00000026140	ENSANAP00000022254	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein.	0.604
IRAK1	LOC110568879	ENSANAP00000026140	ENSANAP00000026681	Interleukin 1 receptor associated kinase 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.621
IRAK1	MYD88	ENSANAP00000026140	ENSANAP00000011543	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.994
IRAK1	RPS27A	ENSANAP00000026140	ENSANAP00000041829	Interleukin 1 receptor associated kinase 1.	Ubiquitin-like domain-containing protein.	0.504